Top

Published in:

01-08-2017 | Original Article

Reducing the small-heart effect in pediatric gated myocardial perfusion single-photon emission computed tomography

Authors: Hiroto Yoneyama, PhD, Kenichi Nakajima, MD, Koichi Okuda, PhD, Shinro Matsuo, MD, Masahisa Onoguchi, PhD, Seigo Kinuya, MD, Lars Edenbrandt, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 4/2017

Abstract

Background

We compared two reconstruction algorisms and two cardiac functional evaluation software programs in terms of their accuracy for estimating ejection fraction (EF) of small hearts (SH).

Methods

The study group consisted of 66 pediatric patients. Data were reconstructed using a filtered back projection (FBP) method without the resolution correction (RC) and an iterative method based on an ordered subset expectation maximization (OSEM) algorithm with the RC. EF was evaluated using two software programs of quantitative gated single-photon emission computed tomography (SPECT) (QGS) and cardioREPO. We compared the EF of gated myocardial perfusion SPECT to echocardiographic measurement (Echo).

Results

Forty-eight of 66 patients had an end-systolic volume < 20 mL which was used as the criterion for being included in the SH group, and the SH effect led to an overestimation of EF. While significant differences were observed between Echo (66.9 ± 5.0%) and QGS-FBP without RC (76.9 ± 8.4%, P < .0001), QGS-OSEM with RC (76.6 ± 8.6%, P < .0001), and cardioREPO-FBP without RC (72.1 ± 10.0%, P = .0011), no significant difference was observed between Echo and cardioREPO-OSEM with RC (67.4 ± 6.1%) in SH group.

Conclusions

In pediatric gated myocardial perfusion SPECT, the SH effect can be significantly reduced when an OSEM algorithm is used with RC in combination with the specific cardioREPO algorithm.

Available only for authorised users

Taki J, Sumiya H, Higuchi T, Tsuchiya H, Takazawa K, Tomita K, et al. Prediction of myocutaneous adverse side effect due to intra-arterial chemotherapy by intra-arterial 99mTc-macroaggregated albumin administration in patients with bone and soft-tissue tumors. J Nucl Med 2002;43:1452-6.PubMed

Hesse B, Lindhardt TB, Acampa W, Anagonostopoulos C, Ballinger J, Bax JJ, et al. EANM/ESC guideline for radionuclide imaging of cardiac function. Eur J Nucl Med Mol Imaging 2008;35:851-85.CrossRefPubMed

Taki J, Higuchi T, Sumiya H, Tsuchiya H, Minato H, Tomita K, et al. Prediction of final tumor response to preoperative chemotherapy by Tc-99m MIBI imaging at the middle of chemotherapy in malignant bone and soft tissue tumors: Comparison with Tl-201 imaging. J Orthop Surg Res. 2008;26:411-8.CrossRef

Nakajima K, Okuda K, Nystrom K, Richter J, Minarik D, Wakabayashi H, et al. Improved quantification of small hearts for gated myocardial perfusion imaging. Eur J Nucl Med Mol Imaging 2013;40:1163-70.CrossRefPubMedCentralPubMed

Paul AK, Nabi HA. Gated myocardial perfusion SPECT: Basic principles, technical aspects, and clinical applications. J Nucl Med Technol. 2004;32:179-87.PubMed

Hambye AS, Vervaet A, Dobbeleir A. Variability of left ventricular ejection fraction and volumes with quantitative gated SPECT: Influence of algorithm, pixel size and reconstruction parameters in small and normal-sized hearts. Eur J Nucl Med Imaging 2004;31:1606-13.CrossRef

Khalil MM, Elgazzar A, Khalil W, Omar A, Ziada G. Assessment of left ventricular ejection fraction by four different methods using 99mTc tetrofosmin gated SPECT in patients with small hearts: Correlation with gated blood pool. Nucl Med Commun. 2005;26:885-93.CrossRefPubMed

Danesh-Sani SH, Zakavi SR, Oskoueian L, Kakhki VR. Comparison between 99mTc-sestamibi gated myocardial perfusion SPECT and echocardiography in assessment of left ventricular volumes and ejection fraction-effect of perfusion defect and small heart. Nucl Med Rev Cent East Eur 2014;17:70-4.CrossRefPubMed

Winz OH, Meyer PT, Knollmann D, Lipke CSA, Kuhl HP, Oelve C, et al. Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: MRI validation of the EXINI heart software package. Clin Physiol Funct Imaging 2009;29:89-94.CrossRefPubMed

10.

Hedeer F, Palmer J, Arheden H, Ugander M. Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging—A comparison of four different commercial automated software packages. BMC Med Imaging 2010;10:10.CrossRefPubMedCentralPubMed

11.

Kondo C, Watanabe E, Momose M, Fukushima K, Abe K, Hagiwara N, et al. In vivo validation of gated myocardial SPECT imaging for quantification of small hearts: Comparison with cardiac MRI. EJNMMI Res 2016;6:9.CrossRefPubMedCentralPubMed

12.

Tsui BMW, Zhao XD, Gregoriou GK, Lalush DS, Frey EC, Johnston RE, et al. Quantitative cardiac SPECT reconstruction with reduced image degradation due to patient anatomy. IEEE Trans Nucl Sci 1994;41:2838-48.CrossRef

13.

Ali I, Ruddy TD, Almgrahi A, Anstett FG, Wells RG. Half-time SPECT myocardial perfusion imaging with attenuation correction. J Nucl Med 2009;50:554-62.CrossRefPubMed

14.

DePuey EG, Gadiraju R, Clerk J, Thompson L, Anstett F, Shwartz SC. Ordered subset expectation maximization and wide beam reconstruction “half-time” gated myocardial perfusion SPECT functional imaging: A comparison to “full-time” filtered backprojection. J Nucl Cardiol 2008;15:547-63.CrossRefPubMed

15.

Enevoldsen LH, Menashi CA, Andersen UB, Jensen LT, Henriksen OM. Effects of acquisition time and reconstruction algorithm on image quality, quantitative parameters, and clinical interpretation of myocardial perfusion imaging. J Nucl Cardiol 2013;20:1086-92.CrossRefPubMed

16.

Venero CV, Heller GV, Bateman TM, McGhie AI, Ahlberg AW, Katten D, et al. A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction. J Nucl Cardiol 2009;16:714-25.CrossRefPubMed

17.

Teichholz LE, Kreulen T, Herman MV, Gorlin R. Problems in echocardiographic volume determinations: Echocardiographic-angiographic correlations in the presence or absence of asynergy. Am J Cardiol 1976;37:7-11.CrossRefPubMed

18.

Kihara Y, Takenaka K, Hayashi T, Akaishi M, Ito H, Ishizuka N, et al. Standard measurement of cardiac function indexes. Jpn J Med Ultrasonics 2006;33:371-81.

19.

Lomsky M, Richter J, Johansson L, El-Ali H, Astrom K, Ljungberg M, et al. A new automated method for analysis of gated-SPECT images based on a three-dimensional heart shaped model. Clin Physiol Funct Imaging 2005;25:234-40.CrossRefPubMed

20.

Miwa S, Shirai T, Taki J, Sumiya H, Nishida H, Hayashi K, et al. Use of 99mTc-MIBI scintigraphy in the evaluation of the response to chemotherapy for osteosarcoma: Comparison with 201Tl scintigraphy and angiography. Int J Clin Oncol 2011;16:373-8.CrossRefPubMed

21.

Miwa S, Taki J, Yamamoto N, Shirai T, Nishida H, Hayashi K, et al. A novel combined radiological method for evaluation of the response to chemotherapy for primary bone sarcoma. J Surg Oncol 2012;106:273-9.CrossRefPubMed

22.

Miwa S, Takeuchi A, Shirai T, Taki J, Yamamoto N, Nishida H, et al. Prognostic value of radiological response to chemotherapy in patients with osteosarcoma. PLoS One 2013;8:e70015.CrossRefPubMedCentralPubMed

23.

Nakajima K, Nishimura T. Inter-institution preference-based variability of ejection fraction and volumes using quantitative gated SPECT with 99mTc-tetrofosmin: A multicentre study involving 106 hospitals. Eur J Nucl Med Mol Imaging 2006;33:127-33.CrossRefPubMed

24.

Nichols K, De Puey EG, Krasnow N, Lefkowitz D, Rozanski A. Reliability of enhanced gated SPECT in assessing wall motion of severely hypoperfused myocardium: Echocardiographic validation. J Nucl Cardiol 1998;5:387-94.CrossRefPubMed

25.

Cwajg E, Cwajg J, He ZX, Hwang WS, Keng F, Nagueh SF, et al. Gated myocardial perfusion tomography for the assessment of left ventricular function and volumes: Comparison with echocardiography. J Nucl Med 1999;40:1857-65.PubMed

26.

Vourvouri EC, Poldermans D, Bax JJ, Sianos G, Sozzi FB, Schinkel AF, et al. Evaluation of left ventricular function and volumes in patients with ischaemic cardiomyopathy: Gated single-photon emission computed tomography versus two-dimensional echocardiography. Eur J Nucl Med 2001;28:1610-5.CrossRefPubMed

27.

Nakajima K, Kusuoka H, Nishimura S, Yamashina A, Nishimura T. Normal limits of ejection fraction and volumes determined by gated SPECT in clinically normal patients without cardiac events: A study based on the J-ACCESS database. Eur J Nucl Med Mol Imaging 2007;34:1088-96.CrossRefPubMed

28.

Nakajima K, Higuchi T, Taki J, Kawano M, Tonami N. Accuracy of ventricular volume and ejection fraction measured by gated myocardial SPECT: Comparison of 4 software programs. J Nucl Med 2001;42:1571-8.PubMed

29.

Nishimura T, Nakajima K, Kusuoka H, Yamashina A, Nishimura S. Prognostic study of risk stratification among Japanese patients with ischemic heart disease using gated myocardial perfusion SPECT: J-ACCESS study. Eur J Nucl Med Mol Imaging 2008;35:319-28.CrossRefPubMed

30.

Takahashi Y, Miyagawa M, Nishiyama Y, Ishimura H, Mochizuki T. Performance of a semiconductor SPECT system: Comparison with a conventional Anger-type SPECT instrument. Ann Nucl Med 2013;27:11-6.CrossRefPubMed

31.

Herzog BA, Buechel RR, Katz R, Brueckner M, Husmann L, Burger IA, et al. Nuclear myocardial perfusion imaging with a cadmium-zinc-telluride detector technique: Optimized protocol for scan time reduction. Eur J Nucl Med Mol Imaging 2010;51:46-51.

32.

Buechel RR, Herzog BA, Husmann L, Burger IA, Pazhenkottil AP, Treyer V, et al. Ultrafast nuclear myocardial perfusion imaging on a new gamma camera with semiconductor detector technique: First clinical validation. Eur J Nucl Med Mol Imaging 2010;37:773-8.CrossRefPubMed

33.

Yoneyama H, Tsushima H, Kobayashi M, Onoguchi M, Nakajima K, Kinuya S. Improved detection of sentinel lymph nodes in SPECT/CT images acquired using a low-to medium-energy general-purpose collimator. Clin Nucl Med 2014;39:e1-6.CrossRefPubMed

34.

Liow JS, Strother SC. The convergence of object dependent resolution in maximum likelihood based tomographic image reconstruction. Phys Med Biol 1993;38:55-70.CrossRefPubMed

35.

Liow JS, Strother SC. The convergence of object dependent resolution in maximum likelihood based tomographic image reconstruction. Phys Med Biol 1993;38:55-70.CrossRefPubMed

36.

Nuyts J, Dupont P, Van den Maegdenbergh V, Vleugels S, Suetens P, Mortelmans L. A study of the liver-heart artifact in emission tomography. J Nucl Med 1995;36:133-9.PubMed

37.

Nakajima K, Taki J, Higuchi T, Kawano M, Taniguchi M, Maruhashi K, et al. Gated SPECT quantification of small hearts: Mathematical simulation and clinical application. Eur J Nucl Med Mol Imaging 2000;27:1372-9.CrossRef

38.

Okuda K, Nakajima K, Yamada M, Wakabayashi H, Ichikawa H, Arai H, et al. Optimization of iterative reconstruction parameters with attenuation correction, scatter correction and resolution recovery in myocardial perfusion SPECT/CT. Ann Nucl Med 2014;28:60-8.CrossRefPubMed

39.

Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, et al. EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur J Nucl Med Mol Imaging 2005;32:855-97.CrossRefPubMed

40.

Nakajima K, Okuda K, Kawano M, Matsuo S, Slomka P, Germano G, et al. The importance of population-specific normal database for quantification of myocardial ischemia: Comparison between Japanese 360 and 180-degree databases and a US database. J Nucl Cardiol 2009;16:422-30.CrossRefPubMedCentralPubMed

41.

Coleman RE, Jaszczak RJ, Cobb FR. Comparison of 180 degrees and 360 degrees data collection in thallium-201 imaging using single-photon emission computerized tomography (SPECT): Concise communication. J Nucl Med 1982;23:655-60.PubMed

42.

Tamaki N, Mukai T, Ishii Y, Fujita T, Yamamoto K, Minato K, et al. Comparative study of thallium emission myocardial tomography with 180 degrees and 360 degrees data collection. J Nucl Med 1982;23:661-6.PubMed

43.

Maublant JC, Peycelon P, Kwiatkowski F, Lusson JR, Standke RH, Veyre A. Comparison between 180 degrees and 360 degrees data collection in technetium-99m MIBI SPECT of the myocardium. J Nucl Med 1989;30:295-300.PubMed

44.

Koizumi K, Masaki H, Matsuda H, Uchiyama M, Okuno M, Oguma E, et al. Japanese consensus guidelines for pediatric nuclear medicine. Ann Nucl Med 2014;28:498-503.CrossRefPubMedCentralPubMed

45.

Fahey FH, Treves ST, Adelstein SJ. Minimizing and communicating radiation risk in pediatric nuclear medicine. J Nucl Med 2011;52:1240-51.PubMed

46.

Zanzonico P. Virtual reality for dose optimization in pediatric nuclear medicine: Better than the real thing. J Nucl Med 2011;52:1845-7.CrossRefPubMed

47.

Lassmann M, Biassoni L, Monsieurs M, Franzius C, Jacobs F. The new EANM paediatric dosage card. Eur J Nucl Med Imaging 2007;34:796-8.CrossRef

48.

Jacobs F, Thierens H, Piepsz A, Bacher K, Van de Wiele C, Ham H, et al. Optimised tracer-dependent dosage cards to obtain weight-independent effective doses. Eur J Nucl Med Imaging 2005;32:581-8.CrossRef

Title: Reducing the small-heart effect in pediatric gated myocardial perfusion single-photon emission computed tomography
Authors: Hiroto Yoneyama, PhD
Kenichi Nakajima, MD
Koichi Okuda, PhD
Shinro Matsuo, MD
Masahisa Onoguchi, PhD
Seigo Kinuya, MD
Lars Edenbrandt, MD, PhD
Publication date: 01-08-2017
Publisher: Springer International Publishing
Published in: Journal of Nuclear Cardiology / Issue 4/2017
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0518-z

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Reducing the small-heart effect in pediatric gated myocardial perfusion single-photon emission computed tomography

Abstract

Background

Methods

Results

Conclusions

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 4/2017

Myocardial perfusion imaging with 99mTc-labeled radiopharmaceuticals: How fast can a stress-rest same-day imaging protocol be completed?

Imaging the heart’s brain: Simultaneous innervation/perfusion analysis in the era of new CZT cameras

The complex principle of cause and effect

Ready, shoot, aim? Summary justice for small hearts in nuclear cardiology

The high matrix acquisition technique for imaging of atherosclerotic plaque inflammation in fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography with time-of-flight: Phantom study

Nuclear cardiology in the literature: A selection of recent, original research papers

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page