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Published in: Clinical Journal of Gastroenterology 3/2020

01-06-2020 | Erectile Dysfunction | Case Report

Acute pancreatitis induced by Tadalafil: a case report

Authors: Seyed Jafar Navabi, Mina Khosravifar, Seyed Mohammad Navabi, Ruhollah Heydari

Published in: Clinical Journal of Gastroenterology | Issue 3/2020

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Abstract

Acute pancreatitis is commonly caused by gallstones or alcohol abuse. Also, this complication has rarely been associated with other etiologies like drugs in some reports. We report the case of a 43-year-old man with 10-days history of taking Tadalafil for erectile dysfunction. The patient was presented to the emergency room with manifestations of acute pancreatitis. This diagnosis was confirmed after clinical examination, laboratory tests, and radiologic evaluation. Other probable etiological factors were ruled out. A total score of seven using Naranjo Adverse Drug Reaction Probability Scale clarifies a probable diagnosis of drug-induced acute pancreatitis in this case. The reported case of acute pancreatitis was most likely induced with Tadalafil.
Literature
1.
go back to reference Sarles H. Revised classification of pancreatitis—Marseille 1984. Dig Dis Sci. 1985;30:573–4.CrossRef Sarles H. Revised classification of pancreatitis—Marseille 1984. Dig Dis Sci. 1985;30:573–4.CrossRef
2.
go back to reference Granger J, Remick D. Acute pancreatitis: models, markers, and mediators. Shock. 2005;24:45–51.CrossRef Granger J, Remick D. Acute pancreatitis: models, markers, and mediators. Shock. 2005;24:45–51.CrossRef
3.
go back to reference Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States:2012 update. Gastroenterology. 2012;143:1179–87.CrossRef Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States:2012 update. Gastroenterology. 2012;143:1179–87.CrossRef
4.
go back to reference Peery AF, Crockett SD, Barritt AS, et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015;149:1731–41.CrossRef Peery AF, Crockett SD, Barritt AS, et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015;149:1731–41.CrossRef
5.
go back to reference Das S, Mahakkanukrauh P, Ho CC. The burden of gastrointestinal, liver, and pancreatic diseases: the global scenario. Gastroenterology. 2016;150:1045–6.CrossRef Das S, Mahakkanukrauh P, Ho CC. The burden of gastrointestinal, liver, and pancreatic diseases: the global scenario. Gastroenterology. 2016;150:1045–6.CrossRef
6.
go back to reference Forsmark CE, Baillie J. AGA Institute technical review on acute pancreatitis. Gastroenterol-Orlando. 2007;132:2022–44.CrossRef Forsmark CE, Baillie J. AGA Institute technical review on acute pancreatitis. Gastroenterol-Orlando. 2007;132:2022–44.CrossRef
7.
go back to reference Yang AL, Vadhavkar S, Singh G, et al. Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med. 2008;168:649–56.CrossRef Yang AL, Vadhavkar S, Singh G, et al. Epidemiology of alcohol-related liver and pancreatic disease in the United States. Arch Intern Med. 2008;168:649–56.CrossRef
8.
go back to reference Bahú MD, Baldisseroto M, Custodio CM, et al. Hepatobiliary and pancreatic complications of ascariasis in children: a study of seven cases. J Pediatr Gastroenterol Nutr. 2001;33:271–5.CrossRef Bahú MD, Baldisseroto M, Custodio CM, et al. Hepatobiliary and pancreatic complications of ascariasis in children: a study of seven cases. J Pediatr Gastroenterol Nutr. 2001;33:271–5.CrossRef
9.
go back to reference Uomo G, Manes G, Ragozzino A, et al. Periampullary extraluminal duodenal diverticula and acute pancreatitis: an underestimated etiological association. Am J Gastroenterol. 1996;91:1186–8. Uomo G, Manes G, Ragozzino A, et al. Periampullary extraluminal duodenal diverticula and acute pancreatitis: an underestimated etiological association. Am J Gastroenterol. 1996;91:1186–8.
10.
go back to reference Pilleul F, Rochette A, Partensky C, et al. Preoperative evaluation of intraductal papillary mucinous tumors performed by pancreatic magnetic resonance imaging and correlated with surgical and histopathologic findings. J Magn Reson Imaging. 2005;21:237–44.CrossRef Pilleul F, Rochette A, Partensky C, et al. Preoperative evaluation of intraductal papillary mucinous tumors performed by pancreatic magnetic resonance imaging and correlated with surgical and histopathologic findings. J Magn Reson Imaging. 2005;21:237–44.CrossRef
11.
go back to reference Poruk KE, Griffin JF, Wolfgang CL, et al (2019) Pancreatic and periampullary cancer. In: Shackelford's surgery of the alimentary tract, Vol. 2. Content Repository Only! pp 1136–1148 Poruk KE, Griffin JF, Wolfgang CL, et al (2019) Pancreatic and periampullary cancer. In: Shackelford's surgery of the alimentary tract, Vol. 2. Content Repository Only! pp 1136–1148
12.
go back to reference Wang DB, Yu J, Fulcher AS, et al. Pancreatitis in patients with pancreas divisum: imaging features at MRI and MRCP. World J Gastroenterol. 2013;19:4907.CrossRef Wang DB, Yu J, Fulcher AS, et al. Pancreatitis in patients with pancreas divisum: imaging features at MRI and MRCP. World J Gastroenterol. 2013;19:4907.CrossRef
13.
go back to reference Nitsche CJ, Jamieson N, Lerch MM, et al. Drug induced pancreatitis. Best Pract Res Clin Gastroenterol. 2010;24:143–55.CrossRef Nitsche CJ, Jamieson N, Lerch MM, et al. Drug induced pancreatitis. Best Pract Res Clin Gastroenterol. 2010;24:143–55.CrossRef
14.
go back to reference Lancashire RJ, Cheng K, Langman MJ. Discrepancies between population-based data and adverse reaction reports in assessing drugs as causes of acute pancreatitis. Aliment Pharmacol Ther. 2003;17:887–93.CrossRef Lancashire RJ, Cheng K, Langman MJ. Discrepancies between population-based data and adverse reaction reports in assessing drugs as causes of acute pancreatitis. Aliment Pharmacol Ther. 2003;17:887–93.CrossRef
15.
go back to reference Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62:102–11.CrossRef Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62:102–11.CrossRef
16.
go back to reference Corbin J, Francis S. Pharmacology of phosphodiesterase-5 inhibitors. Int J Clin Pract. 2001;56:453–9. Corbin J, Francis S. Pharmacology of phosphodiesterase-5 inhibitors. Int J Clin Pract. 2001;56:453–9.
17.
go back to reference Porst H, Padma-Nathan H, Giuliano F, et al. Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial. Urology. 2003;62:121–5.CrossRef Porst H, Padma-Nathan H, Giuliano F, et al. Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial. Urology. 2003;62:121–5.CrossRef
18.
go back to reference Porst H. IC351 (tadalafil, Cialis): update on clinical experience. Int J Impot Res. 2002;14:S57.CrossRef Porst H. IC351 (tadalafil, Cialis): update on clinical experience. Int J Impot Res. 2002;14:S57.CrossRef
19.
go back to reference Brock GB, McMahon CG, Chen K, et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol. 2002;168:1332–6.CrossRef Brock GB, McMahon CG, Chen K, et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol. 2002;168:1332–6.CrossRef
20.
go back to reference Emmick J, Stuewe S, Mitchell M. Overview of the cardiovascular effects of tadalafil. Eur Heart J Suppl. 2002;4:H32–H47.CrossRef Emmick J, Stuewe S, Mitchell M. Overview of the cardiovascular effects of tadalafil. Eur Heart J Suppl. 2002;4:H32–H47.CrossRef
21.
go back to reference Donatucci CF, Wong DG, Giuliano F, et al. Efficacy and safety of tadalafil once daily: considerations for the practical application of a daily dosing option. Curr Med Res Opin. 2008;24:3383–92.CrossRef Donatucci CF, Wong DG, Giuliano F, et al. Efficacy and safety of tadalafil once daily: considerations for the practical application of a daily dosing option. Curr Med Res Opin. 2008;24:3383–92.CrossRef
22.
go back to reference Committee for Medicinal Products for Human Use. Cialis. London: European Medicines Agency; 2012. p. 29. Committee for Medicinal Products for Human Use. Cialis. London: European Medicines Agency; 2012. p. 29.
24.
go back to reference Lankisch P, Dröge M, Gottesleben F. Drug induced acute pancreatitis: incidence and severity. Gut. 1995;37:565–7.CrossRef Lankisch P, Dröge M, Gottesleben F. Drug induced acute pancreatitis: incidence and severity. Gut. 1995;37:565–7.CrossRef
25.
go back to reference Avraam C, Siomos K, Armenaka M, et al. Clarithromycin associated acute pancreatitis. Ann Gastroenterol. 2007;20(1):35–7. Avraam C, Siomos K, Armenaka M, et al. Clarithromycin associated acute pancreatitis. Ann Gastroenterol. 2007;20(1):35–7.
26.
go back to reference McArthur KE. Drug-induced pancreatitis. Aliment Pharmacol Ther. 1996;10:23–38.CrossRef McArthur KE. Drug-induced pancreatitis. Aliment Pharmacol Ther. 1996;10:23–38.CrossRef
27.
go back to reference Balani AR, Grendell JH. Drug-induced pancreatitis. Drug Saf. 2008;31:823–37.CrossRef Balani AR, Grendell JH. Drug-induced pancreatitis. Drug Saf. 2008;31:823–37.CrossRef
28.
go back to reference Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239–45.CrossRef Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239–45.CrossRef
Metadata
Title
Acute pancreatitis induced by Tadalafil: a case report
Authors
Seyed Jafar Navabi
Mina Khosravifar
Seyed Mohammad Navabi
Ruhollah Heydari
Publication date
01-06-2020
Publisher
Springer Singapore
Published in
Clinical Journal of Gastroenterology / Issue 3/2020
Print ISSN: 1865-7257
Electronic ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-019-01070-x

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