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01-02-2021 | Insulins | Review

The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases

Authors: Fei Song, Xiao-Xia Zhou, Yu Hu, Gang Li, Yan Wang

Published in: Advances in Therapy | Issue 2/2021

Abstract

The insulin-like growth factor (IGF) system comprises ligands of IGF-I/II, IGF receptors (IGFR), IGF binding proteins (IGFBPs), and IGFBP hydrolases. The IGF system plays multiple roles during various disease development as IGFs are widely involved in cell proliferation and differentiation through regulating DNA transcription. Meanwhile, IGFBPs, which are mainly synthesized in the liver, can bind to IGFs and perform two different functions: either inhibition of IGFs by forming inactive compounds with IGF or enhancement of the function of IGFs by strengthening the IGF–IGFR interaction. Interestingly, IGFBPs may have wider functions through IGF-independent mechanisms. Studies have shown that IGFBPs play important roles in cardiovascular disease, tumor progression, fetal growth, and neuro-nutrition. In this review, we emphasize that different IGFBP family members have common or unique functions in numerous diseases; moreover, IGFBPs may serve as biomarkers for disease diagnosis and prediction.

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Title: The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases
Authors: Fei Song
Xiao-Xia Zhou
Yu Hu
Gang Li
Yan Wang
Publication date: 01-02-2021
Publisher: Springer Healthcare
Keywords: Insulins
Insulins
Published in: Advances in Therapy / Issue 2/2021
Print ISSN: 0741-238X
Electronic ISSN: 1865-8652
DOI: https://doi.org/10.1007/s12325-020-01581-x

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The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases

Abstract

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At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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