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01-02-2018 | Short Communication

Insulin-like growth factor-6 (IGFBP-6) stimulates neutrophil oxidative burst, degranulation and chemotaxis

Authors: Massimo Conese, Susanna D’Oria, Stefano Castellani, Rosa Trotta, Pasqualina Montemurro, Arcangelo Liso

Published in: Inflammation Research | Issue 2/2018

Abstract

The aim of this study was to understand whether insulin-like growth factor-binding protein-6 (IGFBP-6) has functional effects on neutrophils, in particular when they cross epithelium during inflammation. We found that IGFBP-6 increased ROS production (cytofluorimetry), degranulation of primary and tertiary granules (ELISA) and transmigration through the epithelial monolayer. No priming by IGFBP-6 on neutrophils stimulated by either PMA or fMLP was observed. IGFBP-6 is an agonist of neutrophils’ functions, most likely when these cells have been already activated by other stimuli.

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Title: Insulin-like growth factor-6 (IGFBP-6) stimulates neutrophil oxidative burst, degranulation and chemotaxis
Authors: Massimo Conese
Susanna D’Oria
Stefano Castellani
Rosa Trotta
Pasqualina Montemurro
Arcangelo Liso
Publication date: 01-02-2018
Publisher: Springer International Publishing
Published in: Inflammation Research / Issue 2/2018
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-017-1107-6

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