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Published in: Advances in Therapy 3/2016

Open Access 01-03-2016 | Review

Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

Authors: Henrik Hellquist, Alena Skálová, Leon Barnes, Antonio Cardesa, Lester D. R. Thompson, Asterios Triantafyllou, Michelle D. Williams, Kenneth O. Devaney, Douglas R. Gnepp, Justin A. Bishop, Bruce M. Wenig, Carlos Suárez, Juan P. Rodrigo, Andrés Coca-Pelaz, Primož Strojan, Jatin P. Shah, Marc Hamoir, Patrick J. Bradley, Carl E. Silver, Pieter J. Slootweg, Vincent Vander Poorten, Afshin Teymoortash, Jesus E. Medina, K. Thomas Robbins, Karen T. Pitman, Luiz P. Kowalski, Remco de Bree, William M. Mendenhall, Jean Anderson Eloy, Robert P. Takes, Alessandra Rinaldo, Alfio Ferlito

Published in: Advances in Therapy | Issue 3/2016

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Abstract

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC–HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.
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Metadata
Title
Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review
Authors
Henrik Hellquist
Alena Skálová
Leon Barnes
Antonio Cardesa
Lester D. R. Thompson
Asterios Triantafyllou
Michelle D. Williams
Kenneth O. Devaney
Douglas R. Gnepp
Justin A. Bishop
Bruce M. Wenig
Carlos Suárez
Juan P. Rodrigo
Andrés Coca-Pelaz
Primož Strojan
Jatin P. Shah
Marc Hamoir
Patrick J. Bradley
Carl E. Silver
Pieter J. Slootweg
Vincent Vander Poorten
Afshin Teymoortash
Jesus E. Medina
K. Thomas Robbins
Karen T. Pitman
Luiz P. Kowalski
Remco de Bree
William M. Mendenhall
Jean Anderson Eloy
Robert P. Takes
Alessandra Rinaldo
Alfio Ferlito
Publication date
01-03-2016
Publisher
Springer Healthcare
Published in
Advances in Therapy / Issue 3/2016
Print ISSN: 0741-238X
Electronic ISSN: 1865-8652
DOI
https://doi.org/10.1007/s12325-016-0298-5

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