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MUSCULOSKELETAL SURGERY

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07-01-2022 | Cutaneous Squamous Cell Carcinoma | Original Article

bcl-2 and p53 as novel biomarkers for predicting malignant transformation in chronic osteomyelitis

Authors: Hans Kristian Nugraha, I Gede Eka Wiratnaya, Putu Astawa, I Wayan Juli Sumadi

Published in: MUSCULOSKELETAL SURGERY | Issue 1/2023

Abstract

Purpose

To find whether B-cell lymphoma 2 (bcl-2) and p53 proteins could be used as parameters to detect malignant transformation of chronic osteomyelitis. We also attempted to determine whether they could be used to differentiate between secondary squamous cell carcinoma (SCC) resulting from chronic osteomyelitis, and primary cutaneous squamous cell carcinoma.

Methods

Retrospective study was conducted during 5 years period, resulting in 7 patients in each group: secondary squamous cell carcinoma arising from chronic osteomyelitis, primary cutaneous squamous cell carcinoma, and chronic osteomyelitis patients. Immunohistochemistry staining with bcl-2 and p53 was performed with the pathologist blinded to the sample groups.

Results

Contingency coefficient test was performed to assess the correlation between the biomarker status (bcl-2 and p53) and the case groups. Significant moderate correlations of bcl-2 and p53 were found between groups of chronic osteomyelitis and squamous cell carcinoma arising from chronic osteomyelitis in terms of malignant transformation (p = 0.005 for bcl-2 and p = 0.031 for p53). Insignificant correlations of bcl-2 and p53 expression were found between primary cutaneous squamous cell carcinoma and secondary squamous cell carcinoma arising from chronic osteomyelitis group (p = 0.577).

Conclusions

The expression of bcl-2 and p-53 is significantly correlated with chronic osteomyelitis malignant transformation into squamous cell carcinoma.

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Title: bcl-2 and p53 as novel biomarkers for predicting malignant transformation in chronic osteomyelitis
Authors: Hans Kristian Nugraha
I Gede Eka Wiratnaya
Putu Astawa
I Wayan Juli Sumadi
Publication date: 07-01-2022
Publisher: Springer Milan
Keywords: Cutaneous Squamous Cell Carcinoma
Osteomyelitis
Cutaneous Squamous Cell Carcinoma
Biomarkers
Published in: MUSCULOSKELETAL SURGERY / Issue 1/2023
Print ISSN: 2035-5106
Electronic ISSN: 2035-5114
DOI: https://doi.org/10.1007/s12306-021-00733-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

bcl-2 and p53 as novel biomarkers for predicting malignant transformation in chronic osteomyelitis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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