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Indian Journal of Hematology and Blood Transfusion
Published in: Indian Journal of Hematology and Blood Transfusion 1/2021

01-01-2021 | Primary Myelofibrosis | Images

Loss of Normal Polyploid Spectrum as Marker of Clonality in Acute Megakaryoblastic Leukemia Evolving from Pre-Existing Primary Myelofibrosis

Authors: Nishit Gupta, Aditi Mittal, Tina Dadu, Anil Handoo

Published in: Indian Journal of Hematology and Blood Transfusion | Issue 1/2021

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Excerpt

Normal megakaryocytes are polyploid cells with DNA content ranging from tetraploid to 128 N and originate from the diploid (2 N) promegakaryoblasts following endomitosis. Acute megakaryoblastic Leukemia (AML-M7) is characterized by differentiation blockade at the promegakaryoblast stage and induction of terminal polyploidy can be a potential therapeutic approach [1]. …
Literature
1.
Mazzi S, Lordier L, Debili N, Raslova H, Vainchenker W (2018) Megakaryocyte and polyploidization. Exp Hematol 57:1–3CrossRef
2.
Feng G, Gale RP, Cui W, Cai W, Huang G, Xu Z et al (2015) A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes. Experimental Hematol Oncol 5(1):12CrossRef
Metadata
Title
Loss of Normal Polyploid Spectrum as Marker of Clonality in Acute Megakaryoblastic Leukemia Evolving from Pre-Existing Primary Myelofibrosis
Authors
Nishit Gupta
Aditi Mittal
Tina Dadu
Anil Handoo
Publication date
01-01-2021
Publisher
Springer India
Published in
Indian Journal of Hematology and Blood Transfusion / Issue 1/2021
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-020-01355-z

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