Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Indian Journal of Hematology and Blood Transfusion
Published in: Indian Journal of Hematology and Blood Transfusion 1/2016

01-06-2016 | Case Report

Hemophagocytosis by Leukemic Blasts in T Cell Acute Lymphoblastic Leukemia: An Unusual Finding

Authors: Aradhana Harrison, Dinesh Chandra, Naveen Kakkar, Sheila Das, M. Joseph John

Published in: Indian Journal of Hematology and Blood Transfusion | Special Issue 1/2016

Login to get access

Abstract

Hemophagocytosis shows engulfment of hematopoietic cells by histiocytes and is a property generally associated with cells of the histiocytic lineage. It can be familial or is seen in a wide spectrum of acquired disorders. Hemophagocytosis by leukemic blasts is an uncommon phenomenon and has been reported mainly in acute myeloid leukemia. Its association with acute lymphoblastic leukemia is rare. We present a case of hemophagocytosis by blasts in the bone marrow in a 11 year old boy with T cell-acute lymphoblastic leukemia.
Literature
1.
Rosado FG, Kim AS (2013) Hemophagocytic lymphohistiocytosis. An update on diagnosis and pathogenesis. Am J Clin Pathol 139:713–727CrossRefPubMed
2.
Imashuku S, Hibi S, Kuriyama K, Todo S (1999) Hemophagocytosis by leukemic blasts in a case of acute megakaryoblastic leukemia with t(16;21)(p11;q22). Int J Hematol 70:36–39PubMed
3.
Gupta A, Modi CJ, Gujral S (2010) Hemophagocytosis by leukemic cells in biphenotypic acute leukemia: a rare case. Indian J Pathol Microbiol 53:370–371CrossRefPubMed
4.
Imashuku S, Hibi S, Sako M et al (2000) Hemophagocytosis by leukemic blasts in 7 acute myeloid leukemia cases with t(16;21)(p11;q22): common morphologic characteristics for this type of leukemia. Cancer 88:1970–1975CrossRefPubMed
5.
Coulthard S, Chase A, Orchard K et al (1998) Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant. Br J Haematol 100:561–563CrossRefPubMed
6.
Foadi MD, Slater AM, Pegrum GD (1978) Erythrophagocytosis by acute lymphoblastic leukaemic cells. Scand J Haematol 20:85–88CrossRefPubMed
7.
Park JE, Park IJ, Lim YA, Lee WG, Cho SR (2013) Hemophagocytosis by leukemic blasts in B lymphoblastic leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1): a case report. Ann Clin Lab Sci 43:186–189PubMed
8.
Shanley JD, Cline MJ (1977) Phagocytosis of hematopoietic cells by blast cells in blast crisis of chronic myelocytic leukemia. West J Med 126:139–141PubMedPubMedCentral
9.
Kuyama J, Fushino M, Take H, Kanayama Y (1995) Myelodysplastic syndrome associated with erythrophagocytosis by blasts and myeloid cells. Int J Hematol 62:243–246CrossRefPubMed
10.
Shikami M, Miwa H, Nishii K et al (1999) Myeloid differentiation antigen and cytokine receptor expression on acute myelocytic leukemia cells with t(16;21)(p11;q22): frequent expression of CD56 and interleukin-2 receptor alpha chain. Br J Haematol 105:711–719CrossRefPubMed
11.
Irfan A, Sahin F, Kaptan K, Safal M, Beyan C (2008) A case of adult acute T-cell lymphoblastic leukemia presented with hemophagocytic syndrome. Turk J Hematol 25:155–156
12.
Trebo MM, Attarbaschi A, Mann G, Minkov M, Kornmüller R, Gadner H (2005) Histiocytosis following T-acute lymphoblastic leukemia: a BFM study. Leuk Lymphoma 46:1735–1741CrossRefPubMed
13.
Moritake H, Kamimura S, Nunoi H et al (2014) Clinical characteristics and genetic analysis of childhood acute lymphoblastic leukemia with hemophagocytic lymphohistiocytosis: a Japanese retrospective study by the Kyushu-Yamaguchi Children’s Cancer Study Group. Int J Hematol 100:70–78CrossRefPubMed
Metadata
Title
Hemophagocytosis by Leukemic Blasts in T Cell Acute Lymphoblastic Leukemia: An Unusual Finding
Authors
Aradhana Harrison
Dinesh Chandra
Naveen Kakkar
Sheila Das
M. Joseph John
Publication date
01-06-2016
Publisher
Springer India
Published in
Indian Journal of Hematology and Blood Transfusion / Issue Special Issue 1/2016
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-015-0531-4

Other articles of this Special Issue 1/2016

Indian Journal of Hematology and Blood Transfusion 1/2016 Go to the issue

Case Report

CD5 Positive B Lymphoblastic Leukemia: Report of a Case with Review of Literature

Correspondence

Lymphocytic Platelet Satellitism

Correspondence

Cholestasis in a Patient of Multiple Myeloma: A Rare Occurrence of Bortezomib Induced Liver Injury

Correspondence

Anemia and Thrombocytopenia in New H5N6 Influenza: Existed or not?

Case Report

Dysfibrinogenemia with Subgaleal Hematoma: An Unusual Presentation

Correspondence

Neutrophil Erythrocyte Rosettes: An Unusual Manifestation of Autoimmune Hemolytic Anemia
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits