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Current Fungal Infection Reports
Published in: Current Fungal Infection Reports 2/2020

01-06-2020 | Care | Advances in Diagnosis of Invasive Fungal Infections (O Morrissey, Section Editor)

Diagnosis of Invasive Aspergillosis in Intensive Care Unit Patients

Authors: Lore Vanderbeke, Eric Van Wijngaerden, Johan Maertens, Joost Wauters, Katrien Lagrou

Published in: Current Fungal Infection Reports | Issue 2/2020

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Abstract

Purpose of Review

Invasive aspergillosis is a frequent opportunistic infection in the intensive care unit. Diagnostic strategies within this setting are not well-defined.

Recent Findings

In the absence of histopathological proof, estimation of likelihood of disease is required, based on a combination of host factors with clinical, microbiological and radiologic findings. Importantly, the at-risk critically ill population has expanded beyond the classical immunosuppressed patients. Clinical features are non-specific, yet overt organ failure is associated with an increased risk and should raise the suspicion of invasive fungal disease. Validation of serological and molecular diagnostics is complicated by the lack of universal definitions in critically ill patients.

Summary

Improved awareness of novel risk groups can promote early diagnosis. Development of novel, host immune response driven biomarkers and universal definitions of invasive fungal disease in intensive care units is urgently needed.
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Metadata
Title
Diagnosis of Invasive Aspergillosis in Intensive Care Unit Patients
Authors
Lore Vanderbeke
Eric Van Wijngaerden
Johan Maertens
Joost Wauters
Katrien Lagrou
Publication date
01-06-2020
Publisher
Springer US
Published in
Current Fungal Infection Reports / Issue 2/2020
Print ISSN: 1936-3761
Electronic ISSN: 1936-377X
DOI
https://doi.org/10.1007/s12281-020-00383-6

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