Published in:
Open Access
01-12-2016 | Fungal Genomics and Pathogenesis (S Shoham, Section Editor)
Pathogenesis of Fungal Infections in Cystic Fibrosis
Authors:
Craig Williams, Ranjith Ranjendran, Gordon Ramage
Published in:
Current Fungal Infection Reports
|
Issue 4/2016
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Abstract
For a long time, the microbiology of cystic fibrosis has been focussed on Pseudomonas aeruginosa and associated Gram-negative pathogens. An increasing body of evidence has been compiled demonstrating an important role for moulds and yeasts within this complex patient group. Whether or not fungi are active participants, spectators or transient passersby remain to be elucidated. However, functionally, they do appear to play a contributory role in pathogenesis, albeit we do not know if this is a direct or indirect effect. The following review examines some of the key evidence for the role of fungi in CF pathogenesis.