Published in:
01-06-2019 | Original Article
Long-Term Weight Gain Associated With High Omentin Levels at Hospital Discharge Improves Prognosis of Patients Following Acute Heart Failure
Authors:
Rosa M. Agra-Bermejo, Rocio Gonzalez-Ferreiro, J. Nicolos Lopez-Canoa, Alfonso Varela-Roman, Ines Gomez-Otero, Sonia Eiras, José R. González-Juanatey
Published in:
Journal of Cardiovascular Translational Research
|
Issue 3/2019
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Abstract
A obesity paradox has been described following heart failure (HF). The aim of this study was to analyze the association between food intake-involved adipokines and long-term weight changes. Leptin, adiponectin, and omentin were analyzed in 92 acute HF (AHF) patients at discharge, classified on the basis of weight gains or losses > 6%. The mean follow-up was 256 ± 143 days. Leptin and adiponectin levels were similar among weight groups. However, omentin levels were higher in those patients who had gained weight (16 ± 5 ng/mL) than in those who had lost weight (12 ± 4 ng/mL) or showed no weight change (11 ± 5 ng/mL; p < 0.002). Omentin levels were the best independent predictors for patients with weight gain, who had less mortality and hospital readmission during the follow-up. The association between omentin levels and weight gain might explain part of the obesity paradox in HF.