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Journal of Cardiovascular Translational Research

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01-02-2019 | Review

New Insights into the Role of Exosomes in the Heart After Myocardial Infarction

Authors: Na Li, Luc Rochette, Yongxin Wu, Nathalie Rosenblatt-Velin

Published in: Journal of Cardiovascular Translational Research | Issue 1/2019

Abstract

Intercellular communications play a pivotal role in several cardiac pathophysiological processes. One subtype of extracellular vesicles, so-called exosomes, became known as important intercellular communication mediators in the heart. Exosomes are lipid bilayer biological nanovesicles loaded with diverse proteins, lipids, and mRNAs/microRNAs. All major cardiac cell types can modulate recipient cellular function via the release of exosomes. After myocardial infarction (MI), exosomes, especially those secreted by different cardiac stem cells, have been shown to confer cardioprotective effects, activate regenerative signals, and participate into cardiac repair. In this review, we rapidly recall the biology of exosomes at the beginning. Then we summarize the exosomes secreted by different myocardial cells and their function in cardiac intercellular communication. At last, we discuss the role of these vesicles in cardiac repair after MI.

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Title: New Insights into the Role of Exosomes in the Heart After Myocardial Infarction
Authors: Na Li
Luc Rochette
Yongxin Wu
Nathalie Rosenblatt-Velin
Publication date: 01-02-2019
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 1/2019
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-018-9831-z

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Abstract

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