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Journal of Cardiovascular Translational Research

Published in:

01-02-2019 | Review Article

The Exosome-Derived Biomarker in Atherosclerosis and Its Clinical Application

Authors: Mengmeng Lu, Shuaifang Yuan, Shicheng Li, Ling Li, Min Liu, Shaogui Wan

Published in: Journal of Cardiovascular Translational Research | Issue 1/2019

Abstract

Exosomes are now accepted as potential biomarkers in cardiovascular disease development, especially in atherosclerosis. Atherosclerosis is a leading cause of cardiovascular disease-related death and morbidity, accounting for one-fifth of all deaths globally. Therefore, the biomarkers for the management of atherosclerosis is urgently needed. Exosomes are reported to play key roles cell-to-cell communication in atherosclerosis with lipid bilayer membranous vesicles containing nucleic acids, proteins, and lipid contents, which are released from all most of multiple kinds of living cells. This review aims to discuss the potential roles of exosome-derived miRNA, protein, and DNA as biomarkers in atherosclerosis pathogenesis, diagnosis, and therapy.

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Title: The Exosome-Derived Biomarker in Atherosclerosis and Its Clinical Application
Authors: Mengmeng Lu
Shuaifang Yuan
Shicheng Li
Ling Li
Min Liu
Shaogui Wan
Publication date: 01-02-2019
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 1/2019
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-018-9796-y

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