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Journal of Cardiovascular Translational Research

Published in:

01-12-2018 | Original Article

Effect of Long-Term Exercise Training on lncRNAs Expression in the Vascular Injury of Insulin Resistance

Authors: Suixin Liu, Fan Zheng, Ying Cai, Wenliang Zhang, Yaoshan Dun

Published in: Journal of Cardiovascular Translational Research | Issue 6/2018

Abstract

LncRNA microarray analysis was applied to investigate the exercise effect on the global differential expressions of lncRNA and mRNA in aorta endothelium in insulin resistance. Twenty-four male C57BL/6 J mice were randomly divided into three groups: control group (n = 8), high-fat diet group (n = 8), and high-fat diet plus exercise training group (n = 8). An lncRNA microarray analysis was applied to investigate the global differential expressions of lncRNA and mRNA in aorta endothelium among three groups and the results were further verified by qPCR. Hypergeometric distribution analysis was applied to reveal the possible signaling. Exercise might alleviate the vascular injury of IR via FR030200-Col3A1, FR402720-Rnd1, and FR030200/FR402720-Rnd3 signalings in cytoskeletal rearrangement pathway; E2F1-FR030200/FR402720-Nnat and FR030200/ FR402720-Fam46a signalings in anti-inflammation pathway. This study identified a panel of dysregulated lncRNAs and mRNAs that might serve as potential biomarkers relevant to the vascular injury in insulin resistance induced by high-fat diet.

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Title: Effect of Long-Term Exercise Training on lncRNAs Expression in the Vascular Injury of Insulin Resistance
Authors: Suixin Liu
Fan Zheng
Ying Cai
Wenliang Zhang
Yaoshan Dun
Publication date: 01-12-2018
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 6/2018
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-018-9830-0

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