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Journal of Cardiovascular Translational Research
Published in: Journal of Cardiovascular Translational Research 2/2017

Open Access 01-04-2017 | Original Article

In Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (the TRISKELE)

Authors: Benyamin Rahmani, Spyros Tzamtzis, Rose Sheridan, Michael J Mullen, John Yap, Alexander M. Seifalian, Gaetano Burriesci

Published in: Journal of Cardiovascular Translational Research | Issue 2/2017

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Abstract

This study presents the in vitro hydrodynamic assessment of the TRISKELE, a new system suitable for transcatheter aortic valve implantation (TAVI), aiming to mitigate the procedural challenges experienced with current technologies. The TRISKELE valve comprises three polymeric leaflet and an adaptive sealing cuff, supported by a novel fully retrievable self-expanding nitinol wire frame. Valve prototypes were manufactured in three sizes of 23, 26, and 29 mm by automated dip-coating of a biostable polymer, and tested in a hydrodynamic bench setup in mock aortic roots of 21, 23, 25, and 27 mm annulus, and compared to two reference valves suitable for equivalent implantation ranges: Edwards SAPIEN XT and Medtronic CoreValve. The TRISKELE valves demonstrated a global hydrodynamic performance comparable or superior to the controls with significant reduction in paravalvular leakage. The TRISKELE valve exhibits enhanced anchoring and improved sealing. The valve is currently under preclinical investigation.
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Metadata
Title
In Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (the TRISKELE)
Authors
Benyamin Rahmani
Spyros Tzamtzis
Rose Sheridan
Michael J Mullen
John Yap
Alexander M. Seifalian
Gaetano Burriesci
Publication date
01-04-2017
Publisher
Springer US
Published in
Journal of Cardiovascular Translational Research / Issue 2/2017
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-016-9722-0

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