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Journal of Cardiovascular Translational Research

Published in:

01-04-2015

Concentrations of Highly Sensitive Cardiac Troponin-I Predict Poor Cardiovascular Outcomes and Adverse Remodeling in Chronic Heart Failure

Authors: Shweta R. Motiwala, Hanna K. Gaggin, Parul U. Gandhi, Arianna Belcher, Rory B. Weiner, Aaron L. Baggish, Jackie Szymonifka, James L. Januzzi Jr.

Published in: Journal of Cardiovascular Translational Research | Issue 3/2015

Abstract

Highly sensitive troponin (hsTn) assays may predict cardiovascular (CV) events and left ventricular (LV) remodeling in patients with heart failure (HF). In this study, 99 subjects with LV systolic dysfunction (LVSD) were followed 10 ± 3 months with serial measurement of hsTnI by a novel method. hsTnI was detectable in all subjects and was above the 99th percentile of a normal population in 56.7 %. Supramedian baseline hsTnI concentration was associated with higher-risk clinical features and shorter time-to-first event (p = 0.008). Across serial measurements, more time spent ≤10.9 pg/mL was associated with a lower CV event rate after adjustment (odds ratio (OR) = 0.81; p = 0.008); rising hsTnI also predicted progressive LV remodeling. In conclusion, hsTnI detected significant myocardial necrosis in a majority of patients with chronic HF due to LVSD and when measured serially, provided independent risk information for poor CV outcomes and deleterious LV remodeling.

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Title: Concentrations of Highly Sensitive Cardiac Troponin-I Predict Poor Cardiovascular Outcomes and Adverse Remodeling in Chronic Heart Failure
Authors: Shweta R. Motiwala
Hanna K. Gaggin
Parul U. Gandhi
Arianna Belcher
Rory B. Weiner
Aaron L. Baggish
Jackie Szymonifka
James L. Januzzi Jr.
Publication date: 01-04-2015
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 3/2015
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-015-9618-4

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