Published in:
01-08-2012
The Clinical Relevance of the Clopidogrel–Proton Pump Inhibitor Interaction
Authors:
Atif Mohammad, Emmanouil S. Brilakis, Rick A. Weideman, Bertis B. Little, Subhash Banerjee
Published in:
Journal of Cardiovascular Translational Research
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Issue 4/2012
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Abstract
Proton pump inhibitors are often prescribed concomitantly with clopidogrel and aspirin to patients post-percutaneous coronary interventions and/or an acute coronary syndrome to mitigate the risk of potential gastrointestinal bleeding, associated primarily with clopidogrel use. Over the last several years, there have been data both supporting and refuting a clopidogrel–proton pump inhibitor interaction. This review critically considers the current evidence and provides practical recommendations to healthcare providers.