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International Journal of Hematology
Published in: International Journal of Hematology 3/2017

01-09-2017 | Progress in Hematology

Recent insights into the molecular basis of Fanconi anemia: genes, modifiers, and drivers

Authors: Ronald S. Cheung, Toshiyasu Taniguchi

Published in: International Journal of Hematology | Issue 3/2017

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Abstract

Fanconi anemia (FA), the most common form of inherited bone marrow failure, predisposes to leukemia and solid tumors. FA is caused by the genetic disruption of a cellular pathway that repairs DNA interstrand crosslinks. The impaired function of this pathway, and the genetic instability that results, is considered the main pathogenic mechanism behind this disease. The identification of breast cancer susceptibility genes (for example, BRCA1/FANCS and BRCA2/FANCD1) as being major players in the FA pathway has led to a surge in molecular studies, resulting in the concept of the FA-BRCA pathway. In this review, we discuss recent advances in the molecular pathogenesis of FA from three viewpoints: (a) new FA genes, (b) modifier pathways that influence the cellular and clinical phenotypes of FA and (c) non-canonical functions of FA genes that may drive disease progression independently of deficient DNA repair. Potential therapeutic approaches for FA that are relevant to each will also be proposed.
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Metadata
Title
Recent insights into the molecular basis of Fanconi anemia: genes, modifiers, and drivers
Authors
Ronald S. Cheung
Toshiyasu Taniguchi
Publication date
01-09-2017
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 3/2017
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-017-2283-4

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