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Current Cardiovascular Risk Reports

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Open Access 01-04-2017 | Hypertension (S. Padmanabhan, Section Editor)

Novel Immune Mechanisms in Hypertension and Cardiovascular Risk

Authors: Ryszard Nosalski, Eilidh McGinnigle, Mateusz Siedlinski, Tomasz J. Guzik

Published in: Current Cardiovascular Risk Reports | Issue 4/2017

Abstract

Purpose of Review

Hypertension is a common disorder with substantial impact on public health due to highly elevated cardiovascular risk. The mechanisms still remain unclear and treatments are not sufficient to reduce risk in majority of patients. Inflammatory mechanisms may provide an important mechanism linking hypertension and cardiovascular risk. We aim to review newly identified immune and inflammatory mechanisms of hypertension with focus on their potential therapeutic impact.

Recent Findings

In addition to the established role of the vasculature, kidneys and central nervous system in pathogenesis of hypertension, low-grade inflammation contributes to this disorder as indicated by experimental models and GWAS studies pointing to SH2B3 immune gene as top key driver of hypertension. Immune responses in hypertension are greatly driven by neoantigens generated by oxidative stress and modulated by chemokines such as RANTES, IP-10 and microRNAs including miR-21 and miR-155 with other molecules under investigation. Cells of both innate and adoptive immune system infiltrate vasculature and kidneys, affecting their function by releasing pro-inflammatory mediators and reactive oxygen species.

Summary

Immune and inflammatory mechanisms of hypertension provide a link between high blood pressure and increased cardiovascular risk, and reduction of blood pressure without attention to these underlying mechanisms is not sufficient to reduce risk.

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Title: Novel Immune Mechanisms in Hypertension and Cardiovascular Risk
Authors: Ryszard Nosalski
Eilidh McGinnigle
Mateusz Siedlinski
Tomasz J. Guzik
Publication date: 01-04-2017
Publisher: Springer US
Published in: Current Cardiovascular Risk Reports / Issue 4/2017
Print ISSN: 1932-9520
Electronic ISSN: 1932-9563
DOI: https://doi.org/10.1007/s12170-017-0537-6

ACC 2024 Congress Coverage

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Novel Immune Mechanisms in Hypertension and Cardiovascular Risk

Abstract

Purpose of Review

Recent Findings

Summary

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

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Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page