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01-08-2020 | Osteoarthrosis | Original Article

Assessing the effects of body weight on subchondral bone formation with quantitative ¹⁸F-sodium fluoride PET

Authors: Tiffany H. Khaw, William Y. Raynor, Austin J. Borja, Abdullah Al-Zaghal, Venkata S. Jonnakuti, Nina Cheng, Sina Houshmand, Thomas J. Werner, Abass Alavi

Published in: Annals of Nuclear Medicine | Issue 8/2020

Abstract

Objectives

The aim of this study was to quantify subchondral bone remodeling in the elbows, hands, knees, and feet using volumetric and metabolic parameters derived from ¹⁸F-sodium fluoride positron emission tomography (NaF-PET) and to assess the convergent validity of these parameters as an index of joint degeneration and preclinical osteoarthritis.

Methods

A retrospective analysis was conducted in 34 subjects (32 males, 2 females) with metastatic bone disease who underwent full-body NaF-PET/CT scans. An adaptive contrast-oriented thresholding algorithm was applied to segment NaF-avid regions in the bilateral elbows, hands, knees, and feet of each subject, and metabolically active volume (MAV), maximum standardized uptake value (SUVmax), mean metabolic volumetric product (MVPmean), and partial volume-corrected MVPmean (cMVPmean) of the segmented regions were calculated. Global parameters for MAV, SUVmax, MVPmean, and cMVPmean were defined as the sum of the corresponding values in all the joints of a subject. Inter-rater reliability was determined with Lin’s concordance correlation, and associations of global values with subject body weight and age were assessed with Pearson correlation and Spearman correlation analyses.

Results

Inter-rater reliability was observed to be the highest in SUVmax (ρc = 0.99), followed by MVPmean (ρc = 0.96), cMVPmean (ρc = 0.93), and MAV (ρc = 0.93). MAV, MVPmean, and cMVPmean were observed to significantly increase with weight (all p < 0.0001) determined by Pearson correlation. In addition, Spearman rank-order analysis demonstrated a significant correlation between SUVmax and weight in addition to MAV, MVPmean, and cMVPmean and weight (all p < 0.01). No significant association between age and any PET parameter was observed.

Conclusions

These preliminary data demonstrate the feasibility and reliability of assessing bone turnover at the joints using quantitative NaF-PET. Our findings corroborate the fact that biomechanical factors including mechanical loading and weight-bearing are contributors to osteoarthritis disease progression.

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Title: Assessing the effects of body weight on subchondral bone formation with quantitative 18F-sodium fluoride PET
Authors: Tiffany H. Khaw
William Y. Raynor
Austin J. Borja
Abdullah Al-Zaghal
Venkata S. Jonnakuti
Nina Cheng
Sina Houshmand
Thomas J. Werner
Abass Alavi
Publication date: 01-08-2020
Publisher: Springer Singapore
Keywords: Osteoarthrosis
Computed Tomography
Computed Tomography
Osteoarthrosis
Positron Emission Tomography
Published in: Annals of Nuclear Medicine / Issue 8/2020
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-020-01482-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Assessing the effects of body weight on subchondral bone formation with quantitative ¹⁸F-sodium fluoride PET

Abstract

Objectives

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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