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01-07-2017 | Original Article

IQ-SPECT for thallium-201 myocardial perfusion imaging: effect of normal databases on quantification

Authors: Takahiro Konishi, Kenichi Nakajima, Koichi Okuda, Hiroto Yoneyama, Shinro Matsuo, Takayuki Shibutani, Masahisa Onoguchi, Seigo Kinuya

Published in: Annals of Nuclear Medicine | Issue 6/2017

Abstract

Objective

Although IQ-single-photon emission computed tomography (SPECT) provides rapid acquisition and attenuation-corrected images, the unique technology may create characteristic distribution different from the conventional imaging. This study aimed to compare the diagnostic performance of IQ-SPECT using Japanese normal databases (NDBs) with that of the conventional SPECT for thallium-201 (²⁰¹Tl) myocardial perfusion imaging (MPI).

Methods

A total of 36 patients underwent 1-day ²⁰¹Tl adenosine stress–rest MPI. Images were acquired with IQ-SPECT at approximately one-quarter of the standard time of conventional SPECT. Projection data acquired with the IQ-SPECT system were reconstructed via an ordered subset conjugate gradient minimizer method with or without scatter and attenuation correction (SCAC). Projection data obtained using the conventional SPECT were reconstructed via a filtered back projection method without SCAC. The summed stress score (SSS) was calculated using NDBs created by the Japanese Society of Nuclear Medicine working group, and scores were compared between IQ-SPECT and conventional SPECT using the acquisition condition-matched NDBs. The diagnostic performance of the methods for the detection of coronary artery disease was also compared.

Results

SSSs were 6.6 ± 8.2 for the conventional SPECT, 6.6 ± 9.4 for IQ-SPECT without SCAC, and 6.5 ± 9.7 for IQ-SPECT with SCAC (p = n.s. for each comparison). The SSS showed a strong positive correlation between conventional SPECT and IQ-SPECT (r = 0.921 and p < 0.0001), and the correlation between IQ-SPECT with and without SCAC was also good (r = 0.907 and p < 0.0001). Regarding diagnostic performance, the sensitivity, specificity, and accuracy were 80.8, 78.9, and 79.4%, respectively, for the conventional SPECT; 80.8, 80.3, and 82.0%, respectively, for IQ-SPECT without SCAC; and 88.5, 86.8, and 87.3%, respectively, for IQ-SPECT with SCAC, respectively. The area under the curve obtained via receiver operating characteristic analysis were 0.77, 0.80, and 0.86 for conventional SPECT, IQ-SPECT without SCAC, and IQ-SPECT with SCAC, respectively (p = n.s. for each comparison).

Conclusions

When appropriate NDBs were used, the diagnostic performance of ²⁰¹Tl IQ-SPECT was comparable with that of the conventional system regardless of different characteristics of myocardial accumulation in the conventional system.

Hachamovitch R, Hayes SW, Friedman JD, Cohen I, Berman DS. Comparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography. Circulation. 2003;107:2900–7.CrossRefPubMed

Berman DS, Hachamovitch R, Kiat H, Cohen I, Cabico JA, Wang FP, et al. Incremental value of prognostic testing in patients with known or suspected ischemic heart disease: a basis for optimal utilization of exercise technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol. 1995;26:639–47.CrossRefPubMed

Caobelli F, Kaiser SR, Thackeray JT, Bengel FM, Chieregato M, Soffientini A, et al. IQ SPECT allows a significant reduction in administered dose and acquisition time for myocardial perfusion imaging: evidence from a phantom study. J Nucl Med. 2014;55:2064–70.CrossRefPubMed

Caobelli F, Thackeray JT, Soffientini A, Bengel FM, Pizzocaro C, Guerra UP. Feasibility of one-eighth time gated myocardial perfusion SPECT functional imaging using IQ-SPECT. Eur J Nucl Med Mol Imaging. 2015;42:1920–8.CrossRefPubMed

Matsuo S, Nakajima K, Onoguchi M, Wakabayash H, Okuda K, Kinuya S. Nuclear myocardial perfusion imaging using thallium-201 with a novel multifocal collimator SPECT/CT: IQ-SPECT versus conventional protocols in normal subjects. Ann Nucl Med. 2015;29:452–9.CrossRefPubMed

Group JCSJW. Guidelines for clinical use of cardiac nuclear medicine (JCS 2010). Circ J. 2012;76:761–7.CrossRef

Pagnanelli RA, Basso DA. Myocardial perfusion imaging with 201Tl. J Nucl Med Technol. 2010;38:1–3.CrossRefPubMed

Nakajima K, Matsumoto N, Kasai T, Matsuo S, Kiso K, Okuda K. Normal values and standardization of parameters in nuclear cardiology: Japanese Society of Nuclear Medicine working group database. Ann Nucl Med. 2016;30:188–99.CrossRefPubMedPubMedCentral

Okuda K, Nakajima K, Matsuo S, Kondo C, Sarai M, Horiguchi Y, et al. Creation and characterization of normal myocardial perfusion imaging databases using the IQSPECT system. J Nucl Cardiol. 2016 [Epub ahead of print].

10.

Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statementfor healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105:539–42.CrossRefPubMed

11.

Lyon MC, Foster C, Ding X, Dorbala S, Spence D, Bhattacharya M, et al. Dose reduction in half-time myocardial perfusion SPECT-CT with multifocal collimation. J Nucl Cardiol. 2016;23:657–67.CrossRefPubMed

12.

Matsutomo N, Nagaki A, Sasaki M. Performance of myocardial perfusion imaging using multi-focus fan beam collimator with resolution recovery reconstruction in a comparison with conventional SPECT. Asia Oceania J Nucl Med Biol. 2014;2:111–9.

13.

Caobelli F, Ren Kaiser S, Thackeray JT, Bengel FM, Chieregato M, Soffientini A, et al. The importance of a correct positioning of the heart using IQ-SPECT system with multifocal collimators in myocardial perfusion imaging: a phantom study. J Nucl Cardiol. 2015;22:57–65.CrossRefPubMed

14.

Yoda S, Nakanishi K, Tano A, Hori Y, Suzuki Y, Matsumoto N, et al. Validation of automated quantification of nuclear cardiology in Japanese patients using total perfusion deficits: comparison with visual assessment. J Cardiol. 2014;63:350–7.CrossRefPubMed

15.

Xu Y, Fish M, Gerlach J, Lemley M, Berman DS, Germano G, et al. Combined quantitative analysis of attenuation corrected and non-corrected myocardial perfusion SPECT: method development and clinical validation. J Nucl Cardiol. 2010;17:591–9.CrossRefPubMedPubMedCentral

16.

Yoda S, Nakanishi K, Tano A, Hori Y, Suzuki Y, Matsumoto N, et al. Diagnostic value of automated quantification of nuclear cardiology in Japanese patients with single vessel coronary artery disease: comparison between Japanese and American normal databases. J Cardiol. 2013;62:224–9.CrossRefPubMed

17.

Nakajima K, Okuda K, Kawano M, Matsuo S, Slomka P, Germano G, et al. The importance of population-specific normal database for quantification of myocardial ischemia: comparison between Japanese 360 and 180-degree databases and a US database. J Nucl Cardiol. 2009;16:422–30.CrossRefPubMedPubMedCentral

18.

Havel M, Kolacek M, Kaminek M, Dedek V, Kraft O, Sirucek P. Myocardial perfusion imaging parameters: IQSPECT and conventional SPECT system comparison. Hell J Nucl Med. 2014;17:200–3.PubMed

19.

Gremillet E, Agostini D. How to use cardiac IQ*SPECT routinely? An overview of tips and tricks from practical experience to the literature. Eur J Nucl Med Mol Imaging. 2016;43:707–10.CrossRefPubMed

20.

Horiguchi Y, Ueda T, Shiomori T, Kanna M, Matsushita H, Kawaminami T, et al. Validation of a short-scan-time imaging protocol for thallium-201 myocardial SPECT with a multifocal collimator. Ann Nucl Med. 2014;28:707–15.CrossRefPubMed

21.

Ogino Y, Horiguchi Y, Ueda T, Shiomori T, Kanna M, Kawaminami T, et al. A myocardial perfusion imaging system using a multifocal collimator for detecting coronary artery disease: validation with invasive coronary angiography. Ann Nucl Med. 2015;29:366–70.CrossRefPubMed

Title: IQ-SPECT for thallium-201 myocardial perfusion imaging: effect of normal databases on quantification
Authors: Takahiro Konishi
Kenichi Nakajima
Koichi Okuda
Hiroto Yoneyama
Shinro Matsuo
Takayuki Shibutani
Masahisa Onoguchi
Seigo Kinuya
Publication date: 01-07-2017
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 6/2017
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-017-1170-7

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Springer Medicine

IQ-SPECT for thallium-201 myocardial perfusion imaging: effect of normal databases on quantification

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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