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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 4/2015

01-05-2015 | Original Article

A myocardial perfusion imaging system using a multifocal collimator for detecting coronary artery disease: validation with invasive coronary angiography

Authors: Yutaka Ogino, Yoriko Horiguchi, Tomohiro Ueda, Tomofumi Shiomori, Masahiko Kanna, Tomoko Kawaminami, Naoki Iinuma, Yuta Sudo, Yukiko Morita

Published in: Annals of Nuclear Medicine | Issue 4/2015

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Abstract

Objective

Myocardial perfusion imaging (MPI) systems using a multifocal collimator can reduce scan time substantially compared with conventional MPI systems. In this study, we evaluated the diagnostic accuracy of multifocal collimator SPECT/CT in coronary artery disease (CAD) detection by comparing it with coronary artery angiography (CAG).

Methods

We retrospectively analyzed 50 consecutive patients who had undergone CAG and stress 201Tl MPI multifocal collimator SPECT/CT within a 3-month period. A summed difference score (SDS) was calculated for each vascular territory from the MPI images. On CAG, a stenotic coronary artery was defined as one with luminal narrowing of ≥75 % with quantitative coronary angiography software.

Results

We analyzed the diagnostic accuracy of coronary artery stenosis detection using the definition that a coronary artery territory was ischemic when the SDS per vessel was ≥2. We generated receiver operating characteristic (ROC) curves to evaluate the usefulness of SDS per vascular territory to find coronary artery stenoses. The area under the ROC curve was 0.86 and cut-off value was 2. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy to detect stenoses were 85, 83, 66, 94 and 84 %, respectively.

Conclusions

We confirmed the high accuracy of imaging with multifocal collimator SPECT/CT for detection of angiographically significant CAD.
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Metadata
Title
A myocardial perfusion imaging system using a multifocal collimator for detecting coronary artery disease: validation with invasive coronary angiography
Authors
Yutaka Ogino
Yoriko Horiguchi
Tomohiro Ueda
Tomofumi Shiomori
Masahiko Kanna
Tomoko Kawaminami
Naoki Iinuma
Yuta Sudo
Yukiko Morita
Publication date
01-05-2015
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 4/2015
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-015-0955-9

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