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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 10/2012

01-12-2012 | Original article

A comparative study of breast-specific gamma imaging with the conventional imaging modality in breast cancer patients with dense breasts

Authors: Bom Sahn Kim, Byung In Moon, Eun Sook Cha

Published in: Annals of Nuclear Medicine | Issue 10/2012

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Abstract

Objective

The aim of this study was to evaluate the value of breast-specific gamma imaging (BSGI) as compared with mammography (MMG) and ultrasonography (US).

Methods

This study retrospectively enrolled 121 women with breast cancer (45.0 ± 8.1 years) and dense breasts (breast density >50 %). All patients underwent preoperative BSGI, MMG, and US, and the results were correlated with the biopsy results.

Results

In the 121 patients, 153 breast lesions were malignant tumors and 75 lesions were diagnosed as benign tumors. The sensitivity and specificity of BSGI were 92.2 and 89.3 %, while the values of MMG and US were 53.6 and 94.7 and 91.5 and 53.3 %, respectively (p < 0.0001 and p < 0.0004). In breast lesions ≤1 cm, the sensitivity and specificity of BSGI were 80.6 and 91.5 %, which were different from MMG and US, respectively (p < 0.0001 and p < 0.0003). Of 28 patients with 59 multiplicities, BSGI and US found 49 lesions and 51 lesions correctly. However, MMG detected only 26 lesions as malignancies.

Conclusion

Given the results of this study, women with dense breasts are not evaluated with MMG at all and went straight to US or MRI in order to minimize radiation exposure. Due to the high false-positive rate of these modalities, BSGI could then be utilized if the US or MRI are positive.
Literature
1.
2.
Kolb TM, Lichy J, Newhouse JH. Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations. Radiology. 2002;225(1):165–75.CrossRefPubMed
3.
Mandelson MT, Oestreicher N, Porter PL, White D, Finder CA, Taplin SH, et al. Breast density as a predictor of mammographic detection: comparison of interval- and screen-detected cancers. J Natl Cancer Inst. 2000;92(13):1081–7.CrossRefPubMed
4.
Berg WA, Gutierrez L, NessAiver MS, Carter WB, Bhargavan M, Lewis RS, et al. Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer. Radiology. 2004;233(3):830–49.CrossRefPubMed
5.
Berg WA, Blume JD, Cormack JB, Mendelson EB, Lehrer D, Bohm-Velez M, et al. Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer. JAMA. 2008;299(18):2151–63.CrossRefPubMed
6.
Khalkhali I, Mena I, Jouanne E, Diggles L, Venegas R, Block J, et al. Prone scintimammography in patients with suspicion of carcinoma of the breast. J Am Coll Surg. 1994;178(5):491–7.PubMed
7.
Lumachi F, Ferretti G, Povolato M, Marzola MC, Zucchetta P, Geatti O, et al. Accuracy of technetium-99m sestamibi scintimammography and X-ray mammography in premenopausal women with suspected breast cancer. Eur J Nucl Med. 2001;28(12):1776–80.CrossRefPubMed
8.
Babuccu O, Peksoy I, Kargi E, Hosnuter M, Ozdemir H, Gundogdu S, et al. The value of scintimammography in reduction mammaplasties: a preliminary study. Aesthetic Plast Surg. 2003;27(4):296–300.CrossRefPubMed
9.
Khalkhali I, Baum JK, Villanueva-Meyer J, Edell SL, Hanelin LG, Lugo CE, et al. (99m)Tc sestamibi breast imaging for the examination of patients with dense and fatty breasts: multicenter study. Radiology. 2002;222(1):149–55.CrossRefPubMed
10.
Taillefer R. Clinical applications of 99mTc-sestamibi scintimammography. Semin Nucl Med. 2005;35(2):100–15.CrossRefPubMed
11.
Arslan N, Ozturk E, Ilgan S, Urhan M, Karacalioglu O, Pekcan M, et al. 99Tcm-MIBI scintimammography in the evaluation of breast lesions and axillary involvement: a comparison with mammography and histopathological diagnosis. Nucl Med Commun. 1999;20(4):317–25.CrossRefPubMed
12.
Palmedo H, Grunwald F, Bender H, Schomburg A, Mallmann P, Krebs D, et al. Scintimammography with technetium-99m methoxyisobutylisonitrile: comparison with mammography and magnetic resonance imaging. Eur J Nucl Med. 1996;23(8):940–6.CrossRefPubMed
13.
Brem RF, Floerke AC, Rapelyea JA, Teal C, Kelly T, Mathur V. Breast-specific gamma imaging as an adjunct imaging modality for the diagnosis of breast cancer. Radiology. 2008;247(3):651–7.CrossRefPubMed
14.
Brem RF, Schoonjans JM, Kieper DA, Majewski S, Goodman S, Civelek C. High-resolution scintimammography: a pilot study. J Nucl Med. 2002;43(7):909–15.PubMed
15.
Weigert JM, Bertrand ML, Lanzkowsky L, Stern LH, Kieper DA. Results of a multicenter patient registry to determine the clinical impact of breast-specific gamma imaging, a molecular breast imaging technique. AJR Am J Roentgenol. 2012;198(1):W69–75.CrossRefPubMed
16.
Brem RF, Shahan C, Rapleyea JA, Donnelly CA, Rechtman LR, Kidwell AB, et al. Detection of occult foci of breast cancer using breast-specific gamma imaging in women with one mammographic or clinically suspicious breast lesion. Acad Radiol. 2010;17(6):735–43.CrossRefPubMed
17.
Iagaru A, Masamed R, Keesara S, Conti PS. Breast MRI and 18F FDG PET/CT in the management of breast cancer. Ann Nucl Med. 2007;21(1):33–8.CrossRefPubMed
18.
Kim BS. Usefulness of breast-specific gamma imaging as an adjunct modality in breast cancer patients with dense breast: a comparative study with MRI. Ann Nucl Med. 2012;26(2):131–7.CrossRefPubMed
19.
Anastassiades O, Iakovou E, Stavridou N, Gogas J, Karameris A. Multicentricity in breast cancer. A study of 366 cases. Am J Clin Pathol. 1993;99(3):238–43.PubMed
20.
Ustaalioglu BO, Bilici A, Kefeli U, Seker M, Oncel M, Gezen C, et al. The importance of multifocal/multicentric tumor on the disease-free survival of breast cancer patients: single center experience. Am J Clin Oncol. 2011 (Epub ahead of print).
21.
Biglia N, Bounous VE, Martincich L, Panuccio E, Liberale V, Ottino L, et al. Role of MRI (magnetic resonance imaging) versus conventional imaging for breast cancer presurgical staging in young women or with dense breast. Eur J Surg Oncol. 2011;37(3):199–204.CrossRefPubMed
22.
Keto JL, Kirstein L, Sanchez DP, Fulop T, McPartland L, Cohen I, et al. MRI versus breast-specific gamma imaging (BSGI) in newly diagnosed ductal cell carcinoma-in situ: a prospective head-to-head trial. Ann Surg Oncol. 2012;19(1):249–52.CrossRefPubMed
23.
Drew PJ, Turnbull LW, Chatterjee S, Read J, Carleton PJ, Fox JN, et al. Prospective comparison of standard triple assessment and dynamic magnetic resonance imaging of the breast for the evaluation of symptomatic breast lesions. Ann Surg. 1999;230(5):680–5.CrossRefPubMed
24.
Brem RF, Petrovitch I, Rapelyea JA, Young H, Teal C, Kelly T. Breast-specific gamma imaging with 99mTc-Sestamibi and magnetic resonance imaging in the diagnosis of breast cancer—a comparative study. Breast J. 2007;13(5):465–9.CrossRefPubMed
Metadata
Title
A comparative study of breast-specific gamma imaging with the conventional imaging modality in breast cancer patients with dense breasts
Authors
Bom Sahn Kim
Byung In Moon
Eun Sook Cha
Publication date
01-12-2012
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 10/2012
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-012-0649-5

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