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01-12-2019 | Case Report

Laryngeal Epstein–Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child

Authors: Ciro Dantas Soares, Roman Carlos, Juan Pablo Díaz Molina, Thayná Melo de Lima Morais, Oslei Paes de Almeida

Published in: Head and Neck Pathology | Issue 4/2019

Abstract

Smooth muscle tumors associated with Epstein–Barr virus infections (EBV–SMT) of laryngeal origin are exceedingly rare and have been reported in few adult patients, but not in children. This reported case describes a lesion found in the larynx of an 8-year-old Guatemalan undernourished girl. Microscopically, the lesion showed a highly cellular mesenchymal spindle cell tumor, containing frequent lymphocytes. The immunohistochemical analysis revealed positivity for α-smooth muscle actin and h-caldesmon. In addition, most of the tumor cells were positive for EBV by in situ hybridization. To the best of the author’s knowledge, this is the first literature-reported case of laryngeal EBV–SMT occurring in an undernourished child.

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Title: Laryngeal Epstein–Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child
Authors: Ciro Dantas Soares
Roman Carlos
Juan Pablo Díaz Molina
Thayná Melo de Lima Morais
Oslei Paes de Almeida
Publication date: 01-12-2019
Publisher: Springer US
Published in: Head and Neck Pathology / Issue 4/2019
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-018-0960-0

At a glance: The STEP trials

Springer Medicine

Laryngeal Epstein–Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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