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01-12-2019 | Sine qua non Clinicopathologic Correlation

Embryonal Rhabdomyosarcoma (Botryoid Subtype) Affecting the Buccal Mucosa

Authors: John Lennon Silva Cunha, Francisco De Assis Almeida Lima-Júnior, Wilson Déda Gonçalves Júnior, Thiago De Santana Santos, Ericka Janine Dantas Da Silveira, Silvia Ferreira De Sousa, Ricardo Luiz Cavalcanti De Albuquerque-Júnior

Published in: Head and Neck Pathology | Issue 4/2019

Abstract

Rhabdomyosarcoma (RMS) is a rare oral malignant soft tissue tumor whose pathological features may influence the clinical behavior, treatment and prognosis of the lesion. We report a case of a 13-year-old female patient, presenting an asymptomatic polypoid swelling in the left buccal mucosa that was approximately 2.5 cm in diameter and 3 months evolution. The presumptive diagnosis was fibrous hyperplasia and an excisional biopsy was carried out. Pathologic analysis revealed proliferation of predominantly ovoid cells, with eosinophilic cytoplasm and pleomorphic nuclei, arranged in subepithelial cambium layer. The mucosal surface presented a papillary–verrucous appearance. Immunohistochemical analysis revealed intense positivity for desmin, myogenin and Ki-67. The diagnosis was of embryonal RMS (botryoid variant). The patient was subjected to complementary chemotherapy and radiotherapy, with no evidence of recurrence or metastatic disease after 12 months follow-up. A discussion on the clinical, histopathological, immunohistochemical and therapeutic aspects of botryoid RMS will be provided.

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Title: Embryonal Rhabdomyosarcoma (Botryoid Subtype) Affecting the Buccal Mucosa
Authors: John Lennon Silva Cunha
Francisco De Assis Almeida Lima-Júnior
Wilson Déda Gonçalves Júnior
Thiago De Santana Santos
Ericka Janine Dantas Da Silveira
Silvia Ferreira De Sousa
Ricardo Luiz Cavalcanti De Albuquerque-Júnior
Publication date: 01-12-2019
Publisher: Springer US
Published in: Head and Neck Pathology / Issue 4/2019
Electronic ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-018-0957-8

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Embryonal Rhabdomyosarcoma (Botryoid Subtype) Affecting the Buccal Mucosa

Abstract

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