Skip to main content
Top
Published in: Hepatology International 5/2017

01-09-2017 | Editorial

Pathology of idiopathic non-cirrhotic portal hypertension

Author: Masayoshi Kage

Published in: Hepatology International | Issue 5/2017

Login to get access

Excerpt

Idiopathic non-cirrhotic portal hypertension (INCPH) represents diseases in which splenomegaly, anemia, and portal hypertension occur but no causative disease, such as liver cirrhosis, occlusion of the extrahepatic portal vein/hepatic vein, blood disease, parasitic disease, granulomatous liver disease, or congenital hepatic fibrosis, can be demonstrated [1, 2]. …
Literature
1.
go back to reference Schouten JN, Garcia-Pagan JC, Valla DC, Janseen HL. Idiopathic portal hypertension. Hepatology. 2011;54:1071–1081CrossRefPubMed Schouten JN, Garcia-Pagan JC, Valla DC, Janseen HL. Idiopathic portal hypertension. Hepatology. 2011;54:1071–1081CrossRefPubMed
2.
go back to reference Khanna R, Sarin SK. Non-cirrhotic portal hypertension—diagnosis and management. J Hepatol. 2014;60:421–441CrossRefPubMed Khanna R, Sarin SK. Non-cirrhotic portal hypertension—diagnosis and management. J Hepatol. 2014;60:421–441CrossRefPubMed
3.
go back to reference Hidaka H, Ohbu M, Kokubu S, Shibuya A, Saigenji K, Okayasu I. Hepatocellular carcinoma associated with idiopathic portal hypertension: review of large nodules in seven non-cirrhotic portal hypertensive livers. J Gastroenterol Hepatol. 2005;20:493–495CrossRefPubMed Hidaka H, Ohbu M, Kokubu S, Shibuya A, Saigenji K, Okayasu I. Hepatocellular carcinoma associated with idiopathic portal hypertension: review of large nodules in seven non-cirrhotic portal hypertensive livers. J Gastroenterol Hepatol. 2005;20:493–495CrossRefPubMed
4.
go back to reference Sato Y, Sawada S, Kozaka K, Harada K, Sasaki M, Matsui O, Nakanuma Y. Significance of enhanced expression of nitric oxide syntheses in splenic sinus lining cells in altered portal hemodynamics of idiopathic portal hypertension. Dig Dis Sci. 2007;52:1987–1989CrossRefPubMed Sato Y, Sawada S, Kozaka K, Harada K, Sasaki M, Matsui O, Nakanuma Y. Significance of enhanced expression of nitric oxide syntheses in splenic sinus lining cells in altered portal hemodynamics of idiopathic portal hypertension. Dig Dis Sci. 2007;52:1987–1989CrossRefPubMed
6.
go back to reference Kitao A, Sato Y, Sawada-Kitamura S, Harada K, Sasaki M, Morikawa H, Shiomi S, Honda M, Matsui O, Nakanuma Y. Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension. Am J Pathol. 2009;175:616–626. doi:10.2353/ajpath.2009.081061 CrossRefPubMedPubMedCentral Kitao A, Sato Y, Sawada-Kitamura S, Harada K, Sasaki M, Morikawa H, Shiomi S, Honda M, Matsui O, Nakanuma Y. Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension. Am J Pathol. 2009;175:616–626. doi:10.​2353/​ajpath.​2009.​081061 CrossRefPubMedPubMedCentral
7.
go back to reference Verheij J, Schouten JNL, Komuta M, et al. Histological features in western patients with idiopathic non-cirrhotic portal hypertension. Histopathology. 2013;62:1083–1091CrossRefPubMed Verheij J, Schouten JNL, Komuta M, et al. Histological features in western patients with idiopathic non-cirrhotic portal hypertension. Histopathology. 2013;62:1083–1091CrossRefPubMed
8.
go back to reference Nayak NC, Jain D, Saigal S, Soin AS. Non-cirrhotic portal fibrosis: one disease with many names? An analysis from morphological study of native explant livers with end stage chronic liver disease. J ClinPathol. 2011;64(7):592–598 Nayak NC, Jain D, Saigal S, Soin AS. Non-cirrhotic portal fibrosis: one disease with many names? An analysis from morphological study of native explant livers with end stage chronic liver disease. J ClinPathol. 2011;64(7):592–598
9.
go back to reference Lee H, Ainechi S, Singh M, et al. Histological spectrum of idiopathic noncirrhotic portal hypertension in liver biopsies from dialysis patients. Int J SurgPathol. 2015;23:439–446 Lee H, Ainechi S, Singh M, et al. Histological spectrum of idiopathic noncirrhotic portal hypertension in liver biopsies from dialysis patients. Int J SurgPathol. 2015;23:439–446
10.
go back to reference Wanless IR, Godwin TA, Allen F, Feder A. Nodular regenative hyperplasia of the liver in hematologic disorders: a possible response to obliterative portal venopathy. Medicine (Batimore). 1980;59:367–379CrossRef Wanless IR, Godwin TA, Allen F, Feder A. Nodular regenative hyperplasia of the liver in hematologic disorders: a possible response to obliterative portal venopathy. Medicine (Batimore). 1980;59:367–379CrossRef
11.
go back to reference Zuo C, Chumbalkar V, Ells PF, Bonville DJ, Lee H. Prevalence of histological features of idiopathic noncirrhotic portal hypertension in general population: a retrospective study of incidental liver biopsies. Hepatol Int. 2017;. doi:10.1007/s12072-017-9801-6 (epub ahead of print) PubMed Zuo C, Chumbalkar V, Ells PF, Bonville DJ, Lee H. Prevalence of histological features of idiopathic noncirrhotic portal hypertension in general population: a retrospective study of incidental liver biopsies. Hepatol Int. 2017;. doi:10.​1007/​s12072-017-9801-6 (epub ahead of print) PubMed
12.
go back to reference Guido Maria, et al. Obliterative portal venopathy without portal hypertension: an underestimated condition. Liver Int. 2016;36:454–460CrossRefPubMed Guido Maria, et al. Obliterative portal venopathy without portal hypertension: an underestimated condition. Liver Int. 2016;36:454–460CrossRefPubMed
13.
go back to reference Cazals-Hatem D, Hillaire S, Rudler M, Plessier A, Paradis V, Condat B, Francoz C, Denninger MH, Durand F, Bedossa P, Valla DC. Obliterative portal venopathy: portal hypertension is not always present at diagnosis. J Hepatol. 2011;54:455–461CrossRefPubMed Cazals-Hatem D, Hillaire S, Rudler M, Plessier A, Paradis V, Condat B, Francoz C, Denninger MH, Durand F, Bedossa P, Valla DC. Obliterative portal venopathy: portal hypertension is not always present at diagnosis. J Hepatol. 2011;54:455–461CrossRefPubMed
14.
go back to reference Wanless IR, Bernier V, Seger M. Intrahepatic portal sclerosis in patients without history of liver disease: an autopsy study. Am J Pathol. 1982;106:63–70PubMedPubMedCentral Wanless IR, Bernier V, Seger M. Intrahepatic portal sclerosis in patients without history of liver disease: an autopsy study. Am J Pathol. 1982;106:63–70PubMedPubMedCentral
15.
go back to reference Fukuda K, Kage M, Arakawa M, Nakashima T. Portal vein or hepatic vein? A curious aberrant vasculature in the liver with idiopathic portal hypertension. Acta Pathol Jpn. 1985;5:885–897 Fukuda K, Kage M, Arakawa M, Nakashima T. Portal vein or hepatic vein? A curious aberrant vasculature in the liver with idiopathic portal hypertension. Acta Pathol Jpn. 1985;5:885–897
16.
go back to reference Ohbu M, Okudaira M, Watanabe K, Kaneko S, Takai T. Histopathological study of intrahepatic aberrant vessels in cases of noncirrhotic portal hypertension. Hepatology. 1994;20:302–308CrossRefPubMed Ohbu M, Okudaira M, Watanabe K, Kaneko S, Takai T. Histopathological study of intrahepatic aberrant vessels in cases of noncirrhotic portal hypertension. Hepatology. 1994;20:302–308CrossRefPubMed
17.
go back to reference Sato Y, Harada K, Sasaki M, Nakanuma Y. Altered intrahepatic microcirculation of idiopathic portal hypertension in relation to glutamine synthetase expression. Hepatol Res. 2015;45:1323–1330CrossRefPubMed Sato Y, Harada K, Sasaki M, Nakanuma Y. Altered intrahepatic microcirculation of idiopathic portal hypertension in relation to glutamine synthetase expression. Hepatol Res. 2015;45:1323–1330CrossRefPubMed
Metadata
Title
Pathology of idiopathic non-cirrhotic portal hypertension
Author
Masayoshi Kage
Publication date
01-09-2017
Publisher
Springer India
Published in
Hepatology International / Issue 5/2017
Print ISSN: 1936-0533
Electronic ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-017-9823-0

Other articles of this Issue 5/2017

Hepatology International 5/2017 Go to the issue