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Hepatology International
Published in: Hepatology International 2/2010

01-06-2010 | Case Report

Acute hepatitis B despite a previous high titer of anti-HBs

Authors: Resat Ozaras, Cem Ar, Seniz Ongoren, Bilgul Mete, Fehmi Tabak, Ali Mert, Recep Ozturk

Published in: Hepatology International | Issue 2/2010

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Abstract

Introduction

Loss of HBsAg and development of surface and core antibodies represent clinical cure. However, recent evidence suggests that hepatitis B virus (HBV) persists in a latent state even in those with mounted protective antibodies. After significant immunosuppression, anti-HBs may decrease and HBsAg may reappear (reverse seroconversion). Reverse seroconversion of HBV has been observed in association with hematopoietic stem cell transplantation, renal transplantation, intensive chemotherapy, human immunodeficiency infection, or rituximab usage.

Case report

We present here a case study of a patient with a previous high titer of anti-HBs who later developed HBV reactivation following intensive chemotherapy for leukemia.

Conclusion

We conclude that in immunosuppressed patients with a history of HBV infection may carry a risk for reverse seroconversion and monitoring anti-HBs levels may help recognising this risk.
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Metadata
Title
Acute hepatitis B despite a previous high titer of anti-HBs
Authors
Resat Ozaras
Cem Ar
Seniz Ongoren
Bilgul Mete
Fehmi Tabak
Ali Mert
Recep Ozturk
Publication date
01-06-2010
Publisher
Springer-Verlag
Published in
Hepatology International / Issue 2/2010
Print ISSN: 1936-0533
Electronic ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-010-9177-3

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