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Medical Oncology
Published in: Medical Oncology 4/2015

Open Access 01-04-2015 | Original Paper

Liposomal cytarabine in the prophylaxis and treatment of CNS lymphoma: toxicity analysis in a retrospective case series study conducted at Polish Lymphoma Research Group Centers

Authors: Wojciech Jurczak, Renata Kroll-Balcerzak, Sebastian Giebel, Maciej Machaczka, Agnieszka Giza, Tomasz Ogórka, Szymon Fornagiel, Justyna Rybka, Tomasz Wróbel, Beata Kumiega, Aleksander B. Skotnicki, Mieczysław Komarnicki

Published in: Medical Oncology | Issue 4/2015

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Abstract

Lymphomas with primary or secondary involvement of central nervous system (CNS) have poor prognosis despite specific treatment protocols which include whole brain radiotherapy and high-dose systemic and/or intrathecal chemotherapy. Toxicity of intrathecal liposomal cytarabine-based regimens collected between November 2006 and January 2012 was assessed retrospectively. Data from 120 adult lymphoma patients with, or at high risk of CNS involvement who received intrathecal liposomal cytarabine-based regimens at six Polish Lymphoma Research Group centres between November 2006 and January 2012 were assessed retrospectively. Patients were divided into three cohorts: A (high risk of CNS disease, n = 88), B (cerebrospinal fluid pleocytosis without neurological symptoms or pathological imaging findings, n = 7), and C (CNS disease/neurological involvement; n = 25). In all examined groups, toxicity of treatment was found to be acceptable (including the prophylactic setting). None of the patients in cohorts A or B who took intrathecal liposomal cytarabine 50 mg, repeated every 2–4 weeks (mean 3.8 doses) had experienced a CNS relapse at a median follow-up time of 3 years. Patients in cohort C had a 76 % overall neurological response rate (including a 40 % complete response rate) and median overall survival of 4.8 years. Regimens incorporating liposomal cytarabine seem to be safe and effective treatments for lymphomas with CNS involvement.
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Metadata
Title
Liposomal cytarabine in the prophylaxis and treatment of CNS lymphoma: toxicity analysis in a retrospective case series study conducted at Polish Lymphoma Research Group Centers
Authors
Wojciech Jurczak
Renata Kroll-Balcerzak
Sebastian Giebel
Maciej Machaczka
Agnieszka Giza
Tomasz Ogórka
Szymon Fornagiel
Justyna Rybka
Tomasz Wróbel
Beata Kumiega
Aleksander B. Skotnicki
Mieczysław Komarnicki
Publication date
01-04-2015
Publisher
Springer US
Published in
Medical Oncology / Issue 4/2015
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-015-0520-3

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