Top

Published in:

01-06-2013 | Short Communication

Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon

Authors: Shagufta Shaheen, Achuta K. Guddati

Published in: Medical Oncology | Issue 2/2013

Abstract

Mucosa-associated lymphoid tissue (MALT)-type lymphomas most commonly occur in the stomach and have been associated with Helicobacter pylori infection. However, MALT-type lymphoma of the colon is a rare entity. It commonly manifests with symptoms of weight loss, low-grade fever, constipation, melena, and hematochezia. Unlike gastric lymphoma, it is difficult to detect MALT-type lymphoma of the colon by imaging. Colonoscopy may reveal lesions whose biopsy most commonly shows abundant B lymphocytes. There is no universal immunohistochemistry profile for MALT-type lymphoma but CD 20 staining is commonly seen. Trisomies and translocations have been described and their presence has been correlated with treatment response. Due to the rarity of colonic MALT-type lymphoma, no standard guidelines are available for its management. It often occurs individually and rarely occurs simultaneously with concurrent colon adenocarcinoma. This case report describes the presentation and clinical course of a secondary MALT-type lymphoma in a patient who underwent colectomy for a prior colon adenocarcinoma.

Sipos F, Muzes G. Isolated lymphoid follicles in colon: switch points between inflammation and colorectal cancer? World J Gastroenterol. 2011;17(13):1666–73. doi:10.3748/wjg.v17.i13.1666.PubMedCrossRef

Featherstone C. M cells: portals to the mucosal immune system. Lancet. 1997;350(9086):1230. doi:10.1016/S0140-6736(05)63467-8.PubMedCrossRef

Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983;52(8):1410–6.PubMedCrossRef

d’Amore F, Brincker H, Gronbaek K, Thorling K, Pedersen M, Jensen MK, Andersen E, Pedersen NT, Mortensen LS. Non-Hodgkin’s lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis. Danish lymphoma study group. J Clin Oncol. 1994;12(8):1673–84.PubMed

Stolte M, Bayerdorffer E, Morgner A, Alpen B, Wundisch T, Thiede C, Neubauer A (2002) Helicobacter and gastric MALT lymphoma. Gut 50 Suppl 3:III19–24.

Wundisch T, Dieckhoff P, Greene B, Thiede C, Wilhelm C, Stolte M, Neubauer A (2012) Second cancers and residual disease in patients treated for gastric mucosa-associated lymphoid tissue lymphoma by Helicobacter pylori eradication and followed for 10 years. Gastroenterology 143 (4):936-942; quiz e913–e934. doi:10.1053/j.gastro.2012.06.035.

Auner HW, Beham-Schmid C, Lindner G, Fickert P, Linkesch W, Sill H. Successful nonsurgical treatment of primary mucosa-associated lymphoid tissue lymphoma of colon presenting with multiple polypoid lesions. Am J Gastroenterol. 2000;95(9):2387–9. doi:10.1111/j.1572-0241.2000.02343.x.PubMedCrossRef

Ferlay J, Shin HR, Bray F, Forman D, Mathers C. Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN. Int J Cancer. 2008;127(12):2893–917. doi:10.1002/ijc.25516.CrossRef

Psyrri A, Papageorgiou S, Economopoulos T. Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management. Ann Oncol. 2008;19(12):1992–9. doi:10.1093/annonc/mdn525.PubMedCrossRef

10.

Ahlawat S, Kanber Y, Charabaty-Pishvaian A, Ozdemirli M, Cohen P, Benjamin S, Haddad N. Primary mucosa-associated lymphoid tissue (MALT) lymphoma occurring in the rectum: a case report and review of the literature. South Med J. 2006;99(12):1378–84.PubMedCrossRef

11.

Arnold IC, Hitzler I, Engler D, Oertli M, Agger EM, Muller A. The C-terminally encoded, MHC class II-restricted T cell antigenicity of the Helicobacter pylori virulence factor CagA promotes gastric preneoplasia. J Immunol. 2011;186(11):6165–72. doi:10.4049/jimmunol.1003472.PubMedCrossRef

12.

Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, Isaacson PG. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993;342(8871):575–7.PubMedCrossRef

13.

Dohden K, Kaizaki Y, Hosokawa O, Hayashi H, Hattori M. Regression of rectal mucosa-associated lymphoid tissue lymphoma but persistence of Helicobacter pylori infection of gastric mucosa after administration of levofloxacin: report of a case. Dis Colon Rectum. 2004;47(9):1544–6. doi:10.1007/s10350-004-0575-2.PubMedCrossRef

14.

Takenaka R, Tomoda J, Sakata T, Ichiba T, Motoi M, Mizuno M, Tsuji T. Mucosa-associated lymphoid tissue lymphoma of the rectum that regressed spontaneously. J Gastroenterol Hepatol. 2000;15(3):331–5.PubMedCrossRef

15.

Jezersek Novakovic B, Vovk M, Juznic Setina T. A single-center study of treatment outcomes and survival in patients with primary gastric lymphomas between 1990 and 2003. Ann Hematol. 2006;85(12):849–56. doi:10.1007/s00277-006-0172-7.PubMedCrossRef

16.

Nakamura T, Seto M, Tajika M, Kawai H, Yokoi T, Yatabe Y, Nakamura S (2008) Clinical features and prognosis of gastric MALT lymphoma with special reference to responsiveness to H. pylori eradication and API2-MALT1 status. Am J Gastroenterol 103 (1):62–70. doi:10.1111/j.1572-0241.2007.01521.x.

17.

Fischbach W. Long-term follow-up of gastric lymphoma after stomach conserving treatment. Best Pract Res Clin Gastroenterol. 2010;24(1):71–7. doi:10.1016/j.bpg.2009.12.005.PubMedCrossRef

18.

Farinha P, Gascoyne RD. Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma. J Clin Oncol. 2005;23(26):6370–8. doi:10.1200/JCO.2005.05.011.PubMedCrossRef

19.

Bautista-Quach MA, Ake CD, Chen M, Wang J. Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features. J Gastrointest Oncol. 2012;3(3):209–25. doi:10.3978/j.issn.2078-6891.2012.024.PubMed

20.

Kobayashi T, Takahashi N, Hagiwara Y, Tamaru J, Kayano H, Jin-nai I, Bessho M, Niitsu N. Successful radiotherapy in a patient with primary rectal mucosa-associated lymphoid tissue lymphoma without the API2-MALT1 fusion gene: a case report and review of the literature. Leuk Res. 2008;32(1):173–5. doi:10.1016/j.leukres.2007.04.017.PubMedCrossRef

21.

Amouri A, Chtourou L, Mnif L, Mdhaffar M, Abid M, Ayedi L, Daoud J, Elloumi M, Boudawara T, Tahri N. MALT lymphoma of the rectum: a case report treated by radiotherapy. Cancer Radiother. 2009;13(1):61–4. doi:10.1016/j.canrad.2008.11.001.PubMedCrossRef

22.

Sahasrabudhe N, Khirwadkar N, Prescott R. Synchronous adenocarcinoma and marginal zone B-cell lymphoma of the colon: a case report. Diagn Histopathol. 2009;15(6):318–22.CrossRef

23.

Argyropoulos T, Foukas P, Kefala M, Xylardistos P, Papageorgiou S, Machairas N, Boltetsou E, Machairas A, Panayiotides IG. Simultaneous occurrence of colonic adenocarcinoma and MALT lymphoma: a series of three cases. World J Gastrointest Oncol. 2012;4(4):89–93. doi:10.4251/wjgo.v4.i4.89.PubMedCrossRef

Title: Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon
Authors: Shagufta Shaheen
Achuta K. Guddati
Publication date: 01-06-2013
Publisher: Springer US
Published in: Medical Oncology / Issue 2/2013
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-013-0502-2

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2013

Secondary mutations of c-KIT contribute to acquired resistance to imatinib and decrease efficacy of sunitinib in Chinese patients with gastrointestinal stromal tumors

MicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery

Prospective phase II trial of neoadjuvant chemo-radiotherapy with Oxaliplatin and Capecitabine in locally advanced rectal cancer (XELOXART)

Diagnostic value of mesothelin in pleural fluids: comparison with CYFRA 21-1 and CEA

Central nervous system prophylaxis in patients with aggressive diffuse large B cell lymphoma: An analysis of 3,258 patients in a single center

Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating Slug

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page