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Medical Oncology
Published in: Medical Oncology 1/2013

Open Access 01-03-2013 | Original Paper

Effects of EHD2 interference on migration of esophageal squamous cell carcinoma

Authors: Mei Li, Xiaojing Yang, Jianguo Zhang, Hui Shi, Qinglei Hang, Xianting Huang, Guoliang Liu, Junya Zhu, Song He, Huijie Wang

Published in: Medical Oncology | Issue 1/2013

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Abstract

C-Terminal EH domain-containing protein 2 (EHD2) of the EHD family is associated with plasma membrane. We investigated the expression of EHD2 in human esophageal squamous cell carcinoma (ESCC) and the EHD2 expression to study the therapeutic effect of chemotherapy drugs. Western blot and immunohistochemistry were used to measure the expression of EHD2 protein in ESCC and adjacent normal tissue in 98 patients. EHD2 protein level was reduced in ESCC tissues in comparison with adjacent normal tissues. Under-expression of EHD2 increased the motility property of ESCC cell TE1 in vitro by wound-healing assays and transwell migration assays, and it was concurrent with the decreased expression of epithelial marker E-cadherin. Under-expression of EHD2 in TE1 can cause resistance to cisplatin. Our results suggested that EHD2 low expression is involved in the pathogenesis of ESCC, and it might be a favorable independent poor prognostic parameter for ESCC.
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Metadata
Title
Effects of EHD2 interference on migration of esophageal squamous cell carcinoma
Authors
Mei Li
Xiaojing Yang
Jianguo Zhang
Hui Shi
Qinglei Hang
Xianting Huang
Guoliang Liu
Junya Zhu
Song He
Huijie Wang
Publication date
01-03-2013
Publisher
Springer US
Published in
Medical Oncology / Issue 1/2013
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-012-0396-4

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