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Medical Oncology
Published in: Medical Oncology 3/2012

01-09-2012 | Short Communication

Additional chromosomal abnormalities detected by array comparative genomic hybridization in AML

Authors: Ana Rosa S. Costa, Sintia I. Belangero, Maria Isabel Melaragno, Maria de Lourdes Chauffaille

Published in: Medical Oncology | Issue 3/2012

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Abstract

Improved outcome of acute myeloid leukemia (AML) depends on the better differentiation of subtypes to predict treatment response and the identification of new target for treatment. In this study, array comparative genomic hybridization (aCGH) was used to distinguish eight cases of AML cases. Validation was performed by FISH and quantitative genomic PCR. The aCGH revealed new large and small recurrent genomic imbalances, such as gains of 1p36, 10q26, 11p15, 20q13, 22q23, harboring many proto-oncogenes. These results better define genetically the studied cases and could be used to understand the multiple phenomena involved in leukemogenesis.
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Metadata
Title
Additional chromosomal abnormalities detected by array comparative genomic hybridization in AML
Authors
Ana Rosa S. Costa
Sintia I. Belangero
Maria Isabel Melaragno
Maria de Lourdes Chauffaille
Publication date
01-09-2012
Publisher
Springer US
Published in
Medical Oncology / Issue 3/2012
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-011-0108-5

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