Skip to main content
Top
Published in: Medical Oncology 1/2011

01-12-2011

Activity of trabectidin in desmoplastic small round cell tumor

Published in: Medical Oncology | Special Issue 1/2011

Login to get access

Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive cancer that typically arises in teenage boys. As a result of its low prevalence, there have been few studies of its treatment and impact on survival. Here, we report the case of a patient who was refractory to multiple drugs but remains stable with trabectedin. To our knowledge, this is the first published report that supports antitumoral activity of trabectedin in DSRCT.
Literature
1.
go back to reference Stuart-Buttle CE, Smart CJ, Pritchard S, Martin D, Welch IM. Desmoplastic small round cell tumour: a review of literature and treatment options. Surg Oncol. 2008;17(2):107–12.PubMedCrossRef Stuart-Buttle CE, Smart CJ, Pritchard S, Martin D, Welch IM. Desmoplastic small round cell tumour: a review of literature and treatment options. Surg Oncol. 2008;17(2):107–12.PubMedCrossRef
2.
go back to reference Tejerina González E, Corbacho Cuevas C, López García A, Bellas C, Sánchez V, Sánchez Ruiz A, de Álava E, Sanz E. Tumor intraabdominal desmoplásico de células pequeñas y redondas. Revisión de la literatura a propósito de un caso con estudio citológico, histopatológico, inmunohistoquímico y molecular. Oncología. 2007;30(1):25–31. Tejerina González E, Corbacho Cuevas C, López García A, Bellas C, Sánchez V, Sánchez Ruiz A, de Álava E, Sanz E. Tumor intraabdominal desmoplásico de células pequeñas y redondas. Revisión de la literatura a propósito de un caso con estudio citológico, histopatológico, inmunohistoquímico y molecular. Oncología. 2007;30(1):25–31.
3.
go back to reference Landayi M, Gerald W. Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumors. Cancer Res. 1994;54:2837–40. Landayi M, Gerald W. Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumors. Cancer Res. 1994;54:2837–40.
4.
go back to reference Hassan I, et al. Intraabdominal desmoplastic small round cell tumours—a diagnostic and therapeutic challenge. Cancer. 2005;104(6):1264–70.PubMedCrossRef Hassan I, et al. Intraabdominal desmoplastic small round cell tumours—a diagnostic and therapeutic challenge. Cancer. 2005;104(6):1264–70.PubMedCrossRef
5.
go back to reference Livaditi E, Mavridis G, Soutis M, et al. Diffuse intraabdominal desmoplastic small round cell tumour: a ten-year experience. Eur J Pediatr Surg. 2006;16(6):423–7.PubMedCrossRef Livaditi E, Mavridis G, Soutis M, et al. Diffuse intraabdominal desmoplastic small round cell tumour: a ten-year experience. Eur J Pediatr Surg. 2006;16(6):423–7.PubMedCrossRef
6.
go back to reference Herrero AB, Martín-Castellanos C, Marco E, Gago F, Moreno S. Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin. Cancer Res. 2006;66(16):8155–62.PubMedCrossRef Herrero AB, Martín-Castellanos C, Marco E, Gago F, Moreno S. Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin. Cancer Res. 2006;66(16):8155–62.PubMedCrossRef
7.
go back to reference Grosso F, et al. Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study. Lancet Oncol. 2007;8:595–602.PubMedCrossRef Grosso F, et al. Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study. Lancet Oncol. 2007;8:595–602.PubMedCrossRef
8.
go back to reference Grosso F, et al. Trabectedin in myxoid liposarcomas (MLS): a long-term analysis of a single-institution series. Ann Oncol. 2009;20(8):1439–44.PubMedCrossRef Grosso F, et al. Trabectedin in myxoid liposarcomas (MLS): a long-term analysis of a single-institution series. Ann Oncol. 2009;20(8):1439–44.PubMedCrossRef
9.
go back to reference Bonfanti M, La Valle E, Fernández Sousa-Faro JM, Faircloth G, Caretti G, Mantonvani R, D’Incalci M. Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA. Anticancer Drug Des. 1999;14:179–86.PubMed Bonfanti M, La Valle E, Fernández Sousa-Faro JM, Faircloth G, Caretti G, Mantonvani R, D’Incalci M. Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA. Anticancer Drug Des. 1999;14:179–86.PubMed
10.
go back to reference Forni C, et al. Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. Mol Cancer Ther. 2009;8(2):449–57.PubMedCrossRef Forni C, et al. Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. Mol Cancer Ther. 2009;8(2):449–57.PubMedCrossRef
11.
go back to reference Tavecchio M, et al. Dynamics of cell cycle phase perturbations by trabectedin (ET-743) in nucleotide excision repair (NER)-deficient and NER-proficient cells, unravelled by a novel mathematical simulation approach. Cell Prolif. 2007;40:885–904.PubMedCrossRef Tavecchio M, et al. Dynamics of cell cycle phase perturbations by trabectedin (ET-743) in nucleotide excision repair (NER)-deficient and NER-proficient cells, unravelled by a novel mathematical simulation approach. Cell Prolif. 2007;40:885–904.PubMedCrossRef
12.
go back to reference Tavecchio M, et al. Role of homologous recombination in trabectedin-induced DNA damage. Eur J Cancer. 2008;44:609–18.PubMedCrossRef Tavecchio M, et al. Role of homologous recombination in trabectedin-induced DNA damage. Eur J Cancer. 2008;44:609–18.PubMedCrossRef
13.
go back to reference Soares DG, et al. Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743. PNAS. 2007;104(32):13062–7.PubMedCrossRef Soares DG, et al. Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743. PNAS. 2007;104(32):13062–7.PubMedCrossRef
Metadata
Title
Activity of trabectidin in desmoplastic small round cell tumor
Publication date
01-12-2011
Published in
Medical Oncology / Issue Special Issue 1/2011
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-010-9687-9

Other articles of this Special Issue 1/2011

Medical Oncology 1/2011 Go to the issue