Skip to main content
Top
Published in: Medical Oncology 3/2010

01-09-2010 | Original Paper

Two “childhood” malignancies in an elderly individual: a case report and discussion

Authors: Lohith S. Bachegowda, Gayathri Nagaraj, Petros D. Grivas, Lingyi Chen, Eugene Choi, Michael Styler

Published in: Medical Oncology | Issue 3/2010

Login to get access

Abstract

Rhabdomyosarcoma (RMS) is the most common soft-tissue tumor in childhood, but is extremely rare in elderly. We present a rare case of cardiac RMS, which developed 1 year after the diagnosis and management of acute lymphoblastic leukemia in a 68-year-old female. The occurrence of such phenomena is intriguing, especially in an individual without prior history of malignancy at a younger age. Through the review of the existing literature, we attempt to approach the pathogenesis and clinical manifestations of this rare clinical entity.
Literature
2.
go back to reference Pastore G, et al. Childhood soft tissue sarcomas incidence and survival in European children (1978–1997): report from the automated childhood cancer information system project. Eur J Cancer. 2006;42:2136–49.CrossRefPubMed Pastore G, et al. Childhood soft tissue sarcomas incidence and survival in European children (1978–1997): report from the automated childhood cancer information system project. Eur J Cancer. 2006;42:2136–49.CrossRefPubMed
3.
go back to reference Linker C, Damon L, Ries C, Navarro W. Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia. J Clin Oncol. 2002;20(10):2464–71.CrossRefPubMed Linker C, Damon L, Ries C, Navarro W. Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia. J Clin Oncol. 2002;20(10):2464–71.CrossRefPubMed
4.
go back to reference Pappo AS, et al. Two consecutive phase II window trials of irinotecan alone or in combination with vincristine for the treatment of metastatic rhabdomyosarcoma: the children’s oncology group. J Clin Oncol. 2007;25(4):362–9.CrossRefPubMed Pappo AS, et al. Two consecutive phase II window trials of irinotecan alone or in combination with vincristine for the treatment of metastatic rhabdomyosarcoma: the children’s oncology group. J Clin Oncol. 2007;25(4):362–9.CrossRefPubMed
5.
go back to reference Taylor PR, Reid MM, Proctor SJ. Acute lymphoblastic leukaemia in the elderly. Leuk Lymphoma. 1994;13(5–6):373–80.CrossRefPubMed Taylor PR, Reid MM, Proctor SJ. Acute lymphoblastic leukaemia in the elderly. Leuk Lymphoma. 1994;13(5–6):373–80.CrossRefPubMed
6.
7.
go back to reference Virgilio JF, et al. Acute lymphocytic leukemia (ALL) in elderly patients. Hematol Oncol. 1993;11(3):121–6.CrossRefPubMed Virgilio JF, et al. Acute lymphocytic leukemia (ALL) in elderly patients. Hematol Oncol. 1993;11(3):121–6.CrossRefPubMed
8.
go back to reference Robak T. Acute lymphoblastic leukaemia in elderly patients: biological characteristics and therapeutic approaches. Drugs Aging. 2004;21(12):779–91.CrossRefPubMed Robak T. Acute lymphoblastic leukaemia in elderly patients: biological characteristics and therapeutic approaches. Drugs Aging. 2004;21(12):779–91.CrossRefPubMed
9.
10.
go back to reference Blondeau P. Primary cardiac tumors—French studies of 533 cases. Thorac Cardiovasc Surg. 1990;38(Suppl 2):192–5.CrossRefPubMed Blondeau P. Primary cardiac tumors—French studies of 533 cases. Thorac Cardiovasc Surg. 1990;38(Suppl 2):192–5.CrossRefPubMed
11.
go back to reference Simon JH, Paulino AC, Ritchie JM, Mayr NA, Buatti JM. Presentation, prognostic factors and patterns of failure in adult rhabdomyosarcoma. Sarcoma. 2003;7(1):1–7.CrossRefPubMed Simon JH, Paulino AC, Ritchie JM, Mayr NA, Buatti JM. Presentation, prognostic factors and patterns of failure in adult rhabdomyosarcoma. Sarcoma. 2003;7(1):1–7.CrossRefPubMed
12.
go back to reference Hui KS, Green LK, Schmidt WA. Primary cardiac rhabdomyosarcoma: definition of a rare entity. Am J Cardiovasc Pathol. 1988;2(1):19–29.PubMed Hui KS, Green LK, Schmidt WA. Primary cardiac rhabdomyosarcoma: definition of a rare entity. Am J Cardiovasc Pathol. 1988;2(1):19–29.PubMed
13.
go back to reference Perchinsky MJ, Lichtenstein SV, Tyers GF. Primary cardiac tumors: forty years experience with 71 patients. Cancer. 1997;79(9):1809–15.CrossRefPubMed Perchinsky MJ, Lichtenstein SV, Tyers GF. Primary cardiac tumors: forty years experience with 71 patients. Cancer. 1997;79(9):1809–15.CrossRefPubMed
15.
go back to reference Camerieri A, Costa E, Scarano F, Colacino R. Primary cardiac rhabdomyosarcoma involving the mitral valve. G Ital Cardiol. 1992;22(9):1093–7.PubMed Camerieri A, Costa E, Scarano F, Colacino R. Primary cardiac rhabdomyosarcoma involving the mitral valve. G Ital Cardiol. 1992;22(9):1093–7.PubMed
16.
go back to reference Boice JD Jr, Curtis RE, Kleinerman RA, Flannery JT, Fraumeni JF Jr. Multiple primary cancers in connecticut, 1935–82. Yale J Biol Med. 1986;59(5):533–45.PubMed Boice JD Jr, Curtis RE, Kleinerman RA, Flannery JT, Fraumeni JF Jr. Multiple primary cancers in connecticut, 1935–82. Yale J Biol Med. 1986;59(5):533–45.PubMed
17.
go back to reference Li FP, Fraumeni JF Jr. Soft-tissue sarcomas, breast cancer and other neoplasms: a familial syndrome? Ann Intern Med. 1969;71:747–52.PubMed Li FP, Fraumeni JF Jr. Soft-tissue sarcomas, breast cancer and other neoplasms: a familial syndrome? Ann Intern Med. 1969;71:747–52.PubMed
18.
go back to reference Ali R. Rhabdomyosarcoma of the perianal region presenting as acute leukemia. Ann Hematol. 2004;83(11):729–30.CrossRefPubMed Ali R. Rhabdomyosarcoma of the perianal region presenting as acute leukemia. Ann Hematol. 2004;83(11):729–30.CrossRefPubMed
19.
go back to reference Morandi S, Manna A, Sabattini E, Porcellini A. Rhabdomyosarcoma presenting as acute leukemia. J Pediatr Hematol Oncol. 1996;18(3):305–7.CrossRefPubMed Morandi S, Manna A, Sabattini E, Porcellini A. Rhabdomyosarcoma presenting as acute leukemia. J Pediatr Hematol Oncol. 1996;18(3):305–7.CrossRefPubMed
20.
go back to reference Kahn DG. Rhabdomyosarcoma mimicking acute leukemia in an adult: report of a case with histologic, flow cytometric, cytogenetic, immunohistochemical, and ultrastructural studies. Arch Pathol Lab Med. 1998;122(4):375–8.PubMed Kahn DG. Rhabdomyosarcoma mimicking acute leukemia in an adult: report of a case with histologic, flow cytometric, cytogenetic, immunohistochemical, and ultrastructural studies. Arch Pathol Lab Med. 1998;122(4):375–8.PubMed
21.
go back to reference Merimsky O, et al. Multiple primary malignancies in association with soft tissue sarcomas. Cancer. 2001;91(7):1363–71.CrossRefPubMed Merimsky O, et al. Multiple primary malignancies in association with soft tissue sarcomas. Cancer. 2001;91(7):1363–71.CrossRefPubMed
Metadata
Title
Two “childhood” malignancies in an elderly individual: a case report and discussion
Authors
Lohith S. Bachegowda
Gayathri Nagaraj
Petros D. Grivas
Lingyi Chen
Eugene Choi
Michael Styler
Publication date
01-09-2010
Publisher
Springer US
Published in
Medical Oncology / Issue 3/2010
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-009-9299-4

Other articles of this Issue 3/2010

Medical Oncology 3/2010 Go to the issue