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Medical Oncology
Published in: Medical Oncology 3/2010

01-09-2010 | Original Paper

Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance

Authors: Yuanyuan Zhang, Junming Guo, Dong Li, Bingxiu Xiao, Ying Miao, Zhen Jiang, Hui Zhuo

Published in: Medical Oncology | Issue 3/2010

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Abstract

MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The expression levels of miR-31 in gastric cancer tissues were significantly lower than those in non-tumor tissues. This new information may help to clarify the molecular mechanisms involved in gastric carcinogenesis and to indicate that miR-31 may be a novel diagnostic biomarker of gastric cancer.
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Metadata
Title
Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance
Authors
Yuanyuan Zhang
Junming Guo
Dong Li
Bingxiu Xiao
Ying Miao
Zhen Jiang
Hui Zhuo
Publication date
01-09-2010
Publisher
Springer US
Published in
Medical Oncology / Issue 3/2010
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-009-9269-x

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