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01-09-2007 | Original Paper

Clinical stage-depending decrease of NK cell activity in multiple myeloma patients

Authors: Vladimir Jurisic, Tatjana Srdic, Gordana Konjevic, Olivera Markovic, Milica Colovic

Published in: Medical Oncology | Issue 3/2007

Abstract

Natural killer cells, as an important subpopulation of cells of the innate immune system have an essential role in defense of the rise and spread of malignancy. These cells have a CD3-CD16 + CD56+ phenotype and they are functionally defined by their ability to lyses tumor cells. We here show that decrease of NK cell activity was significantly associated with advanced clinical stage, increased lactate dehydrogenase (LDH), percentage infiltration of bone marrow with plasma cells, and β-2 microglobulin. The patients with higher NK cell activity at presentation after receiving VAD protocol have better cumulative survival in comparison with those with low NK cell activity.

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Title: Clinical stage-depending decrease of NK cell activity in multiple myeloma patients
Authors: Vladimir Jurisic
Tatjana Srdic
Gordana Konjevic
Olivera Markovic
Milica Colovic
Publication date: 01-09-2007
Publisher: Humana Press Inc
Published in: Medical Oncology / Issue 3/2007
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-007-0007-y

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