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01-03-2018 | Editorial

miR-200c as a Predictive Biomarker for 5-Fluorouracil Chemosensitivity in Colorectal Cancer

Authors: Fatemeh Karimi Dermani, Rezvan Najafi

Published in: Journal of Gastrointestinal Cancer | Issue 1/2018

Excerpt

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related mortality worldwide [1]. 5-Fluorouracil (5-FU) is generally administered for treating advanced colorectal cancer. However, the fact that some patients develop 5-FU resistance during the course of treatment is a major obstacle to effective therapy. Therefore, identifying the molecular mechanism is urgently needed to underlie the 5-FU resistance in CRC cells and develop novel diagnostic and prognostic biomarkers for 5-FU resistance that will improve the development of therapeutic strategies for CRC patients [2]. …

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Qian X, Howell P, Li X, Qin X, Gao L, Xi Y. MiR-200c sensitizes colorectal cancer cells to 5-FU through Bcl-2-involved apoptotic pathway. Cancer Res. 2010;70(8 Supplement):4042. https://doi.org/10.1158/1538-7445.AM10-4042.CrossRef

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Karimi Dermani F, Saidijam M, Amini R, Mahdavinezhad A, Heydari K, Najafi R. Resveratrol inhibits proliferation, invasion, and epithelial–mesenchymal transition by increasing miR-200c expression in HCT-116 colorectal cancer cells. J Cell Biochem. 2017;118(6):1547–55. https://doi.org/10.1002/jcb.25816.CrossRefPubMed

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Heydari K, Saidijam M, Reza Sharifi M, Asl SS, Shabab N, Najafi R. The effect of miR-200c inhibition on chemosensitivity (5-fluorouracil) in colorectal cancer. Pathol Oncol Res. 2017:1–7.

Title: miR-200c as a Predictive Biomarker for 5-Fluorouracil Chemosensitivity in Colorectal Cancer
Authors: Fatemeh Karimi Dermani
Rezvan Najafi
Publication date: 01-03-2018
Publisher: Springer US
Published in: Journal of Gastrointestinal Cancer / Issue 1/2018
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-017-0038-3

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