Published in:
01-03-2018 | Mgmt. of Complex Cases in GI Oncology
Primary Esophagogastric Neuroendocrine Carcinoma: a Retrospective Study from the Nottingham Upper Gastrointestinal Cancer Center
Authors:
Constantinos Savva, Philip Kaye, Irshad Soomro, Simon L. Parsons, Eleanor James, Srinivasan Madhusudan
Published in:
Journal of Gastrointestinal Cancer
|
Issue 1/2018
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Excerpt
Primary neuroendocrine carcinomas (NECs) of the esophagus and stomach are rare with an incidence ranging from 0.01 to 0.08 cases per 100,000 persons per year [
1,
2]. The prevalence of esophageal NEC ranges between 0.01 and 1.4% and gastric NEC between 2 and 3% of all gastroenteropancreatic neuroendocrine tumors [
1,
3‐
7]. The esophagus is the most common site for extrapulmonary small cell carcinomas with a prevalence between 18 and 44% [
6,
8‐
11]. Pathobiology of esophagogastric NEC is largely unknown [
12]. Although recent advances in diagnostic techniques have increased awareness of this rare disease, there is a lack of clinical evidence to inform appropriate management of these rare tumors [
13]. In the current study, we have explored the clinicopathological characteristics, treatment modalities, and survival of 24 patients with primary esophagogastric NEC who were treated in the Nottingham University Hospitals during a 9-year period (2007–2016). …
