Top

Published in:

01-03-2017 | Case Report

A Patient with HIV-Associated Metastatic Anal Squamous Cell Carcinoma Receiving Multimodality Therapy with Curative Intent: Case Report and Review of the Literature

Authors: Sunhee S. Kim, Grace E. Kim, Andrew H. Ko

Published in: Journal of Gastrointestinal Cancer | Issue 1/2017

Excerpt

Squamous cell carcinoma of the anus is a relatively rare malignancy that comprises roughly 0.4 % of all cancers and 2.5 % of gastrointestinal cancers in the USA [1, 2]. However, over the last decade, anal carcinoma incidence has steadily increased an average of 2.2 % each year; and unlike the downward trends observed in other HIV-associated cancers, despite the introduction of highly active antiretroviral therapy (HAART) in 1996, anal carcinoma incidence has not decreased in the HIV-positive population, resulting in total an estimated 7270 new cases and 1010 deaths in 2015 alone [3, 4]. …

Ryan DP, Compton CC, Mayer RJ. Carcinoma of the anal canal. N Engl J Med. 2000;342(11):792–800. doi:10.1056/nejm200003163421107.CrossRefPubMed

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5–29. doi:10.3322/caac.21254.CrossRefPubMed

Oehler-Janne C, Huguet F, Provencher S, Seifert B, Negretti L, Riener MO, et al. HIV-specific differences in outcome of squamous cell carcinoma of the anal canal: a multicentric cohort study of HIV-positive patients receiving highly active antiretroviral therapy. J Clin Oncol Off J Am Soc Clin Oncol. 2008;26(15):2550–7. doi:10.1200/jco.2007.15.2348.CrossRef

Howlader N, Noone A, Krapcho M. SEER Cancer Statistics Review, 1975–2012, National Cancer Institute. 2012 http://seer.cancer.gov/csr/1975_2012/.

Bartelink H, Roelofsen F, Eschwege F, Rougier P, Bosset JF, Gonzalez DG, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol Off J Am Soc Clin Oncol. 1997;15(5):2040–9.

Flam M, John M, Pajak TF, Petrelli N, Myerson R, Doggett S, et al. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol Off J Am Soc Clin Oncol. 1996;14(9):2527–39.

Glynne-Jones R, Meadows H, Wan S, Gollins S, Leslie M, Levine E, et al. EXTRA—a multicenter phase II study of chemoradiation using a 5 day per week oral regimen of capecitabine and intravenous mitomycin C in anal cancer. Int J Radiat Oncol Biol Phys. 2008;72(1):119–26. doi:10.1016/j.ijrobp.2007.12.012.CrossRefPubMed

Ajani JA, Carrasco CH, Jackson DE, Wallace S. Combination of cisplatin plus fluoropyrimidine chemotherapy effective against liver metastases from carcinoma of the anal canal. Am J Med. 1989;87(2):221–4.CrossRefPubMed

Faivre C, Rougier P, Ducreux M, Mitry E, Lusinchi A, Lasser P, et al. 5-fluorouracile and cisplatinum combination chemotherapy for metastatic squamous-cell anal cancer. Bull Cancer. 1999;86(10):861–5.PubMed

10.

Pawlik TM, Gleisner AL, Bauer TW, Adams RB, Reddy SK, Clary BM, et al. Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysis. Ann Surg Oncol. 2007;14(10):2807–16. doi:10.1245/s10434-007-9467-8.CrossRefPubMed

11.

Ioannidis O, Cheva A, Paraskevas G, Kotronis A, Papadimitriou N, Chatzopoulos S, et al. Basosquamous cell carcinoma of the anus. J Gastrointest Cancer. 2012;43 Suppl 1:S184–186. doi:10.1007/s12029-012-9392-3.CrossRefPubMed

12.

Tokar M, Bobilev D, Zalmanov S, Geffen DB, Walfisch S. Combined multimodal approach to the treatment of metastatic anal carcinoma: report of a case and review of the literature. Onkologie. 2006;29(1–2):30–2. doi:10.1159/000089798.PubMed

13.

Chiao EY, Giordano TP, Richardson P, El-Serag HB. Human immunodeficiency virus-associated squamous cell cancer of the anus: epidemiology and outcomes in the highly active antiretroviral therapy era. J Clin Oncol Off J Am Soc Clin Oncol. 2008;26(3):474–9. doi:10.1200/jco.2007.14.2810.CrossRef

14.

Abramowitz L, Mathieu N, Roudot-Thoraval F, Lemarchand N, Bauer P, Hennequin C, et al. Epidermoid anal cancer prognosis comparison among HIV+ and HIV- patients. Aliment Pharmacol Ther. 2009;30(4):414–21. doi:10.1111/j.1365-2036.2009.04026.x.CrossRefPubMed

15.

Seo Y, Kinsella MT, Reynolds HL, Chipman G, Remick SC, Kinsella TJ. Outcomes of chemoradiotherapy with 5-Fluorouracil and mitomycin C for anal cancer in immunocompetent versus immunodeficient patients. Int J Radiat Oncol Biol Phys. 2009;75(1):143–9. doi:10.1016/j.ijrobp.2008.10.046.CrossRefPubMed

16.

Grandhi J, Philip P, Washington T, Shields A, Vaishampayan U, Heilburn L, et al. A retrospective review of anal squamous cell carcinoma in HIV positive and HIV negative patients (abstract 4153). J Clin Oncol Off J Am Soc Clin Oncol. 2006;24(suppl):215s.

17.

Shiels MS, Copeland G, Goodman MT, Harrell J, Lynch CF, Pawlish K, et al. Cancer stage at diagnosis in patients infected with the human immunodeficiency virus and transplant recipients. Cancer. 2015;121(12):2063–71. doi:10.1002/cncr.29324.CrossRefPubMedPubMedCentral

18.

Silverberg MJ, Lau B, Justice AC, Engels E, Gill MJ, Goedert JJ, et al. Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America. Clin Infect Dis Off Publ Infect Dis Soc Am. 2012;54(7):1026–34. doi:10.1093/cid/cir1012.CrossRef

19.

Human papillomavirus-associated cancers - United States, 2004–2008. MMWR Morbidity and mortality weekly report 2012; 61:258–261

20.

Patel P, Hanson DL, Sullivan PS, Novak RM, Moorman AC, Tong TC, et al. Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992–2003. Ann Intern Med. 2008;148(10):728–36.CrossRefPubMed

21.

Piketty C, Selinger-Leneman H, Bouvier AM, Belot A, Mary-Krause M, Duvivier C, et al. Incidence of HIV-related anal cancer remains increased despite long-term combined antiretroviral treatment: results from the french hospital database on HIV. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30(35):4360–6. doi:10.1200/jco.2012.44.5486.CrossRef

22.

Kim R, Byer J, Fulp WJ, Mahipal A, Dinwoodie W, Shibata D. Carboplatin and paclitaxel treatment is effective in advanced anal cancer. Oncology. 2014;87(2):125–32. doi:10.1159/000361051.CrossRefPubMed

23.

Eng C, Chang GJ, You YN, Das P, Rodriguez-Bigas M, Xing Y, et al. The role of systemic chemotherapy and multidisciplinary management in improving the overall survival of patients with metastatic squamous cell carcinoma of the anal canal. Oncotarget. 2014;5(22):11133–42. doi:10.18632/oncotarget.2563.CrossRefPubMedPubMedCentral

24.

Sclafani F, Adams R, Eng C, Benson A, Glynne-Jones R, Sebag-Montefiore D, et al. InterAACT: an international multicenter open label randomized phase II advanced anal cancer trial comparing cisplatin (CDDP) plus 5-fluorouracil (5-FU) versus carboplatin (CBDCA) plus weekly paclitaxel (PTX) in patients with inoperable locally recurrent (ILR) or metastatic disease (abstract TPS792). J Clin Oncol Off J Am Soc Clin Oncol. 2015;33 suppl 3.

25.

Hainsworth JD, Burris 3rd HA, Meluch AA, Baker MN, Morrissey LH, Greco FA. Paclitaxel, carboplatin, and long-term continuous infusion of 5-fluorouracil in the treatment of advanced squamous and other selected carcinomas: results of a phase II trial. Cancer. 2001;92(3):642–9.CrossRefPubMed

26.

Jhawer M, Mani S, Lefkopoulou M, Hahn RG, Harris J, Catalano PJ, et al. Phase II study of mitomycin-C, adriamycin, cisplatin (MAP) and Bleomycin-CCNU in patients with advanced cancer of the anal canal: an eastern cooperative oncology group study E7282. Investig New Drugs. 2006;24(5):447–54. doi:10.1007/s10637-006-7667-x.CrossRef

27.

Wilking N, Petrelli N, Herrera L, Mittelman A. Phase II study of combination bleomycin, vincristine and high-dose methotrexate (BOM) with leucovorin rescue in advanced squamous cell carcinoma of the anal canal. Cancer Chemother Pharmacol. 1985;15(3):300–2.CrossRefPubMed

28.

National Comprehensive Cancer Network. Anal Carcinoma NCCN Guidelines (Version 2.2015). . 2015.

29.

Hoffman R, Welton ML, Klencke B, Weinberg V, Krieg R. The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer. Int J Radiat Oncol Biol Phys. 1999;44(1):127–31.CrossRefPubMed

30.

Salani R, Billingsley CC, Crafton SM. Cancer and pregnancy: an overview for obstetricians and gynecologists. Am J Obstet Gynecol. 2014;211(1):7–14. doi:10.1016/j.ajog.2013.12.002.CrossRefPubMed

31.

Voulgaris E, Pentheroudakis G, Pavlidis N. Cancer and pregnancy: a comprehensive review. Surg Oncol. 2011;20(4):e175–185. doi:10.1016/j.suronc.2011.06.002.CrossRefPubMed

32.

Watts DH. Management of human immunodeficiency virus infection in pregnancy. N Engl J Med. 2002;346(24):1879–91. doi:10.1056/NEJMra013338.CrossRefPubMed

33.

Warning JC, McCracken SA, Morris JM. A balancing act: mechanisms by which the fetus avoids rejection by the maternal immune system. Reproduction (Camb England). 2011;141(6):715–24. doi:10.1530/rep-10-0360.CrossRef

34.

Holtan SG, Creedon DJ, Haluska P, Markovic SN. Cancer and pregnancy: parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents. Mayo Clin Proc. 2009;84(11):985–1000. doi:10.1016/s0025-6196(11)60669-1.CrossRefPubMedPubMedCentral

Title: A Patient with HIV-Associated Metastatic Anal Squamous Cell Carcinoma Receiving Multimodality Therapy with Curative Intent: Case Report and Review of the Literature
Authors: Sunhee S. Kim
Grace E. Kim
Andrew H. Ko
Publication date: 01-03-2017
Publisher: Springer US
Published in: Journal of Gastrointestinal Cancer / Issue 1/2017
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-016-9814-8

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

A Patient with HIV-Associated Metastatic Anal Squamous Cell Carcinoma Receiving Multimodality Therapy with Curative Intent: Case Report and Review of the Literature

Excerpt

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 1/2017

A Case of Ruptured Adult Embryonal Sarcoma of the Liver with Excellent Outcome After Neoadjuvant Chemotherapy

A Rare Case of a Gastrointestinal Stromal Tumor (GIST) Presenting as a Perforated Meckel’s Diverticulum

Long-Term Outcomes and Prognostic Factors in Periampullary Carcinoma

Spontaneous Peritoneal Rupture of Gastric Stromal Tumor

Evaluation the Survival of Patients with Gastric Cancer Treated with Adjuvant or Palliative Chemotherapy

Capecitabine-Induced Severe Toxicity Secondary to DPD Deficiency and Successful Treatment with Low Dose 5-Fluorouracil

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page