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Immunologic Research
Published in: Immunologic Research 3/2017

01-06-2017 | Original Article

Neutralization of nerve growth factor (NGF) inhibits the Th2 response and protects against the respiratory syncytial virus (RSV) infection

Authors: Xiaorong Wu, Xiong Zhou, Yuxiang Hu, Chao Liu, Jun Wang

Published in: Immunologic Research | Issue 3/2017

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Abstract

Increasing evidence suggests that respiratory syncytial virus (RSV) infection during the early life is an important risk factor for the development of asthma. RSV infection is associated with neurogenic inflammation in the airways along with the increased expression of nerve growth factor (NGF). However, the role of NGF in RSV infection is not clear. In this study, we infected the rat with RSV and treated these animals with anti-NGF neutralization antibody. We found that anti-NGF treatment significantly alleviated the lung inflammation as evidenced by decreased inflammatory infiltration and decreased airway resistance. Importantly, anti-NGF treatment resulted in increased Th1, but decreased Th2 immune responses, and facilitated the viral control in the tissues and blood. Therefore, NGF inhibited Th2 but increased Th1 responses in RSV infection. Pharmacological intervention of NGF signaling during severe RSV infections could prevent or decrease further asthma symptoms.
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Metadata
Title
Neutralization of nerve growth factor (NGF) inhibits the Th2 response and protects against the respiratory syncytial virus (RSV) infection
Authors
Xiaorong Wu
Xiong Zhou
Yuxiang Hu
Chao Liu
Jun Wang
Publication date
01-06-2017
Publisher
Springer US
Published in
Immunologic Research / Issue 3/2017
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-017-8909-z

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