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01-06-2017 | Original Article

LPS-treated bone marrow-derived dendritic cells induce immune tolerance through modulating differentiation of CD4⁺ regulatory T cell subpopulations mediated by 3G11 and CD127

Authors: Fang Zhou, Guang-Xian Zhang, Abdolmohamad Rostami

Published in: Immunologic Research | Issue 3/2017

Abstract

Intravenous transfer of LPS-treated bone marrow-derived dendritic cells blocks development of autoimmunity induced by CD4⁺ T cells in vivo. However, cellular mechanisms of dendritic cell-mediated immune tolerance have not yet been fully elucidated. Here, we report that there are two new subpopulations of CD4⁺CD25⁺FoxP3⁺GITR⁺ regulatory T cells (CD127⁺3G11⁺ and CD127⁺3G11⁻ cells). LPS-treated dendritic cells facilitate development of CD4⁺CD127⁺3G11⁻ regulatory T cells but inhibit that of CD4⁺CD127⁺3G11⁺ regulatory T cells. LPS-induced tolerogenic dendritic cells may cause immune tolerance through modulating balance of different subsets of CD4⁺ regulatory T cells mediated by CD127 and 3G11. Our results imply a new potential cellular mechanism of dendritic cell-mediated immune tolerance.

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Title: LPS-treated bone marrow-derived dendritic cells induce immune tolerance through modulating differentiation of CD4+ regulatory T cell subpopulations mediated by 3G11 and CD127
Authors: Fang Zhou
Guang-Xian Zhang
Abdolmohamad Rostami
Publication date: 01-06-2017
Publisher: Springer US
Published in: Immunologic Research / Issue 3/2017
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-016-8881-z

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Springer Medicine

LPS-treated bone marrow-derived dendritic cells induce immune tolerance through modulating differentiation of CD4⁺ regulatory T cell subpopulations mediated by 3G11 and CD127

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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