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Forensic Science, Medicine and Pathology
Published in: Forensic Science, Medicine and Pathology 1/2022

01-03-2022 | Pancreatic Cancer | Letter to the Editor

Recognition and confirmation of Fox sign

Authors: Steven H. Yale, Halil Tekiner, Eileen S. Yale

Published in: Forensic Science, Medicine and Pathology | Issue 1/2022

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Excerpt

We read with interest the paper by Prangenberg et al. “Fox sign in a case of terminal stage pancreatic cancer and suggestions for diagnosis” [1]. We commend the authors for their novel approach using a pancreatic enzyme lipase immunoassay in order to confirm the relationship between necrotizing pancreatitis and cutaneous ecchymosis within the tissue at the right flank and below the right inguinal ligament [1]. Herein, we further expand upon the clinical findings and clarify the associated conditions and pathophysiologic process of this sign. …
Literature
1.
2.
Fox JA. A diagnostic sign of extraperitoneal haemorrhage. Br J Surg. 1966;53:193–5.CrossRef
3.
Epperla N, Mazza JJ, Yale SH. A review of clinical signs related to ecchymosis. WMJ. 2015;114:61–5.PubMed
4.
Lankisch PG, Weber-Dany B, Maisonneuve P, Lowenfels AB. Skin signs in acute pancreatitis: frequency and implications for prognosis. J Intern Med. 2009;265:299–301.CrossRef
Metadata
Title
Recognition and confirmation of Fox sign
Authors
Steven H. Yale
Halil Tekiner
Eileen S. Yale
Publication date
01-03-2022
Publisher
Springer US
Published in
Forensic Science, Medicine and Pathology / Issue 1/2022
Print ISSN: 1547-769X
Electronic ISSN: 1556-2891
DOI
https://doi.org/10.1007/s12024-021-00413-w

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