Skip to main content
Top
Published in: Forensic Science, Medicine and Pathology 3/2020

01-09-2020 | Sarcoidosis | Images in Forensics

Post-mortem CT with macroscopic and microscopic correlation in a case of sudden death due to systemic sarcoidosis

Authors: Jatin Bodwal, Marc Napoleone, Jayantha Herath

Published in: Forensic Science, Medicine and Pathology | Issue 3/2020

Login to get access

Abstract

We report a case of sudden death due to systemic sarcoidosis in a fifty-four year old male who was reportedly healthy. A computerized tomography (CT) scan was performed before the autopsy. It showed cardiomegaly with hilar and abdominal lymphadenopathy. The autopsy showed pale yellow plaque deposition on the heart surface which was infiltrating the myocardium. Histological examination of the heart, lungs, liver, and spleen showed extensive sarcoid granulomata which helped in establishing the cause of death.
Literature
1.
3.
go back to reference Criado E, Sánchez M, Ramírez J, Arguis P, de Caralt TM, Perea RJ, et al. Pulmonary sarcoidosis: typical and atypical manifestations at high resolution computed tomography with pathologic correlation. Radiographics. 2010;30:1567–86.CrossRefPubMed Criado E, Sánchez M, Ramírez J, Arguis P, de Caralt TM, Perea RJ, et al. Pulmonary sarcoidosis: typical and atypical manifestations at high resolution computed tomography with pathologic correlation. Radiographics. 2010;30:1567–86.CrossRefPubMed
4.
go back to reference Miller BH, Rosado-de-christenson ML, Mcadams HP, Fishback NF. Thoracic sarcoidosis: radiologic-pathologic correlation. Radiographics. 1995;15:421–37.CrossRefPubMed Miller BH, Rosado-de-christenson ML, Mcadams HP, Fishback NF. Thoracic sarcoidosis: radiologic-pathologic correlation. Radiographics. 1995;15:421–37.CrossRefPubMed
5.
go back to reference Iwai K, Tachibana T, Takemura T, Matsui Y, Kitalchi M, Kawabata Y. Pathological studies on sarcoidosis autopsy. I. Epidemiological features of 320 cases in Japan. Acta Pathol Jpn. 1993;43:372–6.PubMed Iwai K, Tachibana T, Takemura T, Matsui Y, Kitalchi M, Kawabata Y. Pathological studies on sarcoidosis autopsy. I. Epidemiological features of 320 cases in Japan. Acta Pathol Jpn. 1993;43:372–6.PubMed
7.
go back to reference Miller CR, Boor PJ, Campbell GA. A case of previously unsuspected cardiac sarcoidosis diagnosed at autopsy and 23-year review of one institution’s sarcoidosis deaths. Acad Forensic Pathol. 2019;9:97–106.CrossRef Miller CR, Boor PJ, Campbell GA. A case of previously unsuspected cardiac sarcoidosis diagnosed at autopsy and 23-year review of one institution’s sarcoidosis deaths. Acad Forensic Pathol. 2019;9:97–106.CrossRef
8.
go back to reference Hajšl M, Sedloň P, Černohous M, Vašáková M, Sokol M, Zavoral M. Cardiac sarcoidosis as a cause of sudden death. Cor et Vasa. 2013;55:78–81.CrossRef Hajšl M, Sedloň P, Černohous M, Vašáková M, Sokol M, Zavoral M. Cardiac sarcoidosis as a cause of sudden death. Cor et Vasa. 2013;55:78–81.CrossRef
9.
go back to reference Kron J, Ellenbogen KA. Cardiac sarcoidosis: contemporary review. J Cardiovasc Electrophysiol. 2015;26:104–9.CrossRefPubMed Kron J, Ellenbogen KA. Cardiac sarcoidosis: contemporary review. J Cardiovasc Electrophysiol. 2015;26:104–9.CrossRefPubMed
10.
go back to reference Tavora F, Cresswell N, Li L. Comparison of necropsy findings in patients with sarcoidosis dying suddenly from cardiac sarcoidosis versus dying suddenly from other causes. Am J Cardiol. 2009;104:571–7.CrossRefPubMed Tavora F, Cresswell N, Li L. Comparison of necropsy findings in patients with sarcoidosis dying suddenly from cardiac sarcoidosis versus dying suddenly from other causes. Am J Cardiol. 2009;104:571–7.CrossRefPubMed
11.
go back to reference Fowler MR, Mambo NC. A case of severe cardiac sarcoidosis with minimal pulmonary involvement: a case report with literature review. Acad Forensic Pathol. 2018;8:407–15.CrossRefPubMedPubMedCentral Fowler MR, Mambo NC. A case of severe cardiac sarcoidosis with minimal pulmonary involvement: a case report with literature review. Acad Forensic Pathol. 2018;8:407–15.CrossRefPubMedPubMedCentral
12.
go back to reference Ginelliová A, Farkaš D, Farkašová Iannaccone S, Vyhnálková V. Sudden unexpected death due to severe pulmonary and cardiac sarcoidosis. Forensic Sci Med Pathol. 2016;12:319–23.CrossRefPubMed Ginelliová A, Farkaš D, Farkašová Iannaccone S, Vyhnálková V. Sudden unexpected death due to severe pulmonary and cardiac sarcoidosis. Forensic Sci Med Pathol. 2016;12:319–23.CrossRefPubMed
14.
go back to reference Byard RW, Manton M, Tsokos M. Sarcoidosis and mechanisms of unexpected death. J Forensic Sci. 2008;53:460–4.CrossRefPubMed Byard RW, Manton M, Tsokos M. Sarcoidosis and mechanisms of unexpected death. J Forensic Sci. 2008;53:460–4.CrossRefPubMed
15.
go back to reference Birnie DH, Sauer WH, Bogun F, Cooper JM, Culver DA, Duvernoy CS, et al. HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis. Heart Rhythm. 2014;11:1305–23.CrossRefPubMed Birnie DH, Sauer WH, Bogun F, Cooper JM, Culver DA, Duvernoy CS, et al. HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis. Heart Rhythm. 2014;11:1305–23.CrossRefPubMed
Metadata
Title
Post-mortem CT with macroscopic and microscopic correlation in a case of sudden death due to systemic sarcoidosis
Authors
Jatin Bodwal
Marc Napoleone
Jayantha Herath
Publication date
01-09-2020
Publisher
Springer US
Published in
Forensic Science, Medicine and Pathology / Issue 3/2020
Print ISSN: 1547-769X
Electronic ISSN: 1556-2891
DOI
https://doi.org/10.1007/s12024-020-00259-8

Other articles of this Issue 3/2020

Forensic Science, Medicine and Pathology 3/2020 Go to the issue