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27-12-2022 | Acromegaly | Viewpoint

Looking at the spine in controlled Acromegaly

Authors: Maria Francesca Birtolo, Simone Antonini, Andrea G. Lania, Gherardo Mazziotti

Published in: Endocrine | Issue 2/2023

Abstract

Skeletal fragility with high risk of vertebral fractures (VFs) is an emerging complication of growth hormone (GH) hypersecretion. VFs often coexist with spine arthropathy and both clinical conditions negatively impact on quality of life of acromegalic subjects. Management of spine osteopathy and arthropathy in acromegaly could be challenging since both complications can persist or even progress after biochemical control of disease. This article analyzes the latest evidence about possible pathophysiological links between VFs and spine arthropathy in active and controlled acromegaly, as well as the diagnostic and therapeutic aspects concerning the holistic management of acromegalic osteo-arthropathy.

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Title: Looking at the spine in controlled Acromegaly
Authors: Maria Francesca Birtolo
Simone Antonini
Andrea G. Lania
Gherardo Mazziotti
Publication date: 27-12-2022
Publisher: Springer US
Keyword: Acromegaly
Published in: Endocrine / Issue 2/2023
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-022-03258-7

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