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20-10-2022 | Magnetic Resonance Imaging | Brief report

Association between pituitary height and growth response to recombinant human growth hormone in prepubertal children with growth hormone deficiency

Authors: Zhixin Zhang, Xiaomeng Zhang, Wenquan Niu, Yuan Yuan

Published in: Endocrine | Issue 2/2023

Excerpt

Growth hormone deficiency (GHD), an important cause of short stature in pediatrics, can lead to a series of adverse consequences impacting normal growth and life quality [1], although its prevalence is relatively low (about 1 in 4000 children worldwide) [2]. The occurrence of GHD is intimately linked with insufficient secretion of growth hormone (GH) from pituitary [3]. …

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J.H. Quitmann, A.C. Rohenkohl, U. Kammerer, C. Schofl, M. Bullinger, H.G. Dorr, Quality of life of young adults after a growth hormone therapy with childhood onset. Dtsch Med Wochenschr. 139(46), 2335–2338 (2014). https://doi.org/10.1055/s-0034-1387314CrossRef

G. Rodari, E. Profka, F. Giacchetti, I. Cavenaghi, M. Arosio, C. Giavoli, Influence of biochemical diagnosis of growth hormone deficiency on replacement therapy response and retesting results at adult height. Sci. Rep. 11(1), 14553 (2021). https://doi.org/10.1038/s41598-021-93963-6CrossRef

A. Chinoy, P.G. Murray, Diagnosis of growth hormone deficiency in the paediatric and transitional age. Best. Pr. Res Clin. Endocrinol. Metab. 30(6), 737–747 (2016). https://doi.org/10.1016/j.beem.2016.11.002CrossRef

R.A. Gubitosi-Klug, L. Cuttler, Idiopathic short stature. Endocrinol. Metab. Clin. North Am. 34(3), 565–580 (2005). https://doi.org/10.1016/j.ecl.2005.04.003CrossRef

J.M. Wit, P.E. Clayton, A.D. Rogol, M.O. Savage, P.H. Saenger, P. Cohen, Idiopathic short stature: definition, epidemiology, and diagnostic evaluation. Growth Horm. IGF Res 18(2), 89–110 (2008). https://doi.org/10.1016/j.ghir.2007.11.004CrossRef

V. Pampanini, S. Pedicelli, J. Gubinelli, G. Scire, M. Cappa, B. Boscherini, S. Cianfarani, Brain magnetic resonance imaging as first-line investigation for growth hormone deficiency diagnosis in early childhood. Horm. Res Paediatr. 84(5), 323–330 (2015). https://doi.org/10.1159/000439590CrossRef

M. Kessler, M. Tenner, M. Frey, R. Noto, Pituitary volume in children with growth hormone deficiency, idiopathic short stature and controls. J. Pediatr. Endocrinol. Metab. 29(10), 1195–1200 (2016). https://doi.org/10.1515/jpem-2015-0404CrossRef

N. Dumrongpisutikul, A. Chuajak, S. Lerdlum, Pituitary height at magnetic resonance imaging in pediatric isolated growth hormone deficiency. Pediatr. Radio. 48(5), 694–700 (2018). https://doi.org/10.1007/s00247-018-4070-7CrossRef

F. Naderi, S.R. Eslami, S.A. Mirak, M. Khak, J. Amiri, B. Beyrami, B. Shekarchi, M. Poureisa, Effect of growth hormone deficiency on brain MRI findings among children with growth restrictions. J. Pediatr. Endocrinol. Metab. 28(1-2), 117–123 (2015). https://doi.org/10.1515/jpem-2013-0294CrossRef

10.

M. Cong, S. Qiu, R. Li, H. Sun, L. Cong, Z. Hou, Development of a predictive model of growth hormone deficiency and idiopathic short stature in children. Exp. Ther. Med 21(5), 494 (2021). https://doi.org/10.3892/etm.2021.9925CrossRef

11.

J. Schmitt, P. Thornton, A.N. Shah, A. Rahman, E. Kubota, P. Rizzuto, A. Gupta, S. Orsdemir, P.B. Kaplowitz, Brain MRIs may be of low value in most children diagnosed with isolated growth hormone deficiency. J. Pediatr. Endocrinol. Metab. 34(3), 333–340 (2021). https://doi.org/10.1515/jpem-2020-0579CrossRef

12.

O. Kara, I. Esen, D. Tepe, N.B. Gulleroglu, M. Tayfun, Relevance of pituitary gland magnetic resonance imaging results with clinical and laboratory findings in growth hormone deficiency. Med Sci. Monit. 24, 9473–9478 (2018). https://doi.org/10.12659/MSM.911977CrossRef

13.

H. Li, C.Y. Ji, X.N. Zong, Y.Q. Zhang, Height and weight standardized growth charts for Chinese children and adolescents aged 0 to 18 years. Zhonghua Er Ke Za Zhi 47(7), 487–492 (2009)

14.

Growth Hormone Research, S.: Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society. J Clin Endocrinol Metab 85(11), 3990–3993 (2000). https://doi.org/10.1210/jcem.85.11.6984

15.

A. Christoforidis, M. Badouraki, G. Katzos, M. Athanassiou-Metaxa, Bone age estimation and prediction of final height in patients with beta-thalassaemia major: a comparison between the two most common methods. Pediatr. Radio. 37(12), 1241–1246 (2007). https://doi.org/10.1007/s00247-007-0656-1CrossRef

16.

H. Sharma, N. Purwar, A. Kumar, R. Sahlot, U. Garg, B. Sharma, S.K. Mathur, Pituitary hypoplasia is the best MRI predictor of the severity and type of growth hormone deficiency in children with congenital growth hormone deficiency. J. Pediatr. Endocrinol. Metab. 34(7), 851–858 (2021). https://doi.org/10.1515/jpem-2021-0049CrossRef

17.

J. Hwang, S.W. Jo, E.B. Kwon, S.A. Lee, S.K. Chang, Prevalence of brain MRI findings in children with nonacquired growth hormone deficiency: a systematic review and meta-analysis. Neuroradiology 63(7), 1121–1133 (2021). https://doi.org/10.1007/s00234-021-02665-3CrossRef

18.

D. Zenaty, C. Garel, C. Limoni, P. Czernichow, J. Leger, Presence of magnetic resonance imaging abnormalities of the hypothalamic-pituitary axis is a significant determinant of the first 3 years growth response to human growth hormone treatment in prepubertal children with nonacquired growth hormone deficiency. Clin. Endocrinol. (Oxf.) 58(5), 647–652 (2003)CrossRef

19.

R. Coutant, S. Rouleau, F. Despert, N. Magontier, D. Loisel, J.M. Limal, Growth and adult height in GH-treated children with nonacquired GH deficiency and idiopathic short stature: the influence of pituitary magnetic resonance imaging findings. J. Clin. Endocrinol. Metab. 86(10), 4649–4654 (2001). https://doi.org/10.1210/jcem.86.10.7962CrossRef

20.

O. Lennartsson, O. Nilsson, M. Lodefalk, Discordance between stimulated and spontaneous growth hormone levels in short children is dependent on cut-off level and partly explained by refractoriness. Front Endocrinol. (Lausanne) 11, 584906 (2020). https://doi.org/10.3389/fendo.2020.584906CrossRef

Title: Association between pituitary height and growth response to recombinant human growth hormone in prepubertal children with growth hormone deficiency
Authors: Zhixin Zhang
Xiaomeng Zhang
Wenquan Niu
Yuan Yuan
Publication date: 20-10-2022
Publisher: Springer US
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Endocrine / Issue 2/2023
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-022-03217-2

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