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13-05-2022 | Antibiotic | Original Article

Association of antibiotics exposure within the first 2 years after birth with subsequent childhood type 1 diabetes

Authors: Dahye Lee, Seulggie Choi, Jooyoung Chang, Young Jun Park, Jae Hyun Kim, Sang Min Park

Published in: Endocrine | Issue 1/2022

Abstract

Purpose

Antibiotics prescription in early life can cause dysbiosis, an imbalance of gut microbiota. We aimed to reveal the relationship between antibiotics exposure during the first 2 years after birth and type 1 diabetes risk in children under 8 years of age using a nationally representative data from South Korea.

Methods

The final study population consisted of 63,434 children from the National Health Insurance Service (NHIS) database from 2008 to 2015. The primary exposure of interest was antibiotics prescription in first 2 years after birth. The analysis was conducted with cumulative defined daily dose (cDDD; 0–29, 30–59, ≥ 60 cDDD), the number of antibiotics classes (0–3, 4, ≥5 classes), and age at first antibiotics prescription (0–119, 120–239, ≥ 240 days). Age, sex, household income, and overweight were considered as potential confounding covariates.

Results

Compared to those within the less than 30 cDDD, other groups that were prescribed more antibiotics did not have a significant difference in diabetes risk (aHR 0.86, 95% CI 0.37–2.02 in ≥ 60 cDDD). The number of antibiotics classes and age at first antibiotics prescriptions were also not associated with the risk of type 1 diabetes. The development of diabetes was not related to the cDDD, the number of antibiotics classes, and age at first antibiotics prescription according to subgroup analysis which was stratified by overweight.

Conclusions

Antibiotics exposure within the first 2 years of life was not associated with subsequent diabetes risk. Future studies using a larger number of long-term follow-up data are needed.

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Title: Association of antibiotics exposure within the first 2 years after birth with subsequent childhood type 1 diabetes
Authors: Dahye Lee
Seulggie Choi
Jooyoung Chang
Young Jun Park
Jae Hyun Kim
Sang Min Park
Publication date: 13-05-2022
Publisher: Springer US
Keywords: Antibiotic
Overweight
Type 1 Diabetes
Published in: Endocrine / Issue 1/2022
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-022-03042-7

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