Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Endocrine
Published in: Endocrine 1/2022

01-04-2022 | Thyroid Disease | Original Article

Thyroid autoimmunity and adverse pregnancy outcomes: a prospective cohort study

Authors: Fausta Beneventi, Irene De Maggio, Camilla Bellingeri, Chiara Cavagnoli, Carolina Spada, Anna Boschetti, Flavia Magri, Arsenio Spinillo

Published in: Endocrine | Issue 1/2022

Login to get access

Excerpt

Thyroid disease during pregnancy is considered a risk factor for maternal and neonatal complications. The prevalence of overt hypothyroidism in pregnancy ranges from 0.3 to 0.7% [1, 2], while subclinical hypothyroidism occurs in 2–10% [2]. Autoimmune thyroid disease (ATD) is characterized by the presence of anti-thyroid antibodies irrespective of thyroid function status and its prevalence in pregnancy ranges from 5% to 14% [3]. …
Appendix
Available only for authorised users
Literature
1.
E.K. Alexander, E.N. Pearce, G.A. Brent, R.S. Brown, H. Chen, C. Dosiou, W.A. Grobman, P. Laurberg, J.H. Lazarus, S.J. Mandel et al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of thyroid disease during pregnancy and the postpartum. Thyroid 27(Sep), 1212 (2017)
2.
T. Salek, I. Dhaifalah, D. Langova, J. Havalova, The prevalence of maternal hypothyroidism in first trimester screening from 11 to 14 weeks of gestation. Biomed. Pap. Med Fac. Univ. Palacky. Olomouc Czech Repub. 163(Sep), 265–268 (2019)PubMedCrossRef
3.
S. De Leo, E.N. Pearce, Autoimmune thyroid disease during pregnancy. Lancet Diabetes Endocrinol. 6(Jul), 575–586 (2018)PubMedCrossRef
4.
Thyroid Disease in Pregnancy, ACOG Practice Bulletin, Number 223. Obstet. Gynecol. 135(Jun), e261–e274 (2020)
5.
P.W. Rosario, M. Carvalho, M.R. Calsolari, TSH reference values in the first trimester of gestation and correlation between maternal TSH and obstetric and neonatal outcomes: a prospective Brazilian study. Arch. Endocrinol. Metab. 60(Aug), 314–8 (2016)PubMedCrossRef
6.
T.C. Plowden, E.F. Schisterman, L.A. Sjaarda, S.M. Zarek, N.J. Perkins, R. Silver, N. Galai, A.H. DeCherney, S.L. Mumford, Subclinical Hypothyroidism and Thyroid Autoimmunity Are Not Associated With Fecundity, Pregnancy Loss, or Live Birth. J. Clin. Endocrinol. Metab. 101(Jun), 2358–65 (2016)PubMedPubMedCentralCrossRef
7.
A. Stagnaro-Green, A. Dong, M.D. Stephenson, Universal screening for thyroid disease during pregnancy should be performed. Best. Pr. Res Clin. Endocrinol. Metab. 34(Jul), 101320 (2020)CrossRef
8.
A. Stagnaro-Green, X. Chen, J.D. Bogden, T.F. Davies, T.O. Scholl, The thyroid and pregnancy: a novel risk factor for very preterm delivery. Thyroid 15(Apr), 351–7 (2005)PubMedCrossRef
9.
T. Lepoutre, F. Debiève, D. Gruson, C. Daumerie, Reduction of miscarriages through universal screening and treatment of thyroid autoimmune diseases. Gynecol. Obstet. Invest 74, 265–73 (2012)PubMedCrossRef
10.
R. Negro, G. Formoso, T. Mangieri, A. Pezzarossa, D. Dazzi, H. Hassan, Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J. Clin. Endocrinol. Metab. 91(Jul), 2587–91 (2006)PubMedCrossRef
11.
R. Negro, A. Schwartz, A. Stagnaro-Green, Impact of levothyroxine in miscarriage and preterm delivery rates in first trimester thyroid antibody-positive women with TSH less than 2.5 mIU/L. J. Clin. Endocrinol. Metab. 101(Oct), 3685–3690 (2016)PubMedCrossRef
12.
S. Nazarpour, F. Ramezani Tehrani, M. Simbar, M. Tohidi, H. Alavi Majd, F. Azizi, Effects of levothyroxine treatment on pregnancy outcomes in pregnant women with autoimmune thyroid disease. Eur. J. Endocrinol. 176(Feb), 253–265 (2017)PubMedCrossRef
13.
M. Rotondi, L. Chiovato, F. Pacini, L. Bartalena, P. Vitti, Management of subclinical hypothyroidism in pregnancy: a comment from the italian society of endocrinology and the italian thyroid association to the 2017 American thyroid association guidelines-“the italian way”. Thyroid 28(May), 551–555 (2018)PubMedCrossRef
14.
A. Spinillo, F. Beneventi, V. Ramoni, R. Caporali, E. Locatelli, M. Simonetta, C. Cavagnoli, C. Alpini, G. Albonico, E. Prisco et al. Prevalence and significance of previously undiagnosed rheumatic diseases in pregnancy. Ann. Rheum. Dis. 71(Jun), 918–23 (2012)PubMedCrossRef
15.
A. Bhide, G. Acharya, C.M. Bilardo, C. Brezinka, D. Cafici, E. Hernandez-Andrade, K. Kalache, J. Kingdom, T. Kiserud, W. Lee et al. ISUOG practice guidelines: use of Doppler ultrasonography in obstetrics. Ultrasound Obstet. Gynecol. 41(Feb), 233–39 (2013)PubMed
16.
T. Frusca, M. Soregaroli, A. Valcamonico, F. Guandalini, L. Danti, Doppler velocimetry of the uterine arteries in nulliparous women. Early Hum. Dev. 48(Apr), 177–85 (1997)PubMedCrossRef
17.
L. Drukker, E. Staines-Urias, J. Villar, F.C. Barros, M. Carvalho, S. Munim, R. McGready, F. Nosten, J.A. Berkley, S.A. Norris et al. International gestational age-specific centiles for umbilical artery Doppler indices: a longitudinal prospective cohort study of the INTERGROWTH-21st Project. Am. J. Obstet. Gynecol. 222(Jun), 602.e1–602.e15 (2020)CrossRef
18.
S.J. Gordijn, I.M. Beune, B. Thilaganathan et al. Consensus definition of fetal growth restriction: a Delphi procedure. Ultrasound Obstet. Gynecol. 48, 333–339 (2016)PubMedCrossRef
19.
ACOG Practice Bulletin No, 202: Gestational Hypertension and Preeclampsia. Obstet. Gynecol. 133(Jan), 1 (2019)
20.
E. Bertino, E. Spada, L. Occhi, A. Coscia, F. Giuliani, L. Gagliardi, G. Gilli, G. Bona, C. Fabris, M. De Curtis et al. Neonatal anthropometric charts: the Italian neonatal study compared with other European studies. J. Pediatr. Gastroenterol. Nutr. 51(Sep), 353–61 (2010)PubMedCrossRef
21.
R.K. Dhillon-Smith, A. Tobias, P.P. Smith, L.J. Middleton, K.K. Sunner, K. Baker, S. Farrell-Carver, R. Bender-Atik, R. Agrawal, K. Bhatia et al. The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility. J. Clin. Endocrinol. Metab. 105(Aug), dgaa302 (2020)PubMed
22.
23.
M. Abbassi-Ghanavati, B.M. Casey, C.Y. Spong, D.D. McIntire, L.M. Halvorson, F.G. Cunningham, Pregnancy outcomes in women with thyroid peroxidase antibodies. Obstet. Gynecol. 116(Aug), 381–386 (2010)PubMedCrossRef
24.
C. Ticconi, E. Giuliani, M. Veglia, A. Pietropolli, E. Piccione, N. Di Simone, Thyroid autoimmunity and recurrent miscarriage. Am. J. Reprod. Immunol. 66(Dec), 452–9 (2011)PubMedCrossRef
25.
F. Beneventi, E. Locatelli, R. Caporali, C. Alpini, E. Lovati, V. Ramoni, M. Simonetta, C. Cavagnoli, C. Montecucco, A. Spinillo, Connective tissue diseases and autoimmune thyroid disorders in the first trimester of pregnancy. J. Reprod. Immunol. 114(Apr), 32–7 (2016)PubMedCrossRef
26.
M.G. Tektonidou, M. Anapliotou, P. Vlachoyiannopoulos, H.M. Moutsopoulos, Presence of systemic autoimmune disorders in patients with autoimmune thyroid diseases. Ann. Rheum. Dis. 63(Sep), 1159–61 (2004)PubMedPubMedCentralCrossRef
27.
T. Siriwardhane, K. Krishna, V. Ranganathan, V. Jayaraman, T. Wang, K. Bei, J.J. Rajasekaran, H. Krishnamurthy, Exploring Systemic Autoimmunity in Thyroid Disease Subjects. J. Immunol. Res 2018(Dec), 6895146 (2018)PubMedPubMedCentral
28.
R.K. Dhillon-Smith, A. Coomarasamy, TPO antibody positivity and adverse pregnancy outcomes. Best. Pr. Res Clin. Endocrinol. Metab. 34(Jul), 101433 (2020)CrossRef
29.
H. Liu, Z. Shan, C. Li, J. Mao, X. Xie, W. Wang, C. Fan, H. Wang, H. Zhang, C. Han et al. Maternal subclinical hypothyroidism, thyroid autoimmunity, and the risk of miscarriage: a prospective cohort study. Thyroid 24(Nov), 1642–9 (2014)PubMedPubMedCentralCrossRef
30.
E. van den Boogaard, R. Vissenberg, J.A. Land, M. van Wely, J.A. Ven der Post, M. Goddijn, P.H. Bisschop, Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review. Hum. Reprod. Update 22(Jun), 532–3 (2016)PubMedCrossRef
31.
T.I. Korevaar, E.A. Steegers, V.J. Pop, M.A. Broeren, L. Chaker, Y.B. de Rijke, V.W. Jaddoe, M. Medici, T.J. Visser, H. Tiemeier et al. Thyroid autoimmunity impairs the thyroidal response to human chorionic gonadotropin: two population-based prospective cohort studies. J. Clin. Endocrinol. Metab. 102(Jan), 69–77 (2017)PubMed
32.
S. Thangaratinam, A. Tan, E. Knox, M.D. Kilby, J. Franklyn, A. Coomarasamy, Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence. BMJ 342(May), d2616 (2011)PubMedPubMedCentralCrossRef
33.
X. He, P. Wang, Z. Wang, X. He, D. Xu, B. Wang, Thyroid antibodies and risk of preterm delivery: a meta-analysis of prospective cohort studies. Eur. J. Endocrinol. 167(Oct), 455–64 (2012)PubMedCrossRef
34.
Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth, T.I.M. Korevaar, A. Derakhshan, P.N. Taylor, M. Meima, L. Chen, S. Bliddal, D.M. Carty, M. Meems, B. Vaidya, B. Shields et al. Association of thyroid function test abnormalities and thyroid autoimmunity with preterm birth: a systematic review and meta-analysis. JAMA 322(Aug), 632–641 (2019)CrossRef
35.
G. Sitoris, F. Veltri, P. Kleynen, A. Cogan, J. Belhomme, S. Rozenberg, T. Pepersack, K. Poppe, The impact of thyroid disorders on clinical pregnancy outcomes in a real-world study setting. Thyroid 30(Jan), 106–115 (2020)PubMedCrossRef
36.
F. Saki, M.H. Dabbaghmanesh, S.Z. Ghaemi, S. Forouhari, G.R. Omrani, M. Bakhshayeshkaram, Thyroid autoimmunity in pregnancy and its influences on maternal and fetal outcome in Iran (a prospective study). Endocr. Res 40, 139–45 (2015)PubMedCrossRef
37.
D.L. Rolnik, D. Wright, L.C.Y. Poon, A. Syngelaki, N. O’Gorman, C. de Paco Matallana, R. Akolekar, S. Cicero, D. Janga, M. Singh et al. ASPRE trial: performance of screening for preterm pre-eclampsia. Ultrasound Obstet. Gynecol. 50(Dec), 807 (2017)
38.
A. Derakhshan, R.P. Peeters, P.N. Taylor, S. Bliddal, D.M. Carty, M. Meems, B. Vaidya, L. Chen, B.A. Knight, F. Ghafoor et al. Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol. 8(Jun), 501–510 (2020)PubMedPubMedCentralCrossRef
39.
Z. Tong, Z. Xiaowen, C. Baomin, L. Aihua, Z. Yingying, T. Weiping, S. Zhongyan, The effect of subclinical maternal thyroid dysfunction and autoimmunity on intrauterine growth restriction: a systematic review and meta-analysis. Med. (Baltim.) 95(May), e3677 (2016)CrossRef
40.
M. Medici, Y.B. de Rijke, R.P. Peeters, W. Visser, S.M. de Muinck Keizer-Schrama, V.V. Jaddoe, A. Hofman, H. Hooijkaas, E.A. Steegers, H. Tiemeier, J.J. Bongers-Schokking, T.J. Visser, Maternal early pregnancy and newborn thyroid hormone parameters: the Generation R study. J. Clin. Endocrinol. Metab. 97(Feb), 646–52 (2012)PubMedCrossRef
41.
T.I. Korevaar, S. Schalekamp-Timmermans, Y.B. de Rijke, W.E. Visser, W. Visser, S.M. de Muinck Keizer-Schrama, A. Hofman, H.A. Ross, H. Hooijkaas, H. Tiemeier, J.J. Bongers-Schokking, V.W. Jaddoe, T.J. Visser, E.A. Steegers, M. Medici, R.P. Peeters, Hypothyroxinemia and TPO-antibody positivity are risk factors for premature delivery: the generation R study. J. Clin. Endocrinol. Metab. 98(Nov), 4382–90 (2013)PubMedCrossRef
42.
K.J. Barber, J.A. Franklyn, C.J. McCabe, F.L. Khanim, J.N. Bulmer, G.S. Whitley, M.D. Kilby, The in vitro effects of triiodothyronine on epidermal growth factor-induced trophoblast function. J. Clin. Endocrinol. Metab. 90(Mar), 1655–61 (2005)PubMedCrossRef
43.
T.I.M. Korevaar, M. Medici, T.J. Visser, R.P. Peeters, Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nat. Rev. Endocrinol. 13(Oct), 610–622 (2017)PubMedCrossRef
44.
R. Rahnama, A.R. Mahmoudi, S. Kazemnejad, M. Salehi, A. Ghahiri, H. Soltanghoraee, S. Vafaei, A. Rezaei, A.H. Zarnani, Thyroid peroxidase in human endometrium and placenta: a potential target for anti-TPO antibodies. Clin. Exp. Med 21(Feb), 79–88 (2021)PubMedCrossRef
45.
R. Vissenberg, V.D. Manders, S. Mastenbroek, E. Fliers, G.B. Afink, C. Ris-Stalpers, M. Goddijn, P.H. Bisschop, Pathophysiological aspects of thyroid hormone disorders/thyroid peroxidase autoantibodies and reproduction. Hum. Reprod. Update 21(May-Jun), 378–87 (2015)PubMedCrossRef
46.
N.Y. Kim, H.J. Cho, H.Y. Kim, K.M. Yang, H.K. Ahn, S. Thornton, J.C. Park, K. Beaman, A. Gilman-Sachs, J. Kwak-Kim, Thyroid autoimmunity and its association with cellular and humoral immunity in women with reproductive failures. Am. J. Reprod. Immunol. 65(Jan), 78–87 (2011)PubMedCrossRef
47.
S. Bliddal, U. Feldt-Rasmussen, Å.K. Rasmussen, A.M. Kolte, L.M. Hilsted, O.B. Christiansen, C.H. Nielsen, H.S. Nielsen, Thyroid peroxidase antibodies and prospective live birth rate: a cohort study of women with recurrent pregnancy loss. Thyroid 29(Oct), 1465–1474 (2019)PubMedCrossRef
Metadata
Title
Thyroid autoimmunity and adverse pregnancy outcomes: a prospective cohort study
Authors
Fausta Beneventi
Irene De Maggio
Camilla Bellingeri
Chiara Cavagnoli
Carolina Spada
Anna Boschetti
Flavia Magri
Arsenio Spinillo
Publication date
01-04-2022
Publisher
Springer US
Published in
Endocrine / Issue 1/2022
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-021-02958-w

Other articles of this Issue 1/2022

Endocrine 1/2022 Go to the issue

Original Article

Molecular profiling of papillary thyroid carcinomas in healthcare workers exposed to low dose radiation at the workplace

Original Article

Teriparatide administration by the Omnipod pump: preliminary experience from two cases with refractory hypoparathyroidism

Original Article

Towards a pituitary apoplexy classification based on clinical presentation and patient journey

Original Article

Hypertension outcomes of adrenalectomy for unilateral primary aldosteronism

Research Letter

Menstrual cycle hormonal changes: estradiol-β-17 and progesterone interactions on exercise fat oxidation

Original Article

Clinical course and outcome of differentiated thyroid cancer patients with pregnancy after diagnosis of distant metastasis

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits