Published in:
01-02-2022 | Acute Kidney Injury | Research Letter
Diabetic ketoacidosis causes chronic elevation in renal C-C motif chemokine ligand 5
Authors:
Nicole Glaser, Luis Fernandez, Steven Chu, Martha E. O’Donnell
Published in:
Endocrine
|
Issue 2/2022
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Excerpt
Approximately 30–40% of adults with diabetes develop diabetic kidney disease, however, the pathophysiology and factors contributing to risk are incompletely understood [
1]. Diabetic ketoacidosis (DKA) is common in children with type 1 diabetes [
2,
3], and may also occur in type 2 diabetes [
4,
5]. Recent studies document that acute kidney injury (AKI) is frequent during DKA in children, occurring in 43–64% of episodes [
6‐
8]. Renal function returns to normal rapidly after DKA treatment, and episodes of AKI in children were not previously thought to have lasting consequences. However, a recent study by our group demonstrated that a single episode of AKI during DKA increases the risk of developing microalbuminuria by 60% and multiple episodes increase the risk by as much as fivefold [
9]. We hypothesized that DKA might trigger chronic renal inflammation resulting in elevated levels of inflammatory mediators in kidney tissue lysates. …
