Skip to main content
Top
Published in: Endocrine 3/2020

01-09-2020 | Coronavirus | Viewpoint

Mechanism of higher risk for COVID-19 in diabetes: a mask to lift

Authors: Chen Fang, Yun Huang, Heming Guo, Yihui Sun, Hui Li, Xuna Bian, Haixia Guan, Ji Hu

Published in: Endocrine | Issue 3/2020

Login to get access

Abstract

Purpose

This essay aims to propose suggestions on what we can learn from previous investigations to conduct further studies on the potential mechanisms underlying the effect of diabetes mellitus on COVID-19.

Methods

We reviewed some literature on diabetes and other types of coronavirus infection such as Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) and made some summaries and comparisons.

Results

Diabetes affect the occurrence and progression of COVID-19.

Conclusions

In-depth and comprehensive exploration of the mechanism of diabetes affecting COVID-19 should be carried out.
Literature
1.
go back to reference Q. Li, X. Guan, P. Wu et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 382(13), 1199–1207 (2020)CrossRef Q. Li, X. Guan, P. Wu et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 382(13), 1199–1207 (2020)CrossRef
2.
go back to reference H. Tu, S. Tu, S. Gao et al. The epidemiological and clinical features of COVID-19 and lessons from this global infectious public health event. J Infect. 18, S0163–S4453 (2020) H. Tu, S. Tu, S. Gao et al. The epidemiological and clinical features of COVID-19 and lessons from this global infectious public health event. J Infect. 18, S0163–S4453 (2020)
5.
go back to reference T. Chen, D. Wu, H. Chen et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 368, m1295 (2020) T. Chen, D. Wu, H. Chen et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 368, m1295 (2020)
6.
go back to reference F. Zhou, T. Yu, R. Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 395(10229), 1054–1062 (2020)CrossRef F. Zhou, T. Yu, R. Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 395(10229), 1054–1062 (2020)CrossRef
7.
go back to reference Q. Shi, X. Zhang, F. Jiang, Diabetic patients with COVID-19, characteristics and outcome—a two-centre, retrospective, case control study. SSRN Electronic Journal (2020) Q. Shi, X. Zhang, F. Jiang, Diabetic patients with COVID-19, characteristics and outcome—a two-centre, retrospective, case control study. SSRN Electronic Journal (2020)
8.
go back to reference Y.P. Zhang, The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China.chin. J Epidemiol 41(2), 145–151 (2020) Y.P. Zhang, The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China.chin. J Epidemiol 41(2), 145–151 (2020)
9.
go back to reference D. Wang, B. Hu, C. Hu et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 323(11), 1061–1069 (2020)CrossRef D. Wang, B. Hu, C. Hu et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 323(11), 1061–1069 (2020)CrossRef
10.
go back to reference X. Yang, Y. Yu, J. Xu et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet 8(5), 475–481 (2020) X. Yang, Y. Yu, J. Xu et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet 8(5), 475–481 (2020)
11.
go back to reference M. Letko, A. Marzi, V. Munster, Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol. 5(4), 562–569 (2020)CrossRef M. Letko, A. Marzi, V. Munster, Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol. 5(4), 562–569 (2020)CrossRef
12.
go back to reference J.-K. Yang, S.-S. Lin, X.-J. Ji, et al., Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 47(3), 193–199 (2010).CrossRef J.-K. Yang, S.-S. Lin, X.-J. Ji, et al., Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 47(3), 193–199 (2010).CrossRef
14.
go back to reference F.Y. Alqahtani, F.S. Aleanizy, R. Ali El Hadi Mohamed et al. Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study. Epidemiol Infect. 147, 1–5 (2018) F.Y. Alqahtani, F.S. Aleanizy, R. Ali El Hadi Mohamed et al. Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study. Epidemiol Infect. 147, 1–5 (2018)
15.
go back to reference C.M. Booth, L.M. Matukas, G.A. Tomlinson et al. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA. 289(21), 2801–2809 (2003)CrossRef C.M. Booth, L.M. Matukas, G.A. Tomlinson et al. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. JAMA. 289(21), 2801–2809 (2003)CrossRef
16.
go back to reference M. Cotten, T.T. Lam, S.J. Watson et al. Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus. Emerg Infect Dis 19(5), 736–742 (2013)CrossRef M. Cotten, T.T. Lam, S.J. Watson et al. Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus. Emerg Infect Dis 19(5), 736–742 (2013)CrossRef
17.
go back to reference M.A. Garbati, S.F. Fagbo, V.J. Fang et al. A comparative study of clinical presentation and risk factors for adverse outcome in patients hospitalised with acute respiratory disease due to MERS coronavirus or other causes. PLoS ONE 11(11), e0165978 (2016)CrossRef M.A. Garbati, S.F. Fagbo, V.J. Fang et al. A comparative study of clinical presentation and risk factors for adverse outcome in patients hospitalised with acute respiratory disease due to MERS coronavirus or other causes. PLoS ONE 11(11), e0165978 (2016)CrossRef
18.
go back to reference J.A. Al-Tawfiq, K. Hinedi, J. Ghandour et al. Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients. Clin Infect Dis 59(2), 160–165 (2014)CrossRef J.A. Al-Tawfiq, K. Hinedi, J. Ghandour et al. Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients. Clin Infect Dis 59(2), 160–165 (2014)CrossRef
19.
go back to reference F.Y. Alqahtani, F.S. Aleanizy, R. Ali El Hadi Mohamed et al. Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study. Epidemiol Infect 147, e35 (2019)CrossRef F.Y. Alqahtani, F.S. Aleanizy, R. Ali El Hadi Mohamed et al. Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study. Epidemiol Infect 147, e35 (2019)CrossRef
20.
go back to reference K.A. Kulcsar, C.M. Coleman, S.E. Beck et al. Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI Insight 4(20), e131774 (2019)CrossRef K.A. Kulcsar, C.M. Coleman, S.E. Beck et al. Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI Insight 4(20), e131774 (2019)CrossRef
21.
go back to reference J.W.M. Chan, C.K. Ng, Y.H. Chan et al. Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS). Thorax 58, 686–689 (2003)CrossRef J.W.M. Chan, C.K. Ng, Y.H. Chan et al. Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS). Thorax 58, 686–689 (2003)CrossRef
22.
go back to reference F. Wu, S. Zhao, B. Yu et al. A new coronavirus associated with human respiratory disease in China. Nature 579(7798), 265–269 (2020)CrossRef F. Wu, S. Zhao, B. Yu et al. A new coronavirus associated with human respiratory disease in China. Nature 579(7798), 265–269 (2020)CrossRef
23.
go back to reference K. Hodgson, J. Morris, T. Bridson et al. Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections. Immunology 144(2), 171–185 (2015)CrossRef K. Hodgson, J. Morris, T. Bridson et al. Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections. Immunology 144(2), 171–185 (2015)CrossRef
24.
go back to reference P. Kumar Nathella, S. Babu, Influence of diabetes mellitus on immunity to human tuberculosis. Immunology 152(1), 13–24 (2017)CrossRef P. Kumar Nathella, S. Babu, Influence of diabetes mellitus on immunity to human tuberculosis. Immunology 152(1), 13–24 (2017)CrossRef
25.
go back to reference D. Caldeira, J. Alarcão, A. Vaz-Carneiro et al. Risk of pneumonia associated with use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers: systematic review and meta-analysis. BMJ 345, e4260 (2012)CrossRef D. Caldeira, J. Alarcão, A. Vaz-Carneiro et al. Risk of pneumonia associated with use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers: systematic review and meta-analysis. BMJ 345, e4260 (2012)CrossRef
26.
go back to reference S.H. Hsia, P. Duran, M.L. Lee, M.B. Davidson, Randomized controlled trial comparing hydroxychloroquine with pioglitazone as third-line agents in type 2 diabetic patients failing metformin plus a Sulfonylurea: A pilot study. J Diabetes 12(1), 91–94 (2020)CrossRef S.H. Hsia, P. Duran, M.L. Lee, M.B. Davidson, Randomized controlled trial comparing hydroxychloroquine with pioglitazone as third-line agents in type 2 diabetic patients failing metformin plus a Sulfonylurea: A pilot study. J Diabetes 12(1), 91–94 (2020)CrossRef
27.
go back to reference F. Malik, S.F. Mehdi, H. Ali et al. Is metformin poised for a second career as an antimicrobial. Diabetes Metab Res Rev 34(4), e2975 (2018)CrossRef F. Malik, S.F. Mehdi, H. Ali et al. Is metformin poised for a second career as an antimicrobial. Diabetes Metab Res Rev 34(4), e2975 (2018)CrossRef
28.
go back to reference J. Tuñón, L. Badimón, M.L. Bochaton-Piallat et al. Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology. Cardiovasc Res 115(1), 10–19 (2019)CrossRef J. Tuñón, L. Badimón, M.L. Bochaton-Piallat et al. Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology. Cardiovasc Res 115(1), 10–19 (2019)CrossRef
29.
go back to reference H. Roca-Ho, M. Marta Riera, V. Palau et al. Characterization of ACE and ACE2 expression within different organs of the NOD mouse. Int J Mol Sci 18(563), 1–13. (2017) H. Roca-Ho, M. Marta Riera, V. Palau et al. Characterization of ACE and ACE2 expression within different organs of the NOD mouse. Int J Mol Sci 18(563), 1–13. (2017)
30.
go back to reference F.A. Shah, H. Mahmud, T. Gallego-Martin et al. Therapeutic effects of endogenous incretin hormones and exogenous incretin-based medications in sepsis. J Clin Endocrinol Metab 104(11), 5274–5284 (2019)CrossRef F.A. Shah, H. Mahmud, T. Gallego-Martin et al. Therapeutic effects of endogenous incretin hormones and exogenous incretin-based medications in sepsis. J Clin Endocrinol Metab 104(11), 5274–5284 (2019)CrossRef
Metadata
Title
Mechanism of higher risk for COVID-19 in diabetes: a mask to lift
Authors
Chen Fang
Yun Huang
Heming Guo
Yihui Sun
Hui Li
Xuna Bian
Haixia Guan
Ji Hu
Publication date
01-09-2020
Publisher
Springer US
Published in
Endocrine / Issue 3/2020
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-020-02423-0

Other articles of this Issue 3/2020

Endocrine 3/2020 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.