Association between age at menopause and fracture risk: a systematic review and meta-analysis

go back to reference D.M. Black, C.J. Rosen, Clinical practice. Postmenopausal osteoporosis. N. Engl. J. Med. 374(3), 254–262 (2016)CrossRef D.M. Black, C.J. Rosen, Clinical practice. Postmenopausal osteoporosis. N. Engl. J. Med. 374(3), 254–262 (2016)CrossRef

go back to reference C. Pike, H.G. Birnbaum, M. Schiller, H. Sharma, R. Burge, E.T. Edgell, Direct and indirect costs of non-vertebral fracture patients with osteoporosis in the US. Pharmacoeconomics 28(5), 395–409 (2010)CrossRef C. Pike, H.G. Birnbaum, M. Schiller, H. Sharma, R. Burge, E.T. Edgell, Direct and indirect costs of non-vertebral fracture patients with osteoporosis in the US. Pharmacoeconomics 28(5), 395–409 (2010)CrossRef

go back to reference P. Vestergaard, L. Rejnmark, L. Mosekilde, Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications. Osteoporos. Int. 18(12), 1583–1593 (2007)CrossRef P. Vestergaard, L. Rejnmark, L. Mosekilde, Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications. Osteoporos. Int. 18(12), 1583–1593 (2007)CrossRef

go back to reference S.R. Davis, I. Lambrinoudaki, M. Lumsden, G.D. Mishra, L. Pal, M. Rees, N. Santoro, T. Simoncini, Menopause. Nat. Rev. Dis. Prim. 1, 15004 (2015)CrossRef S.R. Davis, I. Lambrinoudaki, M. Lumsden, G.D. Mishra, L. Pal, M. Rees, N. Santoro, T. Simoncini, Menopause. Nat. Rev. Dis. Prim. 1, 15004 (2015)CrossRef

go back to reference J.S. Finkelstein, S.E. Brockwell, V. Mehta, G.A. Greendale, M.R. Sowers, B. Ettinger, J.C. Lo, J.M. Johnston, J.A. Cauley, M.E. Danielson, R.M. Neer, Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J. Clin. Endocrinol. Metab. 93(3), 861–868 (2008). https://doi.org/10.1210/jc.2007-1876. CrossRefPubMed J.S. Finkelstein, S.E. Brockwell, V. Mehta, G.A. Greendale, M.R. Sowers, B. Ettinger, J.C. Lo, J.M. Johnston, J.A. Cauley, M.E. Danielson, R.M. Neer, Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J. Clin. Endocrinol. Metab. 93(3), 861–868 (2008). https://​doi.​org/​10.​1210/​jc.​2007-1876.​ CrossRefPubMed

go back to reference S.S. Faubion, C.L. Kuhle, L.T. Shuster, W.A. Rocca, Long-term health consequences of premature or early menopause and considerations for management. Climacteric 18(4), 483–491 (2015)CrossRef S.S. Faubion, C.L. Kuhle, L.T. Shuster, W.A. Rocca, Long-term health consequences of premature or early menopause and considerations for management. Climacteric 18(4), 483–491 (2015)CrossRef

go back to reference L.T. Shuster, D.J. Rhodes, B.S. Gostout, B.R. Grossardt, W.A. Rocca, Premature menopause or early menopause: long-term health consequences. Maturitas 65(2), 161–166 (2010)CrossRef L.T. Shuster, D.J. Rhodes, B.S. Gostout, B.R. Grossardt, W.A. Rocca, Premature menopause or early menopause: long-term health consequences. Maturitas 65(2), 161–166 (2010)CrossRef

go back to reference R.G. Cumming, R.J. Klineberg, Breastfeeding and other reproductive factors and the risk of hip fractures in elderly women. Int. J. Epidemiol. 22(4), 684–691 (1993)CrossRef R.G. Cumming, R.J. Klineberg, Breastfeeding and other reproductive factors and the risk of hip fractures in elderly women. Int. J. Epidemiol. 22(4), 684–691 (1993)CrossRef

go back to reference F. Parazzini, A. Tavani, E. Ricci, C. La Vecchia, Menstrual and reproductive factors and hip fractures in post menopausal women. Maturitas 24(3), 191–196 (1996)CrossRef F. Parazzini, A. Tavani, E. Ricci, C. La Vecchia, Menstrual and reproductive factors and hip fractures in post menopausal women. Maturitas 24(3), 191–196 (1996)CrossRef

go back to reference A. Papaioannou, L. Joseph, G. Ioannidis, C. Berger, T. Anastassiades, J.P. Brown, D.A. Hanley, W. Hopman, R.G. Josse, S. Kirkland, T.M. Murray, W.P. Olszynski, L. Pickard, J.C. Prior, K. Siminoski, J.D. Adachi, Risk factors associated with incident clinical vertebral and nonvertebral fractures in postmenopausal women: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos. Int. 16(5), 568–578 (2005)CrossRef A. Papaioannou, L. Joseph, G. Ioannidis, C. Berger, T. Anastassiades, J.P. Brown, D.A. Hanley, W. Hopman, R.G. Josse, S. Kirkland, T.M. Murray, W.P. Olszynski, L. Pickard, J.C. Prior, K. Siminoski, J.D. Adachi, Risk factors associated with incident clinical vertebral and nonvertebral fractures in postmenopausal women: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos. Int. 16(5), 568–578 (2005)CrossRef

go back to reference M. Tuppurainen, H. Kroger, R. Honkanen, E. Puntila, J. Huopio, S. Saarikoski, E. Alhava, Risks of perimenopausal fractures—a prospective population-based study. Acta Obstet. Gynecol. Scand. 74(8), 624–628 (1995)CrossRef M. Tuppurainen, H. Kroger, R. Honkanen, E. Puntila, J. Huopio, S. Saarikoski, E. Alhava, Risks of perimenopausal fractures—a prospective population-based study. Acta Obstet. Gynecol. Scand. 74(8), 624–628 (1995)CrossRef

go back to reference A. Paganini-Hill, K.A. Atchison, J.A. Gornbein, A. Nattiv, S.K. Service, S.C. White, Menstrual and reproductive factors and fracture risk: the Leisure World Cohort Study. J. Womens. Health. 14(9), 808–819 (2005)CrossRef A. Paganini-Hill, K.A. Atchison, J.A. Gornbein, A. Nattiv, S.K. Service, S.C. White, Menstrual and reproductive factors and fracture risk: the Leisure World Cohort Study. J. Womens. Health. 14(9), 808–819 (2005)CrossRef

go back to reference D.F. Stroup, J.A. Berlin, S.C. Morton, I. Olkin, G.D. Williamson, D. Rennie, D. Moher, B.J. Becker, T.A. Sipe, S.B. Thacker, Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283(15), 2008–2012 (2000)CrossRef D.F. Stroup, J.A. Berlin, S.C. Morton, I. Olkin, G.D. Williamson, D. Rennie, D. Moher, B.J. Becker, T.A. Sipe, S.B. Thacker, Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283(15), 2008–2012 (2000)CrossRef

go back to reference G.A. Wells, B. Shea, D. O’Connell, J. Peterson, V. Welch, P. Tugwell, The Newcastle-Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analyses. (2009). http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp [cited 2009 Oct 19] G.A. Wells, B. Shea, D. O’Connell, J. Peterson, V. Welch, P. Tugwell, The Newcastle-Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analyses. (2009). http://​www.​ohri.​ca/​programs/​clinical_​epidemiology/​oxford.​asp [cited 2009 Oct 19]

go back to reference M. Varenna, L. Binelli, F. Zucchi, P. Beltrametti, M. Gallazzi, L. Sinigaglia, Is the metatarsal fracture in postmenopausal women an osteoporotic fracture? A cross-sectional study on 113 cases. Osteoporos. Int. 7(6), 558–563 (1997)CrossRef M. Varenna, L. Binelli, F. Zucchi, P. Beltrametti, M. Gallazzi, L. Sinigaglia, Is the metatarsal fracture in postmenopausal women an osteoporotic fracture? A cross-sectional study on 113 cases. Osteoporos. Int. 7(6), 558–563 (1997)CrossRef

go back to reference D. Huo, D.S. Lauderdale, L. Li, Influence of reproductive factors on hip fracture risk in Chinese women. Osteoporos. Int. 14(8), 694–700 (2003)CrossRef D. Huo, D.S. Lauderdale, L. Li, Influence of reproductive factors on hip fracture risk in Chinese women. Osteoporos. Int. 14(8), 694–700 (2003)CrossRef

go back to reference D.J. van Der Voort, P.H. van Der Weijer, R. Barentsen, Early menopause: increased fracture risk at older age. Osteoporos. Int. 14(6), 525–530 (2003)CrossRef D.J. van Der Voort, P.H. van Der Weijer, R. Barentsen, Early menopause: increased fracture risk at older age. Osteoporos. Int. 14(6), 525–530 (2003)CrossRef

go back to reference M. van der Klift, C.E. de Laet, E.V. McCloskey, O. Johnell, J.A. Kanis, A. Hofman, H.A. Pols, Risk factors for incident vertebral fractures in men and women: the Rotterdam Study. J. Bone Miner. Res. 19(7), 1172–1180 (2004)CrossRef M. van der Klift, C.E. de Laet, E.V. McCloskey, O. Johnell, J.A. Kanis, A. Hofman, H.A. Pols, Risk factors for incident vertebral fractures in men and women: the Rotterdam Study. J. Bone Miner. Res. 19(7), 1172–1180 (2004)CrossRef

go back to reference M.R. Jenkins, A.V. Denison, Smoking status as a predictor of hip fracture risk in postmenopausal women of northwest Texas. Prev. Chronic Dis. 5(1), A09 (2008)PubMed M.R. Jenkins, A.V. Denison, Smoking status as a predictor of hip fracture risk in postmenopausal women of northwest Texas. Prev. Chronic Dis. 5(1), A09 (2008)PubMed

go back to reference E. Banks, G.K. Reeves, V. Beral, A. Balkwill, B. Liu, A. Roddam, Million Women Study, C.: Hip fracture incidence in relation to age, menopausal status, and age at menopause: prospective analysis. PLoS. Med. 6(11), e1000181 (2009)CrossRef E. Banks, G.K. Reeves, V. Beral, A. Balkwill, B. Liu, A. Roddam, Million Women Study, C.: Hip fracture incidence in relation to age, menopausal status, and age at menopause: prospective analysis. PLoS. Med. 6(11), e1000181 (2009)CrossRef

go back to reference E. Lespessailles, F.E. Cotte, C. Roux, P. Fardellone, F. Mercier, A.F. Gaudin, Prevalence and features of osteoporosis in the French general population: the Instant study. Jt. Bone Spine 76(4), 394–400 (2009)CrossRef E. Lespessailles, F.E. Cotte, C. Roux, P. Fardellone, F. Mercier, A.F. Gaudin, Prevalence and features of osteoporosis in the French general population: the Instant study. Jt. Bone Spine 76(4), 394–400 (2009)CrossRef

go back to reference F.A. Tremollieres, J.M. Pouilles, N. Drewniak, J. Laparra, C.A. Ribot, P. Dargent-Molina, Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool. J. Bone Miner. Res. 25(5), 1002–1009 (2010)CrossRef F.A. Tremollieres, J.M. Pouilles, N. Drewniak, J. Laparra, C.A. Ribot, P. Dargent-Molina, Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool. J. Bone Miner. Res. 25(5), 1002–1009 (2010)CrossRef

go back to reference C.S. Shin, M.J. Kim, S.M. Shim, J.T. Kim, S.H. Yu, B.K. Koo, H.Y. Cho, H.J. Choi, S.W. Cho, S.W. Kim, S.Y. Kim, S.O. Yang, N.H. Cho, The prevalence and risk factors of vertebral fractures in Korea. J. Bone Miner. Metab. 30(2), 183–192 (2012)CrossRef C.S. Shin, M.J. Kim, S.M. Shim, J.T. Kim, S.H. Yu, B.K. Koo, H.Y. Cho, H.J. Choi, S.W. Cho, S.W. Kim, S.Y. Kim, S.O. Yang, N.H. Cho, The prevalence and risk factors of vertebral fractures in Korea. J. Bone Miner. Metab. 30(2), 183–192 (2012)CrossRef

go back to reference A.K. Pfister, C.A. Welch, M.K. Emmett, N.W. Sheets, Risk factors predicting fractures in early postmenopausal women. W. V. Med. J. 109(3), 14–15 (2013). 8-12 A.K. Pfister, C.A. Welch, M.K. Emmett, N.W. Sheets, Risk factors predicting fractures in early postmenopausal women. W. V. Med. J. 109(3), 14–15 (2013). 8-12

go back to reference S.D. Sullivan, A. Lehman, F. Thomas, K.C. Johnson, R. Jackson, J. Wactawski-Wende, M. Ko, Z. Chen, J.D. Curb, B.V. Howard, Effects of self-reported age at nonsurgical menopause on time to first fracture and bone mineral density in the Women’s Health Initiative Observational Study. Menopause 22(10), 1035–1044 (2015)CrossRef S.D. Sullivan, A. Lehman, F. Thomas, K.C. Johnson, R. Jackson, J. Wactawski-Wende, M. Ko, Z. Chen, J.D. Curb, B.V. Howard, Effects of self-reported age at nonsurgical menopause on time to first fracture and bone mineral density in the Women’s Health Initiative Observational Study. Menopause 22(10), 1035–1044 (2015)CrossRef

go back to reference I. Lambrinoudaki, M. Flokatoula, E. Armeni, P. Pliatsika, A. Augoulea, A. Antoniou, A. Alexandrou, M. Creatsa, C. Panoulis, S. Dendrinos, X. Papacharalambous, Vertebral fracture prevalence among Greek healthy middle-aged postmenopausal women: association with demographics, anthropometric parameters, and bone mineral density. Spine J. 15(1), 86–94 (2015)CrossRef I. Lambrinoudaki, M. Flokatoula, E. Armeni, P. Pliatsika, A. Augoulea, A. Antoniou, A. Alexandrou, M. Creatsa, C. Panoulis, S. Dendrinos, X. Papacharalambous, Vertebral fracture prevalence among Greek healthy middle-aged postmenopausal women: association with demographics, anthropometric parameters, and bone mineral density. Spine J. 15(1), 86–94 (2015)CrossRef

go back to reference S.R. Cummings, M.C. Nevitt, W.S. Browner, K. Stone, K.M. Fox, K.E. Ensrud, J. Cauley, D. Black, T.M. Vogt, Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N. Engl. J. Med. 332(12), 767–773 (1995)CrossRef S.R. Cummings, M.C. Nevitt, W.S. Browner, K. Stone, K.M. Fox, K.E. Ensrud, J. Cauley, D. Black, T.M. Vogt, Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N. Engl. J. Med. 332(12), 767–773 (1995)CrossRef

go back to reference B.L. Riggs, S. Khosla, L.J. Melton 3rd, : Sex steroids and the construction and conservation of the adult skeleton. Endocr. Rev. 23(3), 279–302 (2002)CrossRef B.L. Riggs, S. Khosla, L.J. Melton 3rd, : Sex steroids and the construction and conservation of the adult skeleton. Endocr. Rev. 23(3), 279–302 (2002)CrossRef

go back to reference J.E. Rossouw, G.L. Anderson, R.L. Prentice, A.Z. LaCroix, C. Kooperberg, M.L. Stefanick, R.D. Jackson, S.A. Beresford, B.V. Howard, K.C. Johnson, J.M. Kotchen, J. Ockene, Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women’s health initiative randomized controlled trial. JAMA 288(3), 321–333 (2002)CrossRef J.E. Rossouw, G.L. Anderson, R.L. Prentice, A.Z. LaCroix, C. Kooperberg, M.L. Stefanick, R.D. Jackson, S.A. Beresford, B.V. Howard, K.C. Johnson, J.M. Kotchen, J. Ockene, Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women’s health initiative randomized controlled trial. JAMA 288(3), 321–333 (2002)CrossRef

go back to reference G.L. Anderson, M. Limacher, A.R. Assaf, T. Bassford, S.A. Beresford, H. Black, D. Bonds, R. Brunner, R. Brzyski, B. Caan, R. Chlebowski, D. Curb, M. Gass, J. Hays, G. Heiss, S. Hendrix, B.V. Howard, J. Hsia, A. Hubbell, R. Jackson, K.C. Johnson, H. Judd, J.M. Kotchen, L. Kuller, A.Z. LaCroix, D. Lane, R.D. Langer, N. Lasser, C.E. Lewis, J. Manson, K. Margolis, J. Ockene, M.J. O’Sullivan, L. Phillips, R.L. Prentice, C. Ritenbaugh, J. Robbins, J.E. Rossouw, G. Sarto, M.L. Stefanick, L. Van Horn, J. Wactawski-Wende, R. Wallace, S. Wassertheil-Smoller, Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA 291(14), 1701–1712 (2004)CrossRef G.L. Anderson, M. Limacher, A.R. Assaf, T. Bassford, S.A. Beresford, H. Black, D. Bonds, R. Brunner, R. Brzyski, B. Caan, R. Chlebowski, D. Curb, M. Gass, J. Hays, G. Heiss, S. Hendrix, B.V. Howard, J. Hsia, A. Hubbell, R. Jackson, K.C. Johnson, H. Judd, J.M. Kotchen, L. Kuller, A.Z. LaCroix, D. Lane, R.D. Langer, N. Lasser, C.E. Lewis, J. Manson, K. Margolis, J. Ockene, M.J. O’Sullivan, L. Phillips, R.L. Prentice, C. Ritenbaugh, J. Robbins, J.E. Rossouw, G. Sarto, M.L. Stefanick, L. Van Horn, J. Wactawski-Wende, R. Wallace, S. Wassertheil-Smoller, Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA 291(14), 1701–1712 (2004)CrossRef

go back to reference H. Mizunuma, Y. Taketani, H. Ohta, H. Honjo, I. Gorai, A. Itabashi, M. Shiraki, Dose effects of oral estradiol on bone mineral density in Japanese women with osteoporosis. Climacteric 13(1), 72–83 (2010)CrossRef H. Mizunuma, Y. Taketani, H. Ohta, H. Honjo, I. Gorai, A. Itabashi, M. Shiraki, Dose effects of oral estradiol on bone mineral density in Japanese women with osteoporosis. Climacteric 13(1), 72–83 (2010)CrossRef

go back to reference F.A. Tremollieres, J.M. Pouilles, C. Ribot, Withdrawal of hormone replacement therapy is associated with significant vertebral bone loss in postmenopausal women. Osteoporos. Int. 12(5), 385–390 (2001)CrossRef F.A. Tremollieres, J.M. Pouilles, C. Ribot, Withdrawal of hormone replacement therapy is associated with significant vertebral bone loss in postmenopausal women. Osteoporos. Int. 12(5), 385–390 (2001)CrossRef

go back to reference G. Papadakis, D. Hans, E. Gonzalez-Rodriguez, P. Vollenweider, G. Waeber, P.M. Marques-Vidal, O. Lamy, The benefit of menopausal hormone therapy on bone density and microarchitecture persists after its withdrawal. J. Clin. Endocrinol. Metab. 101(12), 5004–5011 (2016)CrossRef G. Papadakis, D. Hans, E. Gonzalez-Rodriguez, P. Vollenweider, G. Waeber, P.M. Marques-Vidal, O. Lamy, The benefit of menopausal hormone therapy on bone density and microarchitecture persists after its withdrawal. J. Clin. Endocrinol. Metab. 101(12), 5004–5011 (2016)CrossRef

go back to reference N.B. Watts, J.A. Cauley, R.D. Jackson, A.Z. LaCroix, C.E. Lewis, J.E. Manson, J.M. Neuner, L.S. Phillips, M.L. Stefanick, J. Wactawski-Wende, C. Crandall, No increase in fractures after stopping hormone therapy: results from the women’s health initiative. J. Clin. Endocrinol. Metab. 102(1), 302–308 (2017)PubMed N.B. Watts, J.A. Cauley, R.D. Jackson, A.Z. LaCroix, C.E. Lewis, J.E. Manson, J.M. Neuner, L.S. Phillips, M.L. Stefanick, J. Wactawski-Wende, C. Crandall, No increase in fractures after stopping hormone therapy: results from the women’s health initiative. J. Clin. Endocrinol. Metab. 102(1), 302–308 (2017)PubMed

go back to reference E.B. Gold, S.L. Crawford, N.E. Avis, C.J. Crandall, K.A. Matthews, L.E. Waetjen, J.S. Lee, R. Thurston, M. Vuga, S.D. Harlow, Factors related to age at natural menopause: longitudinal analyses from SWAN. Am. J. Epidemiol. 178(1), 70–83 (2013)CrossRef E.B. Gold, S.L. Crawford, N.E. Avis, C.J. Crandall, K.A. Matthews, L.E. Waetjen, J.S. Lee, R. Thurston, M. Vuga, S.D. Harlow, Factors related to age at natural menopause: longitudinal analyses from SWAN. Am. J. Epidemiol. 178(1), 70–83 (2013)CrossRef

go back to reference U. Stepaniak, K. Szafraniec, R. Kubinova, S. Malyutina, A. Peasey, H. Pikhart, A. Pajak, M. Bobak, Age at natural menopause in three central and eastern European urban populations: the HAPIEE study. Maturitas 75(1), 87–93 (2013)CrossRef U. Stepaniak, K. Szafraniec, R. Kubinova, S. Malyutina, A. Peasey, H. Pikhart, A. Pajak, M. Bobak, Age at natural menopause in three central and eastern European urban populations: the HAPIEE study. Maturitas 75(1), 87–93 (2013)CrossRef

go back to reference V. Mpalaris, P. Anagnostis, D.G. Goulis, I. Iakovou, Complex association between body weight and fracture risk in postmenopausal women. Obes. Rev. 16(3), 225–233 (2015)CrossRef V. Mpalaris, P. Anagnostis, D.G. Goulis, I. Iakovou, Complex association between body weight and fracture risk in postmenopausal women. Obes. Rev. 16(3), 225–233 (2015)CrossRef

go back to reference M.C. Navarro, M. Sosa, P. Saavedra, P. Lainez, M. Marrero, M. Torres, C.D. Medina, Poverty is a risk factor for osteoporotic fractures. Osteoporos. Int. 20(3), 393–398 (2009)CrossRef M.C. Navarro, M. Sosa, P. Saavedra, P. Lainez, M. Marrero, M. Torres, C.D. Medina, Poverty is a risk factor for osteoporotic fractures. Osteoporos. Int. 20(3), 393–398 (2009)CrossRef

go back to reference J.S. Laven, Genetics of early and normal menopause. Semin. Reprod. Med. 33(6), 377–383 (2015)CrossRef J.S. Laven, Genetics of early and normal menopause. Semin. Reprod. Med. 33(6), 377–383 (2015)CrossRef

go back to reference L. Stolk, J.R. Perry, D.I. Chasman, C. He, M. Mangino, P. Sulem, M. Barbalic, L. Broer, E.M. Byrne, F. Ernst, T. Esko, N. Franceschini, D.F. Gudbjartsson, J.J. Hottenga, P. Kraft, P.F. McArdle, E. Porcu, S.Y. Shin, A.V. Smith, S. van Wingerden, G. Zhai, W.V. Zhuang, E. Albrecht, B.Z. Alizadeh, T. Aspelund, S. Bandinelli, L.B. Lauc, J.S. Beckmann, M. Boban, E. Boerwinkle, F.J. Broekmans, A. Burri, H. Campbell, S.J. Chanock, C. Chen, M.C. Cornelis, T. Corre, A.D. Coviello, P. d’Adamo, G. Davies, U. de Faire, E.J. de Geus, I.J. Deary, G.V. Dedoussis, P. Deloukas, S. Ebrahim, G. Eiriksdottir, V. Emilsson, J.G. Eriksson, B.C. Fauser, L. Ferreli, L. Ferrucci, K. Fischer, A.R. Folsom, M.E. Garcia, P. Gasparini, C. Gieger, N. Glazer, D.E. Grobbee, P. Hall, T. Haller, S.E. Hankinson, M. Hass, C. Hayward, A.C. Heath, A. Hofman, E. Ingelsson, A.C. Janssens, A.D. Johnson, D. Karasik, S.L. Kardia, J. Keyzer, D.P. Kiel, I. Kolcic, Z. Kutalik, J. Lahti, S. Lai, T. Laisk, J.S. Laven, D.A. Lawlor, J. Liu, L.M. Lopez, Y.V. Louwers, P.K. Magnusson, M. Marongiu, N.G. Martin, I.M. Klaric, C. Masciullo, B. McKnight, S.E. Medland, D. Melzer, V. Mooser, P. Navarro, A.B. Newman, D.R. Nyholt, N.C. Onland-Moret, A. Palotie, G. Pare, A.N. Parker, N.L. Pedersen, P.H. Peeters, G. Pistis, A.S. Plump, O. Polasek, V.J. Pop, B.M. Psaty, K. Raikkonen, E. Rehnberg, J.I. Rotter, I. Rudan, C. Sala, A. Salumets, A. Scuteri, A. Singleton, J.A. Smith, H. Snieder, N. Soranzo, S.N. Stacey, J.M. Starr, M.G. Stathopoulou, K. Stirrups, R.P. Stolk, U. Styrkarsdottir, Y.V. Sun, A. Tenesa, B. Thorand, D. Toniolo, L. Tryggvadottir, K. Tsui, S. Ulivi, R.M. van Dam, Y.T. van der Schouw, C.H. van Gils, P. van Nierop, J.M. Vink, P.M. Visscher, M. Voorhuis, G. Waeber, H. Wallaschofski, H.E. Wichmann, E. Widen, C.J. Wijnands-van Gent, G. Willemsen, J.F. Wilson, B.H. Wolffenbuttel, A.F. Wright, L.M. Yerges-Armstrong, T. Zemunik, L. Zgaga, M.C. Zillikens, M. Zygmunt, A.M. Arnold, D.I. Boomsma, J.E. Buring, L. Crisponi, E.W. Demerath, V. Gudnason, T.B. Harris, F.B. Hu, D.J. Hunter, L.J. Launer, A. Metspalu, G.W. Montgomery, B.A. Oostra, P.M. Ridker, S. Sanna, D. Schlessinger, T.D. Spector, K. Stefansson, E.A. Streeten, U. Thorsteinsdottir, M. Uda, A.G. Uitterlinden, C.M. van Duijn, H. Volzke, A. Murray, J.M. Murabito, J.A. Visser, K.L. Lunetta, Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat. Genet. 44(3), 260–268 (2012)CrossRef L. Stolk, J.R. Perry, D.I. Chasman, C. He, M. Mangino, P. Sulem, M. Barbalic, L. Broer, E.M. Byrne, F. Ernst, T. Esko, N. Franceschini, D.F. Gudbjartsson, J.J. Hottenga, P. Kraft, P.F. McArdle, E. Porcu, S.Y. Shin, A.V. Smith, S. van Wingerden, G. Zhai, W.V. Zhuang, E. Albrecht, B.Z. Alizadeh, T. Aspelund, S. Bandinelli, L.B. Lauc, J.S. Beckmann, M. Boban, E. Boerwinkle, F.J. Broekmans, A. Burri, H. Campbell, S.J. Chanock, C. Chen, M.C. Cornelis, T. Corre, A.D. Coviello, P. d’Adamo, G. Davies, U. de Faire, E.J. de Geus, I.J. Deary, G.V. Dedoussis, P. Deloukas, S. Ebrahim, G. Eiriksdottir, V. Emilsson, J.G. Eriksson, B.C. Fauser, L. Ferreli, L. Ferrucci, K. Fischer, A.R. Folsom, M.E. Garcia, P. Gasparini, C. Gieger, N. Glazer, D.E. Grobbee, P. Hall, T. Haller, S.E. Hankinson, M. Hass, C. Hayward, A.C. Heath, A. Hofman, E. Ingelsson, A.C. Janssens, A.D. Johnson, D. Karasik, S.L. Kardia, J. Keyzer, D.P. Kiel, I. Kolcic, Z. Kutalik, J. Lahti, S. Lai, T. Laisk, J.S. Laven, D.A. Lawlor, J. Liu, L.M. Lopez, Y.V. Louwers, P.K. Magnusson, M. Marongiu, N.G. Martin, I.M. Klaric, C. Masciullo, B. McKnight, S.E. Medland, D. Melzer, V. Mooser, P. Navarro, A.B. Newman, D.R. Nyholt, N.C. Onland-Moret, A. Palotie, G. Pare, A.N. Parker, N.L. Pedersen, P.H. Peeters, G. Pistis, A.S. Plump, O. Polasek, V.J. Pop, B.M. Psaty, K. Raikkonen, E. Rehnberg, J.I. Rotter, I. Rudan, C. Sala, A. Salumets, A. Scuteri, A. Singleton, J.A. Smith, H. Snieder, N. Soranzo, S.N. Stacey, J.M. Starr, M.G. Stathopoulou, K. Stirrups, R.P. Stolk, U. Styrkarsdottir, Y.V. Sun, A. Tenesa, B. Thorand, D. Toniolo, L. Tryggvadottir, K. Tsui, S. Ulivi, R.M. van Dam, Y.T. van der Schouw, C.H. van Gils, P. van Nierop, J.M. Vink, P.M. Visscher, M. Voorhuis, G. Waeber, H. Wallaschofski, H.E. Wichmann, E. Widen, C.J. Wijnands-van Gent, G. Willemsen, J.F. Wilson, B.H. Wolffenbuttel, A.F. Wright, L.M. Yerges-Armstrong, T. Zemunik, L. Zgaga, M.C. Zillikens, M. Zygmunt, A.M. Arnold, D.I. Boomsma, J.E. Buring, L. Crisponi, E.W. Demerath, V. Gudnason, T.B. Harris, F.B. Hu, D.J. Hunter, L.J. Launer, A. Metspalu, G.W. Montgomery, B.A. Oostra, P.M. Ridker, S. Sanna, D. Schlessinger, T.D. Spector, K. Stefansson, E.A. Streeten, U. Thorsteinsdottir, M. Uda, A.G. Uitterlinden, C.M. van Duijn, H. Volzke, A. Murray, J.M. Murabito, J.A. Visser, K.L. Lunetta, Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat. Genet. 44(3), 260–268 (2012)CrossRef

go back to reference M.G. Braem, M. Voorhuis, Y.T. van der Schouw, P.H. Peeters, L.J. Schouten, M.J. Eijkemans, F.J. Broekmans, N.C. Onland-Moret, Interactions between genetic variants in AMH and AMHR2 may modify age at natural menopause. PLoS. One. 8(3), e59819 (2013)CrossRef M.G. Braem, M. Voorhuis, Y.T. van der Schouw, P.H. Peeters, L.J. Schouten, M.J. Eijkemans, F.J. Broekmans, N.C. Onland-Moret, Interactions between genetic variants in AMH and AMHR2 may modify age at natural menopause. PLoS. One. 8(3), e59819 (2013)CrossRef

go back to reference A. La Marca, G. Sighinolfi, C. Argento, V. Grisendi, L. Casarini, A. Volpe, M. Simoni, Polymorphisms in gonadotropin and gonadotropin receptor genes as markers of ovarian reserve and response in in vitro fertilization. Fertil. Steril. 99(4), 970–978.e971 (2013)CrossRef A. La Marca, G. Sighinolfi, C. Argento, V. Grisendi, L. Casarini, A. Volpe, M. Simoni, Polymorphisms in gonadotropin and gonadotropin receptor genes as markers of ovarian reserve and response in in vitro fertilization. Fertil. Steril. 99(4), 970–978.e971 (2013)CrossRef

go back to reference U. Styrkarsdottir, B.V. Halldorsson, S. Gretarsdottir, D.F. Gudbjartsson, G.B. Walters, T. Ingvarsson, T. Jonsdottir, J. Saemundsdottir, J.R. Center, T.V. Nguyen, Y. Bagger, J.R. Gulcher, J.A. Eisman, C. Christiansen, G. Sigurdsson, A. Kong, U. Thorsteinsdottir, K. Stefansson, Multiple genetic loci for bone mineral density and fractures. N. Engl. J. Med. 358(22), 2355–2365 (2008)CrossRef U. Styrkarsdottir, B.V. Halldorsson, S. Gretarsdottir, D.F. Gudbjartsson, G.B. Walters, T. Ingvarsson, T. Jonsdottir, J. Saemundsdottir, J.R. Center, T.V. Nguyen, Y. Bagger, J.R. Gulcher, J.A. Eisman, C. Christiansen, G. Sigurdsson, A. Kong, U. Thorsteinsdottir, K. Stefansson, Multiple genetic loci for bone mineral density and fractures. N. Engl. J. Med. 358(22), 2355–2365 (2008)CrossRef

go back to reference G.R. Ji, M. Yao, C.Y. Sun, Z.H. Li, Z. Han, BsmI, TaqI, ApaI, and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: a meta-analysis. Bone 47(3), 681–686 (2010)CrossRef G.R. Ji, M. Yao, C.Y. Sun, Z.H. Li, Z. Han, BsmI, TaqI, ApaI, and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: a meta-analysis. Bone 47(3), 681–686 (2010)CrossRef

go back to reference A.E. Weel, A.G. Uitterlinden, I.C. Westendorp, H. Burger, S.C. Schuit, A. Hofman, T.J. Helmerhorst, J.P. van Leeuwen, H.A. Pols, Estrogen receptor polymorphism predicts the onset of natural and surgical menopause. J. Clin. Endocrinol. Metab. 84(9), 3146–3150 (1999)PubMed A.E. Weel, A.G. Uitterlinden, I.C. Westendorp, H. Burger, S.C. Schuit, A. Hofman, T.J. Helmerhorst, J.P. van Leeuwen, H.A. Pols, Estrogen receptor polymorphism predicts the onset of natural and surgical menopause. J. Clin. Endocrinol. Metab. 84(9), 3146–3150 (1999)PubMed

go back to reference V. Dvornyk, J.R. Long, P.Y. Liu, H. Shen, R.R. Recker, H.W. Deng, Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females. Gynecol. Endocrinol. 22(10), 552–556 (2006)CrossRef V. Dvornyk, J.R. Long, P.Y. Liu, H. Shen, R.R. Recker, H.W. Deng, Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females. Gynecol. Endocrinol. 22(10), 552–556 (2006)CrossRef

go back to reference D.M. Black, J.A. Cauley, R. Wagman, K. Ensrud, H.A. Fink, T.A. Hillier, L.Y. Lui, S.R. Cummings, J.T. Schousboe, N. Napoli, The ability of a single BMD and fracture history assessment to predict fracture over 25 years in postmenopausal women: the study of osteoporotic fractures. J. Bone Miner. Res. 33(3), 389–395 (2018)CrossRef D.M. Black, J.A. Cauley, R. Wagman, K. Ensrud, H.A. Fink, T.A. Hillier, L.Y. Lui, S.R. Cummings, J.T. Schousboe, N. Napoli, The ability of a single BMD and fracture history assessment to predict fracture over 25 years in postmenopausal women: the study of osteoporotic fractures. J. Bone Miner. Res. 33(3), 389–395 (2018)CrossRef