Published in:
01-02-2019 | Letter to the Editor
Continuous subcutaneous hydrocortisone infusion in a woman with secondary adrenal insufficiency
Authors:
Francesca Cardini, Elisabetta Torlone, Vittorio Bini, Alberto Falorni
Published in:
Endocrine
|
Issue 2/2019
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Excerpt
Adrenal insufficiency requires long-term, often life-long, administration of 15–25 mg/day hydrocortisone in two to three daily doses, though personalized adjustments may be needed [
1]. Disruption of the circadian cortisol rhythm is associated with poor quality of life, sleep disturbances, asthenia, immune disturbances, and impairment of glucose/lipid metabolisms. Programmable pumps may be used for continuous subcutaneous hydrocortisone infusion (CSHI) with modulated rates that mimic the circadian rhythm of serum cortisol concentrations [
2]. We report the use of CSHI in a woman with secondary adrenal insufficiency (SAI) and multiple allergic reactions, including to excipients of the standard oral hydrocortisone tablet. …
